Takhzyro
Takhzyro (lanadelumab or lanadelumab-flyo) is an injectable medication used to prevent swelling attacks in the body from a condition called hereditary angioedema (HAE) in adults and children 12 years and older. It's available as ready-to-use vials and prefilled syringes, so it doesn't have to be mixed before use.
What is Takhzyro (lanadelumab)?
What is Takhzyro (lanadelumab) used for?
- Prevention of HAE attacks in people 12 years and older
How Takhzyro (lanadelumab) works
Takhzyro (lanadelumab) is a monoclonal antibody that's in a group of medications called plasma kallikrein inhibitors. It blocks the activity of a protein in your blood called plasma kallikrein.
Plasma kallikrein is more active in people with hereditary angioedema (HAE) and raises the production of bradykinin, a substance that's responsible for pain and swelling. By lowering plasma kallikrein activity, Takhzyro (lanadelumab) can help prevent pain and swelling attacks in people with HAE.
Drug facts
Side effects of Takhzyro (lanadelumab)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Injection site reactions (e.g., pain, redness, bruising, 52%)
- Upper respiratory infection (i.e., common cold, 29%)
- Headache (21%)
- Rash (7%)
- Dizziness (6%)
- Muscle pain (5%)
- Diarrhea (5%)
Less Common Side Effects
- Allergic reaction
- Rise in liver enzyme levels
Takhzyro (lanadelumab) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe allergic reaction: hives, chest tightness, difficulty breathing, wheezing, fast heartbeat, swelling of the tongue or throat
The following Takhzyro (lanadelumab) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Diarrhea
- Dizziness
- Headache
- Muscle pain
- Pain, redness, irritation, or bruising at the injection site
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Pros and cons of Takhzyro (lanadelumab)
Pros
- Doesn't require mixing
- Only needs to be given every 2 or 4 weeks
- Can choose between read-to-use vials or prefilled syringes
- Good choice for people who can't swallow pills
Cons
- Given by injection only, which might be uncomfortable
- Needs to be stored in the refrigerator
- Not recommended for children under 12 years old
- Can't be used to treat an HAE attack
Pharmacist tips for Takhzyro (lanadelumab)
- Before using Takhzyro (lanadelumab), make sure you know how to prepare and give the injection. Review and follow these instructions. If you have questions, contact your pharmacist or healthcare provider.
- Takhzyro (lanadelumab) shouldn't be used to treat HAE attacks since it only works to prevent attacks from happening. Continue to keep track of the other medications you use to treat attacks.
- If you're using the single-dose vial, make sure you give the injection within 2 hours of drawing up your dose. If you don't use it within 2 hours, you can refrigerate the syringe and use it within 8 hours.
- Each Takhzyro (lanadelumab) vial and prefilled syringe are for one time use only. Make sure you use a new vial or syringe for every dose, and throw away any unused medication that's left in a sharps container or puncture-resistant container.
- Use a new needle each time you inject Takhzyro (lanadelumab). Don't reuse or share your needles to avoid getting an infection.
- Store Takhzyro (lanadelumab) in the refrigerator and in its original packaging until ready to use to protect it from light. Don't freeze or shake the vials or syringes because this can damage the medication.
Common questions about Takhzyro (lanadelumab)
Yes, you can give yourself Takhzyro (lanadelumab) injections, or ask a caregiver to give it to you at home. Before your first injection, your provider will train you or your caregiver on how to properly prepare and give the injections. Be sure to read the instructions for use and if you have any questions contact your provider or pharmacist.
You can inject Takhzyro (lanadelumab) yourself under the skin into your stomach or thigh. If Takhzyro (lanadelumab) is given by a healthcare provider or caregiver, it can also be injected under the skin in the upper arm. Don't inject this medication into areas of the skin that are irritated, red, bruised, or infected. Make sure you inject it at least 2 inches away from any scars or your belly button. Each time you give the injection, make sure it's at least 1 inch away from the area you last used. This will help keep the skin healthy where you're injecting the medication.
Takhzyro (lanadelumab) is generally given every 2 weeks. Your provider might instruct you to give the injections every 4 weeks if your HAE symptoms are well controlled (free of attacks) for more than 6 months. Speak with your provider to see how often you need to inject Takhzyro (lanadelumab).
Yes, Takhzyro (lanadelumab) needs to be refrigerated until you're ready to use it. Before using Takhzyro (lanadelumab), take the medication out of the refrigerator for 15 minutes to allow it to reach room temperature. This medication is sensitive to warm temperatures, so don't use a microwave or hot water to warm up your vial or syringe.
You can still get your Takhzyro (lanadelumab) injections while traveling. Speak with your provider before your travel dates to make sure you have enough medication and supplies to last you through your trip. Review with your provider on what you need to pack, how to store your medication, and other TSA (transportation security administration) requirements.
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Risks and warnings for Takhzyro (lanadelumab)
Takhzyro (lanadelumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Serious allergic reaction
Takhzyro (lanadelumab) can cause serious allergic reactions in some people. Get emergency medical help if you experience hives, chest tightness, wheezing, lightheadedness, faintness, fast heartbeat, difficulty breathing, or swelling of the tongue or throat.
Takhzyro (lanadelumab) dosage
Syringe| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 150mg/ml | 1 syringe | $12,971.77 | $12,971.77 |
Typical dosage for Takhzyro (lanadelumab)
The typical starting dose is 300 mg injected under the skin every 2 or 4 weeks.
How much does Takhzyro (lanadelumab) cost?
$12,971.77
What are alternatives to Takhzyro (lanadelumab)?
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