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Cyclosporine Modified Coupon - Cyclosporine Modified 100mg capsule

cyclosporine modified

Generic Gengraf
Used for Organ Transplant, Plaque Psoriasis, Rheumatoid Arthritis

Cyclosporine modified is an immunosuppressant. The generic capsule and oral solution help treat certain health problems caused by an overactive immune system in dogs and cats. These generic versions are FDA approved for people, but vets often prescribe it off-label for pets. You usually give your pet this medication once or twice a day. Common side effects for pets are stomach problems like diarrhea, vomiting, and a low appetite.

Reviewed by:
reviewerElizabeth Carman, PharmD, FSVHP
reviewerCydnee Ng, PharmD
Last reviewed on May 20, 2025
Paws

For pets

Cyclosporine modified can be prescribed or used off-label by a licensed veterinarian for pets. Medications prescribed for pets aren't intended for human use.

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What is Cyclosporine modified for pets?

What is Cyclosporine modified for pets used for?

How Cyclosporine modified for pets works

Cyclosporine modified is a type of immunosuppressant. More specifically, it’s a calcineurin inhibitor. It blocks a protein in the immune system called calcineurin. This protein plays a role in causing inflammation when the immune system is too active.

By blocking calcineurin, cyclosporine modified helps calm your pet’s immune system. This helps lower inflammation in their body.

Drug facts

Common BrandsGengraf
Drug ClassImmunosuppressant
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Side effects of Cyclosporine modified for pets

The following side effects might get better over time as your pet gets used to the medication. Let your veterinarian know immediately if your pet continues to experience these symptoms or if they worsen over time.

Common Side Effects

  • Vomiting
  • Diarrhea
  • Low appetite

Less Common Side Effects

Dogs:

Cats:

  • Low energy
  • Overgrowth of the gums
  • Weight loss
  • Drooling
  • More hair growth
  • Behavior changes (e.g., hiding, being overactive, being aggressive)

Cyclosporine modified serious side effects

Contact your veterinarian immediately if your pet experiences any of the following.

  • Infection: fever, low energy, poor appetite, pain, cough, trouble breathing, sneezing, eye discharge, having a hard time urinating
  • Possible cancer: swollen lymph nodes, low energy, fever, low appetite
  • Liver problems: weakness, tiredness, weight loss, yellow eyes or skin
  • Kidney problems: needing to relieve themselves more or less often, thirsty, low appetite

The following Cyclosporine modified side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal or stomach pain or tenderness

back pain

black, tarry stools

blurred vision

chest pain

chills

clay colored stools

cloudy urine

cough

dark urine

decrease in urine output or decrease in urine-concentrating ability

decreased appetite

dizziness

drowsiness

fever

headache

headache, severe and throbbing

itching

loss of appetite

muscle spasms (tetany) or twitching

nausea and vomiting

nervousness

painful or difficult urination

pounding in the ears

shakiness in the legs, arms, hands, or feet

shortness of breath

skin rash

slow or fast heartbeat

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swelling of the feet or lower legs

swollen glands

trembling or shaking of the hands or feet

unusual bleeding or bruising

unusual tiredness or weakness

yellow eyes or skin

Less common

Bleeding gums

blood in the urine

blood in the vomit

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

convulsions

difficulty swallowing

hives

pale skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

severe or continuing stomach pain

tightness in the chest

troubled breathing with exertion

Rare

Bloating

chest discomfort

constipation

darkened urine

hoarseness

indigestion

lower back or side pain

night sweats

pain or discomfort in the arms, jaw, back, or neck

pains in the stomach, side, or abdomen, possibly radiating to the back

sweating

vomiting of blood or material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal or stomach discomfort

bleeding, tender, or enlarged gums

blemishes on the skin

increased hair growth, especially on the face

pain or tenderness around the eyes and cheekbones

pimples

stuffy or runny nose

Less common

Brittle fingernails

burning feeling in the chest or stomach

burning, dry, or itching eyes

continuing ringing or buzzing or other unexplained noise in the ears

cramps

discharge or excessive tearing

feeling of warmth

hearing loss

redness of the face, neck, arms, and occasionally, upper chest

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

swelling of the breasts or breast soreness in both females and males

weight loss

Rare

Blurred or loss of vision

discouragement

disturbed color perception

double vision

fear

feeling sad or empty

halos around lights

irritability

joint pain

loss of interest or pleasure

night blindness

overbright appearance of lights

tiredness

trouble concentrating

trouble sleeping

tunnel vision

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

weakness

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pros and cons of Cyclosporine modified for pets

Pros

Cons

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Pharmacist tips for Cyclosporine modified for pets

pharmacist
  • Make sure your pet is getting cyclosporine modified, not the unmodified version of cyclosporine (Sandimmune). These two versions are not the same. Vets don’t use unmodified cyclosporine (Sandimmune) for dogs or cats because pets don’t absorb it well. Ask your vet or pharmacist if you have any questions.
  • For dogs: Give cyclosporine modified without food, at least 1 hour before or 2 hours after a meal. This medication works best for dogs on an empty stomach. But you can give it with a small amount of food or a small treat to see if it helps with any stomach upset from the medication.
  • For cats: It doesn’t usually matter if you give cyclosporine modified with or without food for cats. Try to give it around the same time and in the same way each day.
  • If you’re pregnant, be careful and wear gloves when handling cyclosporine modified because it might harm an unborn baby. Even if you aren’t pregnant, try not to touch the medication. But if you do get it on yourself, wash the area well right away.
  • It’s common for pets to have diarrhea or vomit when starting cyclosporine modified. These side effects often get better with time. Make sure your pet drinks enough water to avoid dehydration. Talk to your vet before trying anything else to help because it might affect how the medication works. Your vet can help decide what’s best for your pet’s stomach problems.
  • Before your pet gets any vaccines, tell the vet staff that your pet is taking cyclosporine modified. Some vaccines, especially live vaccines, might not work with this medication. Ask your vet how well each vaccine might work for your pet.
  • Sometimes, vets prescribe an antifungal called ketoconazole with cyclosporine modified for your pet. Ketoconazole helps raise the amount of cyclosporine modified in your pet’s blood. This helps lower the dose of cyclosporine modified that your pet might need to take. Follow your vet’s directions if they use this treatment plan.
  • Talk to your vet before giving your pet any new medications to make sure it’s safe. Cyclosporine modified can interact with many other medications. Some examples include amlodipine, fluconazole, enrofloxacin, and phenobarbital.
  • If you have a small or young pet, ask your vet if cyclosporine modified is right for your pet. We don’t know if this medication is safe or works well for pets under 6 months of age, dogs that weigh less than 4 lbs, or cats that weigh less than 3 lbs. Your vet can discuss the risks and benefits of treatment for your pet with you.
  • Talk to a vet if your pet is pregnant or nursing. Animal studies show that cyclosporine modified can cause harm in baby rats. But it’s not clear for kittens or puppies. The vet can help you understand the risks and benefits.

Tips for the liquid form of cyclosporine modified:

  • Keep the cyclosporine modified liquid at room temperature (68ºF to 77ºF). Don’t put it in the refrigerator. If it gets too cold, the liquid can turn thick or clumpy. But it’ll go back to normal when you let it sit so it warms back up. Don’t use anything else to warm it up.
  • Follow your vet’s advice about how to give your pet the liquid medication. Don’t use household spoons to measure the dose since spoon sizes are different. Use a medication syringe or cup to measure the dose.
  • Discard the cyclosporine modified liquid 2 months after you open the bottle, even if there’s still some medication left.
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Common questions about Cyclosporine modified for pets

How long your dog takes cyclosporine modified depends on the health condition they have. These conditions usually need long-term treatment. This means that many dogs will probably need to take cyclosporine modified for a long time, possibly for life. But your vet might change your dog’s treatment plan if the medication isn’t working as well as hoped or if it causes side effects. Ask your vet if you have questions about how long your dog should take cyclosporine modified.

You can touch cyclosporine modified capsules when giving them to your dog. But try not to get the medication inside the capsules or the liquid form of the medication on your skin. Wash your hands right after handling the medication and before touching anything else. Rinse any areas of skin that the medication got onto by accident. If you’re pregnant, wear gloves when giving this medication to your dog since it could harm your baby. Ask your vet or pharmacist if you have questions.

Yes. Some dogs might need to take prednisone and cyclosporine modified together to treat their immune condition. A study found that the combination with a steroid helped dogs with skin allergies more than cyclosporine modified alone. Your dog might have side effects from each medication. For example, they could have stomach upset from cyclosporine modified and more thirst from prednisone. But using both together doesn’t seem to raise the chance of having more side effects. Talk to your vet about the risks and benefits of using both for your dog.

No. Cyclosporine modified isn’t a steroid. Instead, it’s a type of immunosuppressant called a calcineurin inhibitor. Both types of medications calm the immune system and reduce inflammation. But they work in different ways. Sometimes, pets might need to take cyclosporine modified and a steroid like prednisone at the same time. This combination can sometimes help treat their condition better.

No. Cyclosporine modified isn’t an antibiotic. It doesn’t treat bacterial infections. Instead, this medication works by weakening the immune system to reduce inflammation. This can actually make your pet more likely to get infections. If your pet gets an infection while taking cyclosporine modified, they might need antibiotics to treat it.

No. Cyclosporine modified and the unmodified version of cyclosporine (Sandimmune) are not the same. In fact, vets don’t use the unmodified form of cyclosporine for dogs or cats. This is because the way that it’s absorbed into the body is too inconsistent and it might not be safe for pets. You can’t switch back and forth between the modified and unmodified versions of cyclosporine. Make sure your pet is getting cyclosporine modified, not the unmodified version. Ask your vet or pharmacist if you have more questions.

It depends on the type of vaccine. So, ask your vet about which ones are okay while your pet is taking cyclosporine modified. This medication might affect how well some vaccines work to prevent serious illness in pets. Some vaccines, like the rabies vaccine, should still work well for your pet. But live virus vaccines might not work as well. Your vet can help decide which vaccines are okay and explain the risks and benefits.

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Risks and warnings for Cyclosporine modified for pets

Cyclosporine modified can cause some serious health issues. This risk might be even higher for certain pets. If this worries you, talk to your veterinarian about other options.

Risk of infections

  • Risk factors: Pets that get sick often | Pets with a current infection | Cats with feline immunodeficiency virus (FIV) or FeLV infection | Taking other medications that lower the immune system

Cyclosporine modified works by calming down your pet’s immune system. But this can also make it easier for them to get sick. Sometimes, these infections can be serious. Some infections your pet might get are urinary tract infections (UTIs) and respiratory tract infections. This medication might also be linked to a serious infection in cats called toxoplasmosis.

Be careful giving cyclosporine modified to pets that already have an infection. This is because the medication can slow healing and make the infection get worse. Also watch your pet closely if they’re taking other medications that weaken the immune system.

Call a vet if you see signs of infection in your pet. Watch for fever, low energy, pain, coughing, trouble breathing, runny nose, and eye problems. Also take note if your pet doesn’t seem to want to eat or has trouble urinating.

Possible risk of cancer

  • Risk factors: History of cancer | Taking other medications that lower the immune system | Taking cyclosporine modified for a long time

Cyclosporine modified can change the way the immune system works. It’s not clear if this affects cancer risk in pets at recommended doses. But it’s important to be aware of this risk. Pets that have cancer can’t take this medication because it might not be safe for them.

One type of cancer that dogs and cats have had while taking cyclosporine modified is lymphoma. Call your vet if you notice your pet has swollen lymph nodes, low energy, fever, or low appetite. These could be signs of cancer.

Liver problems

  • Risk factors: Low appetite | Cats that have low appetite or weight loss as side effects | Cats that are considered obese

Cats taking cyclosporine modified might eat less and lose weight as side effects. Although rare, these side effects can raise the risk of certain liver problems. The risk of liver problems is also possible but uncommon in dogs.

Tell your vet if your pet loses a lot of weight (more than 25% of their starting weight). Other signs of liver problems include being very tired, vomiting, a weak neck, and yellow eyes or skin. Talk to a vet right away if your pet shows any of these signs while taking cyclosporine modified.

Caution use in pets with kidney problems

  • Risk factors: Pets taking very high doses of cyclosporine modified | Pets with kidney failure

Pets with kidney problems or those taking high doses of cyclosporine modified might be at risk of kidney damage. These pets should take this medication with caution. Tell your vet if your pet has kidney problems before starting treatment.

Talk to a vet if you see signs of kidney problems in your pet while they’re taking cyclosporine modified. Watch for thirst, urinating more than usual, vomiting, not wanting to eat, and signs of dehydration.

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Cyclosporine modified dosage forms for pets

The average cost for 30 capsules of 100mg of Cyclosporine modified is $42.05 with a free GoodRx coupon. This is 54.37% off the average retail price of $92.16.
bottle of oral solutionBottle of oral solution
DosageQuantityPrice as low asPrice per unit
50ml of 100mg/ml1 bottle$79.99$79.99
capsuleCapsule
DosageQuantityPrice as low asPrice per unit
50mg30 capsules$24.50$0.82
25mg30 capsules$15.41$0.51
100mg30 capsules$42.05$1.40

Typical dosage for Cyclosporine modified

The dose is based on your pet’s weight and the reason they need to take this medication.

Follow your vet’s directions on how much and how often to give cyclosporine modified to your pet. Below are some examples for a few health conditions.

  • For dogs

    • Skin allergies: The typical starting dose is 5 mg/kg by mouth every 24 hours.
    • Sores around the anus: The typical dose is 4 mg/kg to 8 mg/kg by mouth every 12 or 24 hours.
    • Inflammatory bowel disease (IBD): The typical dose is 5 mg/kg by mouth every 12 or 24 hours.
    • Immune-related blood problems: The typical starting dose is 7.5 mg/kg to 10 mg/kg by mouth every 12 hours.

  • For cats

    • Skin allergies: The typical starting dose is 7 mg/kg by mouth every 24 hours.
    • Pemphigus complex (autoimmune skin condition causing blisters on the face, ears, and feet): The typical dose is 5 mg/kg to 10 mg/kg by mouth every 24 hours.
    • Certain immune-related blood problems: The typical dose is 5 mg/kg by mouth every 24 hours. Some cats might need larger doses up to 20 mg/kg per day.

Note: The dose might be lower if your vet prescribes cyclosporine modified along with other medications, like ketoconazole or omega-3 fatty acids. Your vet might also change how often you give the medication, depending on how your pet is doing. Instead of once or twice a day, you might give it every other day, every 3 days, or just twice a week.

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Interactions between Cyclosporine modified and other drugs for pets

Cyclosporine modified might interact with certain medications or supplements. Always let your veterinarian know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that your pet is currently taking. The list below does not include all possible drug interactions with Cyclosporine modified. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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Cyclosporine modified contraindications for pets

Contraindications are specific health conditions or situations in which a pet should not take a medication due to safety concerns. If your pet has any of the following conditions or if any of the following apply to your pet, let your veterinarian know because Cyclosporine modified will not be safe for your pet to take.

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What are alternatives to Cyclosporine modified for pets?

There might be medications that your veterinarian can prescribe in place of Cyclosporine modified. Compare a few possible alternatives below.
Cyclosporine modified
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Used for:
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Cyclosporine modified images

Yellow E0933 - Cyclosporine (modified) 100mg Capsule
This medicine is Yellow Capsule Imprinted With "E0933".Yellow E0933 - Cyclosporine (modified) 100mg Capsule
Yellow E0933 - Cyclosporine (modified) 100mg Capsule
This medicine is Yellow Capsule Imprinted With "E0933".Yellow E0933 - Cyclosporine (modified) 100mg Capsule
Gray C100 - Cyclosporine (modified) 100mg Capsule
This medicine is Gray Capsule Imprinted With "C100".Gray C100 - Cyclosporine (modified) 100mg Capsule
White Pa20 - Cyclosporine (modified) 100mg Capsule
This medicine is White Capsule Imprinted With "Pa20".White Pa20 - Cyclosporine (modified) 100mg Capsule
White Pa20 - Cyclosporine (modified) 100mg Capsule
This medicine is White Capsule Imprinted With "Pa20".White Pa20 - Cyclosporine (modified) 100mg Capsule

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References

Best studies we found

American Animal Hospital Association. (2022). Vaccine overview and types.

American Veterinary Medical Association. (n.d.). Cancer in pets.

American Veterinary Medical Association. (n.d.). Toxoplasmosis.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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