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oxycodone / ibuprofen

Generic Combunox
Used for Pain
Used for Pain

Oxycodone/ibuprofen is a combination medication used to treat moderate-to-severe pain. Because it has a high risk of dependency, misuse, and overdose, it should only be used for a short period of time. This medication is no longer available because it was discontinued in the United States.

Reviewed by:
reviewer
Shifali Patel, PharmD
reviewer
Ashley Wong, PharmD
Last reviewed on January 10, 2022
BasicsFAQsInteractionsPricesMedicare
Oxycodone/ibuprofen is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
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What is Oxycodone/ibuprofen?

How Oxycodone/ibuprofen works

Are you looking for information on hydrocodone / ibuprofen (Vicoprofen) or oxycodone / acetaminophen (Percocet) instead?

Drug Facts

Common BrandsCombunox (brand no longer available)
Drug ClassOpioid / NSAID
Controlled Substance ClassificationSchedule II
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
faqs

Frequently asked questions about Oxycodone/ibuprofen

What is oxycodone/ibuprofen?
Oxycodone/ibuprofen is a combination medication that treats moderate-to-severe pain. Oxycodone is an opioid that binds to certain parts of your brain, called mu-opioid receptors, to change how you react to pain. This helps decrease how much pain you feel. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves pain, fever, and swelling. Oxycodone/ibuprofen should only be used for a short period of time (maximum of 7 days) because it has serious risks of stomach bleeds, stomach ulcers, abuse, misuse, and overdose.
Is oxycodone/ibuprofen still available?
No. Oxycodone/ibuprofen is no longer available as a brand or generic medication in the United States.
Why was oxycodone/ibuprofen discontinued?
It's unclear why oxycodone/ibuprofen was discontinued. According to the U.S. Food and Drug Administration (the FDA), oxycodone/ibuprofen wasn't discontinued because it was unsafe or didn't work well. It's possible that it was removed from the market due to the availability of newer and safer combination pain medications.
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interactions

Interactions between Oxycodone/ibuprofen and other drugs

Oxycodone/ibuprofen may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Oxycodone/ibuprofen. Please note that only the generic name of each medication is listed below.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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