Treprostinil (Remodulin): Basics, Side Effects & Reviews

Treprostinil (Remodulin)

Basics, Side Effects, Reviews & More


Warning Icon Are you looking for information on Orenitram (treprostinil) tablet or Tyvaso (treprostinil) inhalation solution instead?

Treprostinil (Remodulin) is used to treat pulmonary arterial hypertension (PAH) to improve your ability to exercise. It's an injection that goes under your skin or into a vein, and it comes with a special pump to deliver the medication.






Not a controlled medication


Lower-cost generic available


Prescription only

Reviewed by:

Dalga Surofchy, PharmD, APh

Allison Barnes, PharmD

Last reviewed on:

February 6, 2021

What is treprostinil (Remodulin)?

How treprostinil (Remodulin) works

Treprostinil (Remodulin) is a prostacyclin analog, which means that it acts like prostacyclin. Prostacyclin is a natural hormone in your body that helps widen or open up the blood vessels leading to your lungs from your heart. This allows blood to flow better in the lungs, which lowers blood pressure in the lungs, helps your body get more oxygen, and helps the heart work more efficiently.

What is treprostinil (Remodulin) used for?

  • Pulmonary arterial hypertension (PAH)

Treprostinil (Remodulin) dosage forms

Typical dosing for treprostinil (Remodulin)

The dose of treprostinil (Remodulin) depends on your body weight. The typical starting dose is 1.25 nanograms (ng)/kg/minute injected underneath your skin or into a vein using a special pump. Your healthcare provider will prescribe the right dose for you and explain how to use the pump.

Frequently asked questions about treprostinil (Remodulin)

Pros and cons of treprostinil (Remodulin)


Thumbs UpOne of the first choices in treating certain types of PAH

Thumbs UpCan help improve some heart symptoms and breathing problems associated with PAH during exercise


Thumbs DownDoesn't cure PAH

Thumbs DownInjected under the skin or into a vein

Thumbs DownCan cause pain at the injection site

Pharmacist tips for treprostinil (Remodulin)

Capsule IconTreprostinil (Remodulin) might need to be mixed with another fluid (diluent) before you use it. Your healthcare provider will show you if and how your medication needs to be mixed with a diluent.

Capsule IconAfter mixing treprostinil (Remodulin) with its diluent, make sure there are no flakes and that it's clear before using it. Otherwise, don't use the medication; it could be contaminated, and it won't be safe for you to use.

Capsule IconThrow away any treprostinil (Remodulin) vials that have been opened or stuck with a needle after 30 days.

Capsule IconDon't change the dose that your healthcare provider has prescribed to you, because you can experience shortness of breath, dizziness, or unusual weakness.

Capsule IconTreprostinil (Remodulin) can raise your risk of bleeding. If you notice a cut or any bleeding that doesn't stop, let your healthcare provider know and get medical help right away.

Capsule IconStore the unopened vial of treprostinil (Remodulin) in a dark, safe environment away from light and at room temperature.

Prices for treprostinil (Remodulin) start at just $ with a GoodRx coupon. They’re fast, easy-to-use and free!

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What are the side effects of treprostinil (Remodulin)?

With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.

Warning Small Contact your doctor immediately if you experience any of the following:

  • Allergic reaction

Caution Small The following side effects may get better over time as your body gets used to the medication. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time.

Common side effects

  • Pain at the injection site (85%)
  • Reactions at the injection site, like redness or irritation (83%)
  • Headache (27%)
  • Diarrhea (25%)
  • Nausea (22%)
  • Rash (14%)
  • Jaw pain (13%)
  • Dizziness or lightheadedness (11%)
  • Swelling of the hands or feet (9%)

*For injections delivered underneath the skin

Other side effects

  • Bleeding

Source: DailyMed

The following side effects have also been reported:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Accumulation of blood at the site of injection

dry, red, hot, or irritated skin

feeling faint, dizzy, or lightheaded

feeling of warmth or heat

flushing or redness of the skin, especially on the face and neck


redness, hardening of the skin, or rash at the site of injection


Less common

Blurred vision


dizziness, faintness, lightheadedness when getting up suddenly from a lying or sitting position

sudden sweating

unusual tiredness or weakness

Incidence not known

Black, tarry stools

bleeding gums

blood in the urine or stools

bone pain

changes in skin color, pain, tenderness, or swelling of the foot or leg

chest pain

decreased urine output

difficult or labored breathing

dilated neck veins

extreme tiredness or weakness

irregular breathing

irregular heartbeat

itching, pain, redness, swelling, or tenderness on the skin

paleness of the skin

pinpoint red spots on the skin

tightness in the chest

troubled breathing

unusual bleeding or bruising

weight gain

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Loss of consciousness


unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common



jaw pain


Less common

Lack or loss of strength

loss of appetite

stomach pain


weight loss

Incidence not known

Difficulty in moving


joint pain

muscle ache, cramp, pain, spasm, or stiffness

pain in the arms or legs swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What are the risks and warnings for treprostinil (Remodulin)?

Treprostinil (Remodulin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options

Bloodstream infections

  • Risk factors: Infusing treprostinil (Remodulin) into a vein

Infusing treprostinil (Remodulin) into your vein for a long time can potentially cause bloodstream infections. These infections can be life-threatening. To lower your risk of infections, wash your hands before using treprostinil (Remodulin), and make sure the area by your catheter is clean and pain-free. Infusions delivered underneath your skin is preferred, because there is a lower risk of bloodstream infections when the medication is delivered this way.

Worsening of PAH symptoms

Your symptoms of PAH can worsen if you lower your dose or stop taking treprostinil (Remodulin) suddenly. Make sure you have a backup infusion pump in case your pump stops working during administration. Don't lower your dose or stop taking the medication without talking to your provider first, so they can instruct you how to do this safely.

Liver or kidney problems

  • Risk factors: History of liver or kidney problems

Having liver or kidney problems can raise the levels of treprostinil (Remodulin) in your body. This can lead to more unwanted side effects. Let your healthcare provider know if you have a history of liver or kidney problems before you start treprostinil (Remodulin), so they can prescribe you a safe dose.

Low blood pressure

Treprostinil (Remodulin) can cause your blood pressure to drop, because the medication widens your blood vessels. Let your provider know if you feel dizzy or lightheaded while taking the medication.

Interactions between treprostinil (Remodulin) and other medications

Treprostinil (Remodulin) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with treprostinil (Remodulin). Please note that only the generic name of each medication is listed below.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Defibrotide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

What are alternatives to treprostinil (Remodulin)?

There are a number of medications that your doctor can prescribe in place of treprostinil (Remodulin). Compare a few possible alternatives below.

Treprostinil (Remodulin)
Drug Class:Prostacyclin


lowest GoodRx price

View Prices
Ventavis (iloprost)
Drug Class:Prostacyclin


lowest GoodRx price

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Adcirca (tadalafil)
Drug Class:PDE-5 inhibitor


lowest GoodRx price

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