Orenitram (treprostinil) is used to treat pulmonary arterial hypertension (PAH) to improve your ability to exercise. The medication is available as a tablet that's easy to take, but it needs to be taken two or three times a day. It's only available as a brand medication, which can make it expensive.
Pulmonary arterial hypertension (PAH)
Orenitram (treprostinil) is a prostacyclin analog, which means that it acts like prostacyclin. Prostacyclin is a natural hormone in your body that helps widen or open up the blood vessels leading to your lungs from your heart. This allows blood to flow better in the lungs, which lowers blood pressure in the lungs, helps your body get more oxygen, and helps the heart work more efficiently.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Convenient tablet version compared to the treprostinil (Remodulin) injection and the Tyvaso (treprostinil) inhalation
Okay to use if you have kidney problems
Can't be used if you have severe liver problems
Can be burdensome, because you have to take it either two or three times a day; some alternatives like tadalafil (Adcirca) are only taken once daily
Only available as a brand medication, so it can be expensive
Orenitram (treprostinil) has a tablet shell that doesn't get dissolved in your stool. Don't be alarmed if you see it in your stool.
Take Orenitram (treprostinil) with food, and don't chew, crush, split, or break it.
If you miss a dose and it's too close to your normal dose time, skip it, and take the next one at your normal time.
Keep Orenitram (treprostinil) in a safe place at room temperature.
Let your healthcare provider know if you develop any muscle cramps, heartbeats, or weakness that's not normal.
Orenitram (treprostinil) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Your symptoms of PAH can worsen if you lower your dose or stop taking Orenitram (treprostinil) suddenly. Don't lower your dose or stop taking the medication without talking to your provider first, so they can instruct you how to do this safely.
Risk factors: Diverticulosis
The tablet shell of Orenitram (treprostinil) doesn't dissolve, and you'll see it in your stool. If you have a condition known as diverticulosis or any conditions that cause gut blockages, the tablet shell can get lodged in your gut. Let your healthcare provider know if you have problems with your gut before starting Orenitram (treprostinil).
The typical starting dose is either:
0.125 mg by mouth three times daily (every 8 hours) with food, or
0.25 mg by mouth twice daily (every 12 hours) with food
Your healthcare provider may raise your dose every 3 to 4 days until the dose is right for you.
Pulmonary arterial hypertension (PAH)
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