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Haegarda

human C1 esterase inhibitor

Used for Hereditary Angioedema

Haegarda is an injectable medication made from human blood products that's used to prevent swelling attacks from a condition called hereditary angioedema (HAE). You can give yourself the injection or ask a caregiver at home, but it has to be mixed before it's given.

Reviewed by:

Yen Nguyen, PharmD

Kristianne Hannemann, PharmD

Last reviewed on January 18, 2022

Basics Side effects Pros & cons Pharmacist tips FAQs Warnings Dosage Cost Alternatives Latest news Prices Medicare

What is Haegarda?

What is Haegarda used for?

Prevention of hereditary angioedema (HAE) attacks in people 6 years and older

How Haegarda works

Haegarda is a C1 esterase inhibitor replacement. It contains C1 esterase inhibitor, a protein in your blood that helps relieve swelling (inflammation). Hereditary angioedema (HAE) is a swelling condition caused by poorly functioning or low levels of C1 esterase inhibitor. By raising and restoring the levels of C1 esterase inhibitor in the blood, Haegarda helps prevent swelling attacks from happening.

Are you looking for information on Cinryze (human C1 esterase inhibitor) intravenous injection solution or Berinert (human C1 esterase inhibitor) intravenous injection kit instead?

Drug Facts

Common BrandsHaegarda

Drug ClassC1 esterase inhibitor replacement

Controlled Substance ClassificationNot a controlled medication

Generic StatusNo lower-cost generic available

AvailabilityPrescription only

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Avg retail price

$39515.70(save 51.75%)

GoodRx discount

$19066.05

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What are the side effects of Haegarda?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Injection site reaction (e.g., pain, swelling, itching; 35%)
Nose and throat infection (19%)
Allergic reaction (e.g., rash, itching; 7%)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.

Severe allergic reaction: hives, chest tightness, difficulty breathing, wheezing, fast heartbeat, swelling of the tongue or throat
Blood clot: pain, swelling, warmth, or discoloration of the arm or leg, unexplained shortness of breath, chest pain or discomfort, unexplained fast heartbeat, numbness or weakness on one side of the body

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

Fever
Headache
Nausea
Skin rash
Vomiting

Pros and cons of Haegarda

Pros

Only needs to be given 2 times a week

Injections can be given at home

Most people experience mild side effects.

Doesn't need to be refrigerated

Cons

Needs to be mixed before use

Injection might be uncomfortable

Only available as a brand medication, so it might be expensive

Can't be used to treat sudden HAE attacks

Pharmacist tips for Haegarda

Before using Haegarda, make sure you know how to prepare and give the injection. Review and follow these instructions. If you have questions, contact your pharmacist or healthcare provider.

Haegarda has to be reconstituted (or mixed) with sterile water before you can use it. The sterile water should be included with the medication. After mixing Haegarda, use the medication within 8 hours. Keep it at room temperature and don't refrigerate it.

You can inject Haegarda under the skin in your stomach or other site you've discussed with your provider. Don't inject in areas that are itchy, swollen, painful, bruised, or red. Avoid areas with scars or stretch marks.

Make sure you rotate your injection sites at least 2 inches away from the last place you gave the injection so that the same spot isn't used all the time. This will lessen the chance of getting a reaction in the injection area.

Use a new needle each time you inject Haegarda. Don't reuse or share your needles to avoid getting an infection.

Make sure that you or your caregiver knows how to use epinephrine (Epipen) in case of an allergic reaction from Haegarda.

Store Haegarda in its original packaging until ready to use to protect it from light.

Let your provider know if you're pregnant, planning to become pregnant, or breastfeeding while taking Haegarda to discuss if this medication is safe for you and your baby.

Before traveling, make sure you talk to your provider to get enough medication to last you through your trip.

Frequently asked questions about Haegarda

Can I use Haegarda at home?

Yes, you or your caregiver can give Haegarda injections at home. It's important to be trained on how to properly prepare and give Haegarda injections, as well as how to use epinephrine (Epipen) in case of an allergic reaction to the medication.

Can Haegarda be used to treat HAE attacks?

No, Haegarda is only given to prevent HAE attacks from occurring. Speak to your provider about other medications to treat your HAE attacks.

Can Haegarda prevent all of my HAE attacks?

Although Haegarda can't prevent all HAE attacks, HAE attacks are typically lowered by 95% in people who take this medication. Make sure you have other medications ready in case you experience an HAE attack.

How fast does Haegarda take to work?

Haegarda can start raising the levels of C1 inhibitor in your blood right away, but it might take a couple of weeks for your levels to stabilize.

Do I need to change my dose of Haegarda if my weight changes?

If you experience a significant change in your weight, talk to your provider so they can help you calculate a new dose of Haegarda. Always let your provider know if you have any factors that can affect your weight, such as a change in diet or exercise, life events, or health problems.

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What are the risks and warnings for Haegarda?

Haegarda can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Severe allergic reaction

Haegarda can cause severe allergic reactions in some people, so make sure your provider also prescribes epinephrine (Epipen) for you to have during your injection of this medication. Get emergency medical help if you experience hives, chest tightness, difficulty breathing, wheezing, lightheadedness, fast heartbeat, or swelling of the tongue or throat.

Blood clots

Risk factors: High dose of C1 inhibitor given as an injection through your veins (intravenous) | History of blood vessel or heart problems | History of stroke or blood clots | Current catheter or access device | Not mobile

Although it's not clear if Haegarda can cause blood clots, blood clots have occurred in people who get high doses of C1 inhibitors through intravenous (IV) injections. Get emergency medical help if you experience any signs of blood clots, such as pain, swelling, warmth, or discoloration in your arm or leg, unexplained shortness of breath, chest pain or discomfort, unexplained fast heartbeat, or numbness or weakness on one side of your body.

Transmission of diseases

Although rare, Haegarda has a risk of transmitting (spreading) certain viruses and diseases to you because this medication is made from human blood. Before Haegarda is made, blood donors are screened, the blood is tested for infections, and the blood product is processed to remove or inactivate certain viruses. Even though all these steps are taken to lower this risk, there is still a small risk of transmitting diseases. If you have concerns, speak to your provider.