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Opill

Opill Side Effects

Kristianne Hannemann, PharmDAllison Gourley, PharmD
Reviewed by Kristianne Hannemann, PharmD, Allison Gourley, PharmD
Last reviewed on February 5, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

The following side effects were reported in at least 5% of people:

  • Changes in menstrual periods
  • Headache
  • Dizziness
  • Nausea
  • Larger appetite
  • Stomach pain or cramps
  • Bloating
  • Feeling tired
  • Vaginal discharge
  • Nervousness
  • Backache
  • Breast discomfort
  • Acne

Less Common Side Effects

  • Ectopic pregnancy
  • Ovarian cysts
  • Liver problems

Opill serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Possible ectopic pregnancy: stomach pain, spotting
  • Liver problems: yellowing of the skin or whites of the eyes, stomach pain, dark-colored urine, clay-colored stool, fever, tiredness, loss of appetite

Source: DailyMed

The following Opill side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
  • Gallbladder problems—severe stomach pain, nausea, vomiting, fever
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • New or worsening migraines or headaches
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
  • Unusual vaginal discharge, itching, or odor
  • Worsening mood, feelings of depression

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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