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Cinryze Coupon - Cinryze 500 units vial

Cinryze

human C1 esterase inhibitor
Used for Hereditary Angioedema
Used for Hereditary Angioedema

Cinryze is a C1 esterase inhibitor. It's used to help prevent swelling and painful attacks in people 6 years of age or older with hereditary angioedema (HAE). Cinryze is infused into the vein, typically every 3 to 4 days, by a healthcare provider. But if appropriate, your provider can train you to do the infusion at home. Common side effects of this medication include headache, nausea, rash and vomiting. Cinryze is only available at certain pharmacies.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Connie Zheng, PharmD
Last reviewed on November 20, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Cinryze?

What is Cinryze used for?

How Cinryze works

Cinryze is a C1 esterase inhibitor replacement. It contains C1 esterase inhibitor, a protein in your blood that helps relieve swelling (inflammation). Hereditary angioedema (HAE) is a swelling condition caused by low levels of C1 esterase inhibitor. By raising and restoring the levels of C1 esterase inhibitor in the blood, Cinryze helps prevent swelling attacks from happening in people with HAE.

Are you looking for information on Haegarda (human C1 esterase inhibitor) subcutaneous injections or Berinert (human C1 esterase inhibitor) intravenous injection kit instead?

Drug Facts

Common BrandsCinryze
Drug ClassC1 esterase inhibitor replacement
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Cinryze?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (19%)
  • Nausea (18%)
  • Rash (10%)
  • Vomiting (10%)
  • Fever (5%)

Other Side Effects

  • Pain at the injection site
  • Redness
  • Itching
  • Dizziness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Allergic reaction: hives, chest tightness, difficulty breathing, wheezing, fast heartbeat, swelling of the tongue or throat
  • Blood clot: pain, swelling, warmth, or discoloration of the arm or leg, unexplained shortness of breath, chest pain or discomfort, unexplained fast heartbeat, numbness or weakness on one side of the body

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Cinryze

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Pros

Can be given to adults and children 6 years or older

Given every 3 to 4 days

Can be refrigerated or stored at room temperature

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Cons

Has to be given intravenously

Can't be prepared more than 3 hours in advance

Can't be used to treat HAE attacks (can only prevent them)

pharmacist-tips

Pharmacist tips for Cinryze

pharmacist

  • Don't use Cinryze until you or your caregiver has been trained by a healthcare provider. Review the instructions on how to prepare and give Cinryze properly.

    • Do your best to keep everything clean and free of germs when reconstituting (or mixing) Cinryze. Always wash your hands before preparing. Always finish preparing the medication as soon as possible after opening the vials. This will help lower the risk of contamination and infections.

      • Before giving yourself a dose, allow Cinryze and the sterile water for injection to slowly reach room temperature. Don't microwave them or boil them because this might damage the medication.

        • Make sure Cinryze is free of particles and looks colorless to slightly blue. If it looks different, don't use it and contact your provider.

          • Cinryze is injected into a vein, most commonly in your arm on the inside of your elbow. Follow your provider's instructions on how to do this safely.

            • Make sure that you or your caregiver know how to use epinephrine (EpiPen) in case of an allergic reaction from Cinryze. Though rare, it's possible to have a serious allergic reaction to this medication. Symptoms can include hives, tightness in the chest, and trouble breathing.

              • Talk to your provider if you're confused about the symptoms of a HAE attacks compared to those of an allergic reaction to this medication. Signs of an HAE attack are different in each person, but can commonly cause swelling. An allergic reaction can also cause swelling, but might also include a rash, hives, trouble breathing, chest tightness, or fast heartbeat.

                • Each vial of Cinryze should only be used once. If you don't use all of the medication after one dose, you should throw it away. This is because Cinryze is free of preservatives, so germs can grow in it once it's opened.

                  • Place all of the needles in a sharps container after using Cinryze. This will help prevent needlestick injuries.

                    • Stop using Cinryze and let your provider know right away if you experience an allergic reaction or signs of a blood clot.

                      • Before traveling, make sure you talk to your provider to get enough medication to last you through your trip.

                        faqs

                        Frequently asked questions about Cinryze

                        What's the difference between Cinryze and Ruconest?
                        Both Cinryze and Ruconest are C1 esterase inhibitors. The main difference is that Cinryze is used to prevent HAE attacks, whereas Ruconest is given to treat attacks. In addition, Cinryze can be given to people ages 6 years and older, but Ruconest is only FDA-approved for people ages 13 years and older. Another difference is that Ruconest is made from rabbit milk, which might be important for people who have certain allergies.
                        Is Cinryze a biologic?
                        Yes, Cinryze is considered a biologic. It contains proteins taken from human plasma (the liquid portion of your blood).
                        Is there a generic for Cinryze?
                        No. Cinryze is currently only available as a brand-name medication.
                        Who can give Cinryze injections?
                        Cinryze is typically given by a healthcare provider. But if appropriate, your provider can train you or your caregiver to prepare and give Cinryze injections at home. Make sure you and your caregiver also learn how to use epinephrine (EpiPen) in case of an allergic reaction to the medication.
                        Can I prepare my Cinryze injections in advance?
                        Once prepared, Cinryze has to be used within 3 hours. Don't prepare your Cinryze injections until you're ready to use it.
                        How fast does Cinryze take to work?
                        Cinryze can raise the level of C1 esterase inhibitor in your blood within 1 hour of injection. But it can take a few weeks for your blood levels to stabilize. During 12-week clinical studies, most people taking Cinryze had less HAE attacks during the treatment period compared to those who didn't take the medication.
                        Does Cinryze need to be refrigerated?
                        Cinryze can be stored in a refrigerator or at room temperature between 36°F to 77°F (2°C to 25°C). If you refrigerate Cinryze, let the vials reach room temperature before you dissolve the powder with the sterile water that comes with the medication. Don't freeze Cinryze.
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                        What are the risks and warnings for Cinryze?

                        Cinryze can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                        risk-warning

                        Severe allergic reaction

                        Cinryze can cause severe allergic reactions in some people, so make sure your provider also prescribes epinephrine (EpiPen) for you to have during your injection, just in case. Get emergency medical help if you experience hives, chest tightness, difficulty breathing, wheezing, lightheadedness, fast heartbeat, or swelling of the tongue or throat.

                        risk-warning

                        Blood clots

                        • Risk factors: Current catheter or access device | History of blood clots | Buildup of fats in arteries | Taking birth control or androgens | Identified as obese | Not mobile

                          Blood clots have occurred in people who take Cinryze, even at the recommended dose. Let your provider know if you have any of the risk factors mentioned above, and they will determine if Cinryze is right for you. Get emergency medical help if you experience any signs of blood clots, such as pain, swelling, warmth, or discoloration of the arm or leg, unexplained shortness of breath, chest pain or discomfort, unexplained fast heartbeat, or numbness or weakness on one side of the body.

                          risk-warning

                          Transmission of diseases

                          Although rare, Cinryze has a risk of transmitting (spreading) certain viruses and diseases to you because this medication is made from human blood. Before Cinryze is made, blood donors are screened, the blood is tested for infections, and the blood product is processed to remove or inactivate certain viruses. Even though all these steps are taken to lower this risk, there's still a small risk of transmitting diseases. If you have concerns, speak to your provider.

                          dosage

                          Cinryze dosage forms

                          Typical dosing for Cinryze

                          • Adults and children 12 years and older: The typical dose is 1,000 international units (IU) injected intravenously (into the vein) at a speed of 1 mL/minute (over about 10 minutes) every three or four days. The maximum dose is 2,000 IU, but not more than 80 IU/kg of body weight, every three or four days.

                          • Children 6 to 11 years old: The typical dose is 500 IU injected intravenously at a speed of 1 mL/minute (over about 5 minutes) every three or four days. The maximum dose is 1,000 IU every three or four days.

                          alternatives

                          What are alternatives to Cinryze?

                          There are a number of medications that your doctor can prescribe in place of Cinryze. Compare a few possible alternatives below.
                          Cinryze
                          Used for:
                          View Prices
                          Haegarda
                          Used for:

                          • Prevention of hereditary angioedema (HAE) attacks in people 6 years and older

                          $28935.48 Lowest GoodRx priceView Prices
                          Orladeyo (berotralstat)
                          Used for:

                          • Prevention of hereditary angioedema (HAE) attacks in people 12 years and older

                          $44312.36 Lowest GoodRx priceView Prices
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                          Cinryze images

                          This medicine is Colorless Vial.
                          This medicine is Colorless Vial.

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                          References

                          Best studies we found

                          Caliezi, C., et al. (2000). C1-esterase inhibitor: An anti-inflammatory agent and its potential use in the treatment of diseases other than hereditary angioedema. Pharmacological Reviews.

                          National Organization for Rare Disorders. (2021). Hereditary angioedema.

                          Takeda Pharmaceuticals America, Inc. (2023). Cinryze- human c1-esterase inhibitor injection, powder, lyophilized, for solution; human c1-esterase inhibitor kit [package insert]. DailyMed.

                          View All References (2)

                          Takeda Pharmaceuticals U.S.A. Inc. (2023). Preparation and self‑administration instructions.

                          US Hereditary Angioedema Association. (n.d.). About hereditary angioedema.

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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