Metrogel Vaginal

Metrogel-Vaginal Side Effects

Reviewed by Kristianne Hannemann, PharmD, Daisy Chau, PharmD

Last reviewed on March 16, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Vandazole:

Vaginal fungal and yeast infection (12%)
Headache (7%)
Itching (6%)
Stomach pain (5%)

Generic metronidazole vaginal gel:

Vaginal discharge (12%)
Vaginal yeast infection (10%)
Vaginal irritation (9%)
Stomach discomfort (7%)
Headache (5%)

Less Common Side Effects

Vandazole:

Nausea
Period cramps
Sore throat
Rash
Infection
Diarrhea
Breast pain
Spotting between periods

Generic metronidazole vaginal gel:

Nausea
Vomiting
Unusual taste
Dizziness
Cramping
Reduced appetite

When do Metrogel-Vaginal possible side effects begin and end?

Time passed since treatment started:

HHOURS

DDAYS

WWEEKS

MMONTHS

Headache

Nausea

Vaginal itching

Vaginal yeast infection

Source: DailyMed

The following Metrogel-Vaginal side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Itching in the vagina

pain during sexual intercourse

thick, white vaginal discharge with no odor or with a mild odor

Less common

Burning on urination or need to urinate more often

burning or irritation of the penis of the sexual partner

feeling of vaginal pressure

itching, pain, stinging, or redness of the genital area

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Cramps

diarrhea

dizziness or lightheadedness

dryness of the mouth

feeling of a furry tongue

headache

heavy bleeding

loss of appetite

metallic taste or other change in taste sensation

mild skin dryness and burning

nausea