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Tadalafil (Adcirca) Coupon - Tadalafil (Adcirca) 20mg tablet

tadalafil

Generic Adcirca
Used for Pulmonary Hypertension
Used for Pulmonary Hypertension

Tadalafil (Adcirca) is a phosphodiesterase 5 (PDE-5) blocker. It's used to improve exercise ability in adults who have high blood pressure in the lungs, also known as pulmonary arterial hypertension (PAH). It's taken by mouth once daily. Tadalafil for PAH is available as tablets (Adcirca, Alyq) and an oral suspension (Tadliq). Side effects of tadalafil (Adcirca) are typically mild and temporary, and can include headache and muscle pain.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on December 17, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Tadalafil (Adcirca)?

What is Tadalafil (Adcirca) used for?

  • Pulmonary arterial hypertension (PAH)

How Tadalafil (Adcirca) works

Tadalafil (Adcirca) is a phosphodiesterase 5 (PDE-5) blocker that relaxes blood vessels in the lungs. This allows blood to flow better and lowers blood pressure in the lungs. As a result, your heart is able to pump better and bring more oxygen to your body. This can help you breathe and exercise more easily.

Are you looking for information on tadalafil (Cialis) for erectile dysfunction instead?

Drug Facts

Common BrandsAdcirca, Alyq, Tadliq
Drug ClassPDE-5 inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Tadalafil (Adcirca)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (42%)
  • Muscle pain (14%)
  • Runny nose or sore throat (13%)
  • Flushing (13%)
  • Cold, bronchitis, and other respiratory infections (13%)
  • Pain in hands and feet (11%)
  • Nausea (11%)
  • Back pain (10%)
  • Upset stomach (10%)
  • Stuffy nose (9%)

Other Side Effects

  • Hearing loss
  • Visual changes
  • Migraine
  • Seizures
  • Memory problems

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Eye problems: poor eyesight, loss of vision in one or both eyes
  • Hearing problems: sudden loss of hearing, ringing in the ears, dizziness
  • Erection lasting for more than 4 hours
  • Low blood pressure: dizziness or lightheadedness, nausea, lack of concentration, shallow and fast breathing, tiredness, unusual thirst, fainting
  • Fluid build up in the lungs: tiredness during physical activity, dizziness, low energy, trouble breathing (especially when lying down), cough, bluish tint to the skin, chest pain

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Arm, back, or jaw pain

blurred vision

chest pain, discomfort, tightness, or heaviness

chills

cold sweats

confusion

dizziness

fainting

faintness or lightheadedness when getting up suddenly from a lying or sitting position

fast or irregular heartbeat

headache

hearing loss

increased erection

nausea

nervousness

pain or discomfort in the arms, jaw, back, or neck

pounding in the ears

slow or fast heartbeat

spontaneous penile erection

sweating

unusual tiredness or weakness

vomiting

Rare

Painful or prolonged erection of the penis

Incidence not known

Blindness

blistering, peeling, or loosening of the skin

cough

cracks in the skin

decrease or change in vision

diarrhea

difficulty with speaking

double vision

fast, irregular, pounding, or racing heartbeat or pulse

headache, severe and throbbing

hives or welts, itching, skin rash

inability to move the arms, legs, or facial muscles

inability to speak

joint or muscle pain

loss of heat from the body

numbness or tingling of the face, hands, or feet

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

redness of the skin

redness or soreness of the eyes

scaly skin

slow speech

sores, ulcers, or white spots in the mouth or on the lips

stomach pain

sudden cardiac death

swelling of the feet or lower legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Belching

heartburn

indigestion

stomach discomfort, upset, or pain

Less common

Bloody nose

body aches or pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

burning, dry, or itching eyes

burning feeling in the chest or stomach

congestion

difficulty with moving

difficulty with swallowing

dry mouth

dryness or soreness of the throat

excessive eye discharge

eye pain

feeling of constant movement of self or surroundings

feeling of warmth, redness of the face, neck, arms and occasionally, upper chest

fever

hoarseness

lack or loss of strength

loose stools

muscle aching, cramping, or stiffness

neck pain

pain in the arms or legs

pain or burning in the throat

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

reduced sensitivity to touch

runny or stuffy nose

sensation of spinning

sleepiness or unusual drowsiness

stomach upset

swelling of the eyelids

swelling or puffiness of the eyes or face

swollen joints

tearing

tender, swollen glands in the neck

tenderness in the stomach area

trouble with sleeping

upper stomach pain

voice changes

watering of the eyes

Rare

Changes in color vision

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Tadalafil (Adcirca)

thumbs-up

Pros

Helps improve your ability to exercise or do physical activity

Only taken once daily - less often than other PDE-5 inhibitors for PAH, such as sildenafil (Revatio)

Can be taken with or without food

thumbs-down

Cons

Can take several months for you to notice benefit from this medication

Interacts with several common medications, including blood pressure and prostate medications

Can't take with certain ED medications like sildenafil (Viagra) or tadalafil (Cialis)

pharmacist-tips

Pharmacist tips for Tadalafil (Adcirca)

pharmacist

  • Tadalafil (Adcirca) can be taken with or without food.

    • Take tadalafil (Adcirca) at the same time every day. If you're taking the tablets and your dose is 40 mg, you should take two 20 mg tablets at the same time. It's not recommended to split up the 40 mg dose into two separate doses throughout the day.

      • If you're taking Tadliq (tadalafil) oral suspension, use a dosing syringe or medication cup to measure your dose in milliliters. Household spoons should never be used to measure medications because they might be inaccurate, even if you're specifically using a teaspoon or tablespoon. Talk to your pharmacist or prescriber if you don't have a proper dosing device.

        • Try to avoid drinking alcohol when you're taking tadalafil (Adcirca) since it can drop your blood pressure too much or make you more dizzy and lightheaded.

          • Don't take tadalafil (Adcirca) with grapefruit juice. Doing so can raise your risk of side effects (such as headache, nausea, and even dangerous drops in blood pressure).

            • Tadalafil (Adcirca) contains the same active ingredient as tadalafil (Cialis), which is used for ED or enlarged prostate. Don't take tadalafil (Adcirca) together with Cialis or any other treatments for ED (PDE-5 inhibitors) as this raises the risk of serious side effects, such as headache or vision problems.

              • If you have an erection for more than 4 hours, get medical attention right away because this can cause permanent damage if it's not treated.

                faqs

                Frequently asked questions about Tadalafil (Adcirca)

                Does tadalafil (Adcirca) lower blood pressure?
                Tadalafil (Adcirca) might cause a very small drop in blood pressure. But this is temporary and you're not likely to have any noticeable symptoms. But you will experience a larger drop in blood pressure if you're also taking other medications that have the same effect, such as metoprolol (Lopressor), doxazosin (Cardura), or tamsulosin (Flomax). Your prescriber will ask you to check your blood pressure more often when you first start tadalafil (Adcirca). If your blood pressure drops too low, you might notice symptoms like dizziness, blurry vision, or weakness. Let your healthcare team know if you have these side effects because they might need to make changes to your medication.
                Can you drink alcohol while taking tadalafil (Adcirca)?
                It's best to avoid drinking alcohol when you're taking tadalafil (Adcirca). This combination can cause your blood pressure to drop too low, which can lead to side effects like dizziness and lightheadedness. Talk with you healthcare team if you have more questions about tadalafil (Adcirca) and alcohol.
                Can I take tadalafil (Adcirca) for erectile dysfunction?
                No, you shouldn't take tadalafil (Adcirca) for erectile dysfunction (ED). This medication is only FDA-approved for pulmonary arterial hypertension (PAH). While tadalafil is also the active ingredient in Cialis, which is approved to treat ED, the two formulations are prescribed for different conditions and at different doses. Typically, your healthcare team won't prescribe more than one form of tadalafil at a time. Taking multiple PDE-5 inhibitors at the same time can raise the risk of serious side effects, including dangerously low blood pressure and vision loss. If you have ED, talk with your healthcare team. They can talk with you about appropriate treatment options.
                What's the difference between tadalafil (Adcirca) and tadalafil (Cialis)?
                Both medications contain tadalafil as the active ingredient, but they're FDA-approved to treat different health conditions. Cialis is approved for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH), whereas Adcirca is approved to treat PAH. The dosages of tadalafil for these conditions are different, so it’s important to take tadalafil only as prescribed by your healthcare team. Taking it differently than prescribed can raise the risk of serious side effects.
                Is tadalafil (Adcirca) safe?
                Tadalafil (Adcirca) is generally safe when you take it as prescribed by your healthcare team. It can cause some side effects, like headache or muscle pain, but these are typically mild and go away with time. In clinical studies, very few people stopped taking tadalafil (Adcirca) because of side effects. However, like with other PDE-5 inhibitors, tadalafil (Adcirca) can cause some rare but serious side effects, including vision or hearing loss. Talk with your healthcare team right away if you notice changes in your vision, ringing in your ears, or dizziness.
                How well does tadalafil (Adcirca) work?
                Tadalafil (Adcirca) treats PAH by improving your ability to exercise. At the end of a 4-month long clinical trial, people who took tadalafil (Adcirca) were able to walk a longer distance in 6 minutes compared with people who took placebo. Talk with your pulmonologist or HCP if you have questions about how tadalafil (Adcirca) can help treat your PAH.
                What's the difference between Adcirca, Alyq, and Tadliq?
                Adcirca, Alyq, and Tadliq are all brand name medications that contain tadalafil for treating PAH. Adcirca and Alyq are tablets (Alyq is the FDA-approved generic version of Adcirca) and Tadliq is a liquid oral suspension. The liquid suspension might be a better option for people who have trouble swallowing pills. Talk with your healthcare team if you have more questions about tadalafil for PAH.
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                What are the risks and warnings for Tadalafil (Adcirca)?

                Tadalafil (Adcirca) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Low blood pressure

                • Risk factors: Low blood pressure | Taking alpha blockers, medications for high blood pressure, or chest pain (angina) | Drinking alcohol

                  Tadalafil (Adcirca) can cause temporary drops in blood pressure, especially in people with certain heart conditions or in people already taking blood pressure medications. This can make you feel dizzy and raise the risk for falls. Be very careful getting up from a sitting or lying down position. It's not recommended to take tadalafil (Adcirca) within 48 hours of taking nitrates for chest pain, as this can cause a dangerous drop in your blood pressure. Drinking alcohol can also cause low blood pressure, so avoid drinking alcohol when taking tadalafil (Adcirca). Let your prescriber know if you continue to feel dizzy or lightheaded after your dose.

                  risk-warning

                  Prolonged or painful erection (priapism)

                  • Risk factors: Sickle cell anemia | Multiple myeloma | Leukemia | Medical conditions that affect the penis

                    Although rare, there have been reports of males experiencing an erection lasting more than 4 hours (priapism) while taking PDE-5 inhibitors, like tadalafil (Adcirca). This can cause permanent damage to the penis if not treated in time. Get medical help right away if you have an erection that lasts longer than 4 hours or if you feel pain during an erection.

                    risk-warning

                    Vision changes

                    • Risk factors: Over age 50 | High blood sugar | High blood pressure | Heart disease | High cholesterol | Smoking | History of eye problems

                      If you suddenly notice changes in your vision, go to the emergency room or call your prescriber right away. Although rare, PDE-5 inhibitors can cause permanent eye damage. If your ophthalmologist has told you that you have a "crowded" optic disc, you might be at higher risk for vision changes with tadalafil (Adcirca). Tell your prescriber about your full medical history before taking tadalafil (Adcirca).

                      risk-warning

                      Hearing loss

                      Some people who took tadalafil reported experiencing hearing loss; it sometimes happens along with ringing in the ears (tinnitus) and dizziness. Go to the emergency room or call your prescriber right away if you notice changes in your hearing in one or both ears.

                      risk-warning

                      Avoid use with other PDE-5 inhibitors

                      Tadalafil is also marketed as tadalafil (Cialis). Don't take tadalafil (Adcirca) with other PDE-5 inhibitors as this can cause unsafe drops in blood pressure and a higher risk of side effects. Other PDE-5 inhibitors include: sildenafil (Viagra), vardenafil (Levitra), and avanafil (Stendra).

                      risk-warning

                      Risks with certain heart problems

                      • Risk factors: Pulmonary vascular occlusive disease (PVOD)

                        Tadalafil (Adcirca) isn't recommended if you have pulmonary vascular occlusive disease (PVOD). This is a rare condition that affects the blood flow between your lungs and heart. Tadalafil (Adcirca) hasn't been studied in people with PVOD, but it might make this condition worse. If you feel extreme tiredness or trouble catching your breath, get medical help right away.

                        dosage

                        Tadalafil (Adcirca) dosage forms

                        Typical dosing for Tadalafil (Adcirca)

                        Tadalafil tablet (Adcirca, Alyq):

                        • Adults: The typical dose is 40 mg by mouth once daily. Tadalafil (Adcirca) comes as 20 mg tablets, so you'll need to take two tablets to make your dose. Don't divide the dose over the course of the day.

                        Tadliq (tadalafil) oral suspension:
                        Each 5 mL (teaspoonful) of suspension contains 20 mg of tadalafil.

                        • Adults: The typical dose is 10 mL (two teaspoonfuls) by mouth once daily.

                        Your dose might be different if you have kidney or liver problems.

                        More on Tadalafil (Adcirca) dosage forms

                        adcirca: adcirca dosage

                        Adcirca (Tadalafil) Dosages: Your GoodRx Guide

                        Written by Austin Ulrich, PharmD, BCACP
                        interactions

                        Interactions between Tadalafil (Adcirca) and other drugs

                        Tadalafil (Adcirca) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Tadalafil (Adcirca). Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                        How much does Tadalafil (Adcirca) cost?

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                        contraindications-icon

                        Tadalafil (Adcirca) contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Tadalafil (Adcirca) will not be safe for you to take.
                        alternatives

                        What are alternatives to Tadalafil (Adcirca)?

                        There are a number of medications that your doctor can prescribe in place of Tadalafil (Adcirca). Compare a few possible alternatives below.
                        Tadalafil (Adcirca)
                        Used for:

                        • Pulmonary arterial hypertension (PAH)

                        $21.41 Lowest GoodRx priceView Prices
                        Sildenafil (Revatio)
                        Used for:

                        • Pulmonary arterial hypertension (PAH)

                        $7.48 Lowest GoodRx priceView Prices
                        images

                        Tadalafil (Adcirca) images

                        White Oval 20 - Tadalafil 20mg Tablet
                        This medicine is White, Oval Tablet Imprinted With "20".White Oval 20 - Tadalafil 20mg Tablet
                        White Oblong H And T15 - Tadalafil 20mg Tablet
                        This medicine is White, Oblong Tablet Imprinted With "H" And "T15".White Oblong H And T15 - Tadalafil 20mg Tablet
                        Orange Oval 990 - Tadalafil 20mg Tablet
                        This medicine is Orange, Oval Tablet Imprinted With "990".Orange Oval 990 - Tadalafil 20mg Tablet
                        Yellow Oval Rdy 20 - Tadalafil 20mg Tablet
                        This medicine is Yellow, Oval Tablet Imprinted With "Rdy 20".Yellow Oval Rdy 20 - Tadalafil 20mg Tablet

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                        References

                        Best studies we found

                        Al Othman, B., et al. (2024). Pseudopapilledema. American Academy of Ophthalmology.

                        BioSpace. (2019). Teva announces launch of ALYQ™ (tadalafil tablets USP), a generic version of ADCIRCA® in the United States. Business Wire.

                        CMP Pharma, Inc. (2022). Tadliq- tadalafil suspension [package insert]. DailyMed.

                        View All References (5)

                        Galiè, N., et al. (2009). Tadalafil therapy for pulmonary arterial hypertension. Circulation.

                        Henrie, A. M., et al. (2015). Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: An evidence-based review. Core Evidence.

                        MedlinePlus. (2015). Pulmonary veno-occlusive disease.

                        Teva Pharmaceuticals, Inc. (2023). Alyq- tadalafil tablet, film coated [package insert]. DailyMed.

                        United Therapeutics Corporation. (2024). Adcirca- tadalafil tablet [package insert]. DailyMed.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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