provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Orladeyo Coupon - Orladeyo 28 capsules of 150mg carton

Orladeyo

berotralstat
Used for Hereditary Angioedema
Used for Hereditary Angioedema

Orladeyo (berotralstat) is a plasma kallikrein inhibitor. It's taken once daily to prevent swelling attacks in the body in adults and children 12 years and older with a genetic condition called hereditary angioedema (HAE). Orladeyo (berotralstat) is the only currently available HAE medication that's taken by mouth. Side effects include stomach pain, vomiting, and diarrhea, but they should get better over time as you continue to take the medication.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Cydnee Ng, PharmD
Last reviewed on December 17, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Orladeyo (berotralstat)?

What is Orladeyo (berotralstat) used for?

  • Prevention of hereditary angioedema (HAE) attacks in people 12 years and older

How Orladeyo (berotralstat) works

Orladeyo (berotralstat) is a plasma kallikrein inhibitor. It blocks the activity of kallikrein, which is a protein in your blood that's involved in causing swelling and pain related to hereditary angioedema (HAE). By lowering kallikrein activity, Orladeyo (berotralstat) can help prevent pain and swelling attacks in people with HAE.

Drug Facts

Common BrandsOrladeyo
Drug ClassPlasma kallikrein inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$39468.26(save 96.02%)
GoodRx discount
$1569.81
See prices
basics-icon

What are the side effects of Orladeyo (berotralstat)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach pain (16%)
  • Vomiting (12%)
  • Diarrhea (12%)
  • Headache (9%)
  • Heartburn (7%)

Other Side Effects

  • Back pain
  • Fatigue
  • Passing gas

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Abnormal heart rhythm (QT prolongation): chest pounding, irregular heartbeat, chest pain, short of breath, feeling faint or lightheaded

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Orladeyo (berotralstat)

thumbs-up

Pros

Works well to prevent HAE attacks

The only HAE medication that's taken by mouth (i.e., not an injection)

Need to take only once per day

thumbs-down

Cons

Can't treat an HAE attack that's already happening

Can cause stomach upset (e.g., stomach pain, vomiting, diarrhea)

Can't use in children under 12 years old because it hasn't been studied yet

pharmacist-tips

Pharmacist tips for Orladeyo (berotralstat)

pharmacist

  • Orladeyo (berotralstat) is only meant to be used to prevent HAE attacks, so you should have a different medication on hand to use if you experience a sudden HAE attack.

    • Take Orladeyo (berotralstat) exactly as prescribed and at the same time every day with food. Don't take more doses or higher doses than prescribed because this can raise your risk for side effects, including a serious and potentially life-threatening heart rhythm problem (QT prolongation).

      • Don't open, crush, or chew the capsules. Contact your provider if you're having trouble swallowing the capsules. You might need to switch to a different medication to help prevent HAE attacks.

        • Side effects like stomach upset and heartburn typically get better or go away with time as you continue to take Orladeyo (berotralstat). Talk to your provider if any side effects become too bothersome. Your provider can recommend treatment options to ease these side effects or suggest to lower your Orladeyo (berotralstat) dose.

          • Don't start any new medications while you're taking Orladeyo (berotralstat) without asking your provider or pharmacist first. Orladeyo (berotralstat) can interact with other medications, such as digoxin (Lanoxin) and cyclosporine (Sandimmune or Neoral). Your providers can check for interactions to make sure your medications are safe to take.

            • Let your provider know if you're pregnant, planning to become pregnant, or breastfeeding before you start taking Orladeyo (berotralstat). It's not known whether the medication can harm your unborn baby or pass into breast milk because it hasn't been studied.

              faqs

              Frequently asked questions about Orladeyo (berotralstat)

              How well does Orladeyo (berotralstat) work?
              In clinical studies, people who took Orladeyo (berotralstat) for two years had a little over 90% fewer number of HAE attacks. In studies, people had an average of about three HAE attacks per month before they started treatment. And within 6 months of treatment, they started to see a lower number of attacks (average of one HAE attack per month). Keep in mind that everyone responds differently to medication, and Orladeyo (berotralstat) isn't guaranteed to always prevent HAE attacks. Follow up with your provider to discuss how well Orladeyo (berotralstat) is working for you.
              Can Orladeyo (berotralstat) prevent HAE attacks?
              Yes, Orladeyo (berotralstat) is used to prevent HAE attacks from happening, but it doesn't treat an active attack. Call 911 right away if you experience an HAE attack during your Orladeyo (berotralstat) treatment course.
              How do you take Orladeyo (berotralstat)?
              Take Orladeyo (berotralstat) by mouth once per day. It should be taken at the same time every day. Also make sure to take Orladeyo (berotralstat) with food; this can help with stomach-related side effects, like stomach pain or diarrhea.
              What's the difference between Orladeyo (berotralstat) and Takhzyro?
              Both Orladeyo (berotralstat) and Takhzyro (lanadelumab) are plasma kallikrein inhibitors that are used for preventing HAE attacks in people 12 years of age and older. The biggest difference is that Takhzyro (lanadelumab) is a biologic medication that's injected under the skin every 2 or 4 weeks and Orladeyo (berotralstat) is taken by mouth once per day. A 2023 study that indirectly compared both medications suggests that Takhzyro (lanadelumab) might work better than Orladeyo (berotralstat) at preventing HAE attacks. Talk to your provider about which medication is right for you.
              Can Orladeyo (berotralstat) be used in children under 12 years old?
              No, it's not known whether Orladeyo (berotralstat) is safe or works well in children under 12 years old because it hasn't been studied. But the manufacturer of Orladeyo (berotralstat) is currently studying the medication in children ages 2 to under 12 years. Talk to your child's provider about available options for preventing HAE, such as Cinryze or Haegarda. These medications can be used for children 6 years and older.
              GoodRxEducationalIcon

              How to save using GoodRx

              Compare Prices
              1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
              Select your free coupon
              2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
              Show coupon to your pharmacist
              3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
              Get free couponLearn more
              warings-icon

              What are the risks and warnings for Orladeyo (berotralstat)?

              Orladeyo (berotralstat) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Life-threatening abnormal heart rhythm (QT prolongation) with higher-than-recommended doses

              • Risk factors: Taking more than 150 mg of Orladeyo (berotralstat) per day | History of heart problems, slow heart rate, or other abnormal heart rhythms (arrhythmias) | Personal or family history of long QT syndrome | Abnormal electrolyte levels | Taking other medications that cause QT prolongation

                Taking more than the daily recommended dose — 150 mg of Orladeyo (berotralstat) per day — can raise your risk of a serious and potentially life-threatening heart rhythm problem called QT prolongation, or long QT syndrome. This happens when your heart doesn't contract and relax when it's supposed to, which can lead to an abnormal heart rhythm.

                Let your providers know about your medical history and all the medications you take so they can check your risk for QT prolongation. Your risk might be higher if you have other heart rhythm problems or if you take medications that also cause QT prolongation.

                Call your provider right away if you accidentally took more than your prescribed dose of Orladeyo (berotralstat). And call 911 right away if you experience chest pain, shortness of breath, lightheadedness, or abnormal heart rhythm.

                dosage

                Orladeyo (berotralstat) dosage forms

                The average cost for 28 cartons of 28 capsules of 150mg of Orladeyo (berotralstat) is $1569.81 with a free GoodRx coupon. This is 96.02% off the average retail price of $39468.26.
                carton
                Carton
                DosageQuantityPrice as low asPrice per unit
                28 capsules of 110mg28 cartons$1569.81$56.06
                28 capsules of 150mg28 cartons$1569.81$56.06

                Typical dosing for Orladeyo (berotralstat)

                The typical dose is 150 mg by mouth once daily with food.

                Your dose might differ if you have liver problems or if you're having side effects that don't go away with time.

                drug-cost

                How much does Orladeyo (berotralstat) cost?

                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                Orladeyo (brand)
                GoodRx lowest price

                $1569.81

                (save 96.02%)
                View prices & coupons
                alternatives

                What are alternatives to Orladeyo (berotralstat)?

                There are a number of medications that your doctor can prescribe in place of Orladeyo (berotralstat). Compare a few possible alternatives below.
                Orladeyo (berotralstat)
                Used for:

                • Prevention of hereditary angioedema (HAE) attacks in people 12 years and older

                $1569.81 Lowest GoodRx priceView Prices
                Haegarda
                Used for:

                • Prevention of hereditary angioedema (HAE) attacks in people 6 years and older

                $28936.74 Lowest GoodRx priceView Prices
                Cinryze
                Used for:
                View Prices
                images

                Orladeyo (berotralstat) images

                Blue And White Bcx 150 - Orladeyo 150mg Capsule
                This medicine is Blue And White Carton Imprinted With "Bcx 150".Blue And White Bcx 150 - Orladeyo 150mg Capsule

                Get savings updates for Orladeyo (berotralstat)

                Receive price alerts, news, and other messages from GoodRx about Orladeyo (berotralstat) and other healthcare topics and relevant savings offers.

                By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                References

                Best studies we found

                BioCryst Pharmaceuticals, Inc. (2023). BioCryst begins enrollment in pivotal APeX-P trial evaluating Orladeyo® (berotralstat) in pediatric patients with hereditary angioedema. Globe Newswire.

                BioCryst Pharmaceuticals, Inc. (2023). Orladeyo- berotralstat hydrochloride capsule [package insert]. DailyMed.

                Farzam, K., et al. (2023). QT prolonging drugs. StatPearls.

                View All References (5)

                Jean-Baptiste, M, et al. (2022). The symptom experience of hereditary angioedema (HAE) patients beyond HAE attacks: Literature review and clinician interviews. Orphanet Journal of Rare Diseases.

                Kiani-Alikhan, S., et al. (2023). Once-daily oral berotralstat for long-term prophylaxis of hereditary angioedema: The open-label extension of the APeX-2 randomized trial.

                National Heart, Lung, and Blood Institute. (2022). Long QT syndrome.

                U.S. Hereditary Angioedema Association. (n.d.). About hereditary angioedema.

                Watt, M., et al. (2023). Network meta-analysis for indirect comparison of lanadelumab and berotralstat for the treatment of hereditary angioedema. Journal of Comparative Effectiveness Research.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                Was this page helpful?

                Browse medications

                View All

                Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.