Atopica for Cats: A Medication to Treat Skin Allergies

Cats get allergies just like people do. And they may have irritating symptoms, such as itchy skin and inflammation. Atopica (cyclosporine, Cyclavance, Neoral), an allergy medication that suppresses the immune system, can help.

Here’s a closer look at Atopica for cats, including dosage, side effects, and serious risks. 

Atopica for cats at a glance

What is Atopica for cats, and how does it work?

Cyclosporine or Atopica is a medication that suppresses the immune system. It does so by blocking: 

• The activation of certain inflammatory cells

• The spread of certain inflammatory cells

• The chemical signals that cause inflammation

These actions work together to reduce itching and inflammation in cats with allergies such as atopic dermatitis. 

What is Atopica used for in cats?

Atopica is FDA approved to manage allergies in cats by controlling itching and inflammation. Atopica treats allergic conditions, including: 

• Atopic dermatitis

• Miliary dermatitis

• Eosinophilic granuloma complex

Veterinarians also prescribe Atopica off-label to treat some autoimmune diseases, such as: 

• Pemphigus foliaceus 

• Stomatitis (dental disease)

How is the dosage of Atopica for cats, and how is it given?

Your veterinarian will calculate your cat’s Atopica dosage based on its body weight and medical condition. Some conditions only need low doses of Atopica, while others need high doses. 

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Atopica is given once or twice daily. Follow your veterinarian’s directions.

Atopica is available as a capsule or as an oral suspension (liquid). You and your veterinarian will decide which is best for your cat. 

You can give Atopica with food or on an empty stomach, depending on which is easier for your cat.  

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What are the common side effects of Atopica in cats?

Common side effects of Atopica in cats include: 

• Decreased appetite

• Nausea

• Vomiting

• Diarrhea

• Weight loss

• Lethargy

• Behavior changes

If you notice any of these side effects, contact your veterinarian. If your cat’s side effects can’t be managed, your veterinarian may recommend a different medication.

What are the most serious risks of Atopica for cats?

Atopica can cause serious side effects, but it’s rare. Regular screening and monitoring can reduce serious risks.

In a study of 205 cats receiving Atopica, two cats developed hepatic lipidosis. This is a serious liver disease caused by not eating. If your cat is taking Atopica, monitor their appetite and body weight. Your veterinarian will likely recommend regular checkups. If your cat stops eating, contact your veterinarian immediately. Early intervention can help prevent hepatic lipidosis. 

Atopica suppresses the immune system, and this can increase a cat’s risk of infections. Veterinarians typically avoid prescribing Atopica to cats with a weakened immune system. This includes cats infected with: 

• Feline leukemia virus 

• Feline immunodeficiency virus 

Veterinarians also avoid prescribing Atopica to cats with other underlying infections. That’s because these infections could worsen if they take Atopica. 

Does Atopica interact with any other cat medications?

Yes. Common medications that may interact with Atopica include: 

• Antacids, including cimetidine, famotidine, and omeprazole

• Antibiotics, including ciprofloxacin, enrofloxacin, metronidazole, and trimethoprim

• Antifungal medications, including griseofulvin and ketoconazole

• Heart medications, including amiodarone and digoxin

• Immunosuppressive medications, including azathioprine and cyclophosphamide

• Metoclopramide (an antinausea medication)

• Phenobarbital (an antiseizure medication)

This is not a complete list of potential interactions. Talk to your veterinarian before combining other medications with Atopica. Tell them if your cat is taking:

• Prescription medications

• Over-the-counter medications

• Supplements 

What should you do if your cat misses a dose of Atopica?

If you forget to give your cat a dose of Atopica, give the missed dose as soon as possible. Then, resume your cat’s regular dosing schedule. 

If it’s almost time for your cat’s next dose, skip the missed dose and give your cat’s next dose as scheduled. 

Do not give a double dose of Atopica. This can increase the risk of serious side effects. 

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Written by:

Catherine Barnette, DVM

Catherine Barnette, DVM, is a small animal veterinarian with 14 years of experience. She also served on her county's board of health for several years and taught biology laboratories for college students.

Edited by:

Renée Fabian, MA

Renée Fabian is the senior pet health editor at GoodRx. She’s worked for nearly 10 years as a journalist and editor across a wide range of health and well-being topics.

Reviewed by:

Ghanasyam Bey, DVM

Ghanasyam Bey, DVM, is from Cleveland, Ohio, and attended Princeton University for undergraduate studies. After a year of biology research at Duke University, he attended Ohio State College of Veterinary Medicine.

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