olmesartan / amlodipine / HCTZ
Tribenzor is a combination blood pressure medication containing three active ingredients: olmesartan (an angiotensin II receptor blocker (ARB)), amlodipine (a calcium channel blocker), and hydrochlorothiazide (a diuretic (water pill)). It's used to treat high blood pressure in adults who've already taken blood pressure medication before. As a tablet that's taken by mouth once a day, the dosage depends on your previous treatments. The medication is available as brand name and generic versions. Common side effects include dizziness and swelling in arms and legs.
What is Tribenzor?
What is Tribenzor used for?
- High blood pressure in adults
How Tribenzor works
Tribenzor is a combination of three medications that work together to lower blood pressure.
- Olmesartan is an angiotensin II receptor blocker (ARB). It lowers blood pressure by blocking angiotensin II. This is a hormone that typically causes your blood vessels to become more narrow, which raises your blood pressure.
- Amlodipine is a calcium channel blocker (CCB). It relaxes your blood vessels to lower your blood pressure.
- Hydrochlorothiazide is a thiazide diuretic (water pill). It works in your kidneys to remove extra water and certain electrolytes, like sodium and potassium, from your body. This reduces the fluid in your blood vessels, helping to lower blood pressure.
Drug facts
Side effects of Tribenzor
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Dizziness (up to 9%)
- Swelling of legs or arms (8%)
- Headache (6%)
- Tiredness (4%)
- Common cold symptoms (4%)
Less Common Side Effects
- Muscle spasms
- Nausea
- Upper respiratory tract infection
- Diarrhea
- Urinary tract infection
- Joint swelling
Tribenzor serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint or fainting
- Heart attack: cold and clammy skin; sweating; dizziness; tightness or pain in the chest, neck, arms, or back
- Kidney problems: feeling confused; feeling very tired; having trouble thinking clearly; nausea; vomiting; urinating less than usual; swelling in your feet, ankles, or hands
- Abnormal electrolyte levels: nausea, vomiting, constipation, stomach pain, tingling sensation, muscle weakness, muscle cramps, low energy, fluttering heartbeat
- Vision problems: vision changes, eye pain
- Severe diarrhea: having watery bowel movements 10-20 times a day, nausea, weight loss
- Severe allergic reaction: rash, trouble breathing, swelling of the face, lips, throat
The following Tribenzor side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Bloating or swelling of the face, arms, hands, lower legs, or feet
rapid weight gain
tingling of the hands or feet
unusual weight gain or loss
Less common
Bladder pain
bloody or cloudy urine
body aches or pain
difficult, burning, or painful urination
difficulty with breathing
fainting
frequent urge to urinate
headache
loss of voice
lower back or side pain
swelling of the joints
unusual tiredness or weakness
Incidence not known
Persistent non-healing sore
pink growth
reddish patch or irritated area
shiny bump
white, yellow or waxy scar-like area
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Tribenzor
Pros
- Conveniently combines three medications in a single pill
- Can be taken with or without food
- Taken by mouth once a day
Cons
- Not for people who've never taken blood pressure medications before
- Not safe to take while pregnant or breastfeeding
- Can cause dizziness and swelling
Pharmacist tips for Tribenzor
- Mark your calendar for appointments and blood work while taking Tribenzor. Your care team will order tests like potassium, kidney function, and blood pressure during treatment. They might also change your dose based on the lab results.
- Take Tribenzor with or without food. If it hurts your stomach, taking it with food might help.
- You can take Tribenzor at any time of day. But since it contains hydrochlorothiazide, which can make you urinate more often, you might prefer taking it in the morning or early afternoon to avoid waking up at night. It's best to take Tribenzor at the same time every day.
- It's important to take Tribenzor every day as prescribed. Managing your blood pressure helps prevent severe and life-threatening health problems, such as heart attack, stroke, and heart failure.
- Check your blood pressure regularly at home to track how well Tribenzor is working. Record your readings and share them with your prescriber.
- Don't change your Tribenzor dose or stop it suddenly without talking to your prescriber. Doing so can cause your blood pressure to rise quickly.
- Olmesartan, amlodipine, and hydrochlorothiazide interact with many medications. Make sure to tell your care team about all of the medications you're taking before and during treatment.
- You might feel dizzy when you start taking Tribenzor and when your provider raises your dose. This side effect should lessen over time as you continue taking the medication and your body gets used to your new blood pressure. But if you faint, stop taking this medication and tell your prescriber right away.
- Before going outside, apply sunscreen and wear clothing to protect your skin from the sun. The hydrochlorothiazide in Tribenzor can make your skin more sensitive to sunlight, so it’s important to protect your skin when outdoors.
- Try to limit foods high in potassium and potassium-containing salt substitutes. Eating them with Tribenzor might cause high potassium, which can lead to nausea, vomiting, or muscle weakness.
- Tribenzor can cause severe harm to an unborn baby if taken during pregnancy. Let your care team know if you're pregnant or thinking of becoming pregnant, they might recommend a safer medication.
- It's generally not recommended that you breastfeed during treatment with Tribenzor. Animal studies show that the medication can pass into breast milk, though it's not clear how this might affect the nursing baby. To be safe, speak to your prescriber about alternatives to breastfeeding or safer blood pressure medications you can take during this time.
Common questions about Tribenzor
You might notice your blood pressure begin to drop right after you start taking Tribenzor. But, it takes about 2 weeks to see the full effect. You can track how well Tribenzor is working by checking your blood pressure regularly at home. But it can take some time to find the right dose to control your blood pressure.. So continue taking Tribenzor and follow up with your prescriber regularly.
No, Tribenzor doesn't contain a beta blocker. It contains an angiotensin II receptor blocker (ARB) (olmesartan), calcium channel blocker (amlodipine]), and a diuretic (water pill) (hydrochlorothiazide). All of these classes work to lower blood pressure, but they do so in different ways. Depending on how high your blood pressure is, your cardiologist might consider prescribing a beta blocker for you to take with Tribenzor. Ask your healthcare team if you have more questions on the different types of blood pressure medications.
No, Tribenzor doesn't contain an ACE inhibitor. But it does contain an angiotensin II receptor blocker (ARB) (olmesartan), which is similar to an ACE inhibitor. Both ARBs and ACE inhibitors lower blood pressure by stopping angiotensin II from working. A major difference is ARBs like olmesartan have a lower risk of dry cough. It's typically not recommended to take an ACE inhibitor if you're already taking Tribenzor because this can raise your risk for serious side effects like kidney problems or high blood potassium levels.
It's not entirely clear when the best time of day to take blood pressure medications like Tribenzor. Since it contains the diuretic hydrochlorothiazide, which makes you urinate more, you might want to take it in the morning or early afternoon to avoid waking up at night to use the bathroom. The most important thing is to take Tribenzor consistently at the same time each day. If you're unsure when to take it, speak with your prescriber.
Erectile dysfunction (ED) wasn't a reported side effect from people taking Tribenzor during clinical studies. But, in general, blood pressure medications, especially thiazide diuretics like hydrochlorothiazide, can raise the risk for ED. Talk to your prescriber if you're experiencing symptoms of ED after starting this medication.
It’s best to ask your healthcare team how much alcohol is safe for you, as it depends on your other medications and health conditions. But in general, it's recommended to avoid alcohol while taking blood pressure medications like Tribenzor because it can cause sudden changes in your blood pressure. This can lead to symptoms like dizziness and falls.
Not usually. Tribenzor is typically taken once a day. If one dose doesn’t fully control your blood pressure, your prescriber might raise your dose or add another blood pressure medication.
Yes, Tribenzor is available as a generic.
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Risks and warnings for Tribenzor
Tribenzor can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Low blood pressure
- Risk factors: Not enough fluid in your body | Having diarrhea or vomiting for a long time | Low salt levels in your body | Taking high doses of diuretic medications | History of narrow heart valves (aortic or mitral stenosis)
Sometimes, taking Tribenzor can cause your blood pressure to drop too much, which can make you feel dizzy, tired, or lightheaded. This side effect is more common when you first start this medication or when the dose is raised. It also might be more likely to happen if you're dehydrated or if you're taking a high dose of a diuretic. Make sure to stay well hydrated to avoid having blood pressure that's too low. Sit down slowly while holding onto something if you feel dizzy from low blood pressure. Let your care team know if your blood pressure drops too much. Get medical help immediately if you fall and hit your head.
Risk of heart attack or chest pain
- Risk factors: Severe coronary artery disease
Although rare, it's possible for some people to have worsening chest pain or a heart attack while taking Tribenzor. The risk is higher when you first start this medication or when your dose is raised. Your risk is also higher if you have a heart condition called coronary artery disease (CAD). Get medical help right away if you have chest pain, pressure in the chest, heartburn, dizziness, or trouble breathing.
Possible kidney damage in certain people
- Risk factors: Heart failure | Certain kidney problems | Taking other medications that can cause kidney damage
Although ARBs like olmesartan in Tribenzor can protect the kidneys, they can sometimes affect kidney function and cause them to not work as well. This can happen to anyone. But the effects can be more serious in people with severe heart failure, people with certain kidney problems, or people who take medications that can worsen kidney function. Let your prescriber know if you're having problems with urination, as this could be a sign that your kidneys aren't working as well.
Changes in electrolyte, blood sugar, and cholesterol levels
- Risk factors: Taking other medications that can change electrolyte, blood sugar, or cholesterol levels
Tribenzor can affect the level of certain electrolytes, including sodium, potassium, and magnesium in your body. It can also change your blood sugar levels and raise the cholesterol and triglycerides levels.
You might need regular blood tests done while taking Tribenzor to check that your electrolyte, blood sugar, and cholesterol levels are normal. Let your care team know about all the medications you're taking because some of them can cause similar changes. Tell your care team if you experience an irregular heartbeat, weakness, low energy, muscle weakness or cramps, reduced urination, nausea, or vomiting. These can be signs of electrolyte imbalances.
Lupus
- Risk factors: History of lupus
Medications containing hydrochlorothiazide like Tribenzor can cause or worsen lupus. Talk to your prescriber if you have symptoms such as feeling very tired, joint pain, or a skin rash across your cheeks and nose.
Vision problems
- Risk factors: Sulfa or penicillin allergies
Although rare, some people experience vision changes or eye pain within hours or weeks of starting taking hydrochlorothiazide, an ingredient in Tribenzor. Tell your prescriber right away about any vision changes and stop taking Tribenzor, as untreated symptoms could lead to permanent vision loss.
Severe diarrhea
Rarely, people who take olmesartan experience serious diarrhea called sprue-like enteropathy. Sometimes, this happens months to years after starting the medication. In severe cases, the diarrhea can lead to weight loss, stomach pain, tiredness, nausea, and vomiting. If you experience severe diarrhea that doesn't seem to get better after a few days after taking Tribenzor, get medical help right away. Make sure to stay hydrated with fluids and electrolytes.
Tribenzor dosage
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 20mg/5mg/12.5mg | 30 tablets | $37.22 | $1.24 |
| 40mg/10mg/12.5mg | 30 tablets | $47.15 | $1.57 |
| 40mg/5mg/12.5mg | 30 tablets | $46.15 | $1.54 |
| 40mg/10mg/25mg | 30 tablets | $47.15 | $1.57 |
| 40mg/5mg/25mg | 30 tablets | $44.88 | $1.50 |
Typical dosage for Tribenzor
- Adults: The typical dose, which depends on your previous blood pressure medication, is taken by mouth once per day. Your prescriber might adjust your dose after 2 weeks. The maximum dose is 40 mg/10 mg/25 mg (olmesartan/amlodipine/hydrochlorothiazide) once per day.
Interactions between Tribenzor and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abametapir
- Aceclofenac
- Acemetacin
- Acetyldigoxin
- Amphetamine
- Amtolmetin Guacil
- Arsenic Trioxide
- Aspirin
- Atazanavir
- Benazepril
- Benzphetamine
- Bromfenac
- Bufexamac
- Captopril
- Celecoxib
- Ceritinib
- Choline Salicylate
- Clarithromycin
- Clonixin
- Clopidogrel
- Conivaptan
- Cyclosporine
- Dantrolene
- Deslanoside
- Desmopressin
- Dexibuprofen
- Dexketoprofen
- Dextroamphetamine
- Diclofenac
- Diflunisal
- Digitalis
- Digitoxin
- Digoxin
- Dipyrone
- Domperidone
- Droperidol
- Droxicam
- Enalapril
- Enalaprilat
- Epirubicin
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fepradinol
- Feprazone
- Flecainide
- Floctafenine
- Flufenamic Acid
- Flurbiprofen
- Fosinopril
- Fosnetupitant
- Ibuprofen
- Indomethacin
- Ketanserin
- Ketoprofen
- Ketorolac
- Lacosamide
- Levomethadyl
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Methamphetamine
- Methotrexate
- Metildigoxin
- Moexipril
- Morniflumate
- Nabumetone
- Naproxen
- Nepafenac
- Netupitant
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Ouabain
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Perindopril
- Phenylbutazone
- Piketoprofen
- Piperaquine
- Piroxicam
- Porfimer
- Proglumetacin
- Propyphenazone
- Proquazone
- Proscillaridin
- Quinapril
- Ramipril
- Rifampin
- Ritonavir
- Rofecoxib
- Salicylic Acid
- Salsalate
- Simvastatin
- Sodium Salicylate
- Sotalol
- Sulindac
- Tacrolimus
- Tegafur
- Telaprevir
- Tenoxicam
- Tiaprofenic Acid
- Tolfenamic Acid
- Tolmetin
- Trandolapril
- Trimethoprim
- Valdecoxib
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aminolevulinic Acid
- Bepridil
- Bromfenac
- Bufexamac
- Carbamazepine
- Celecoxib
- Cholestyramine
- Choline Salicylate
- Clonixin
- Colesevelam
- Dexibuprofen
- Dexketoprofen
- Diclofenac
- Diflunisal
- Dipyrone
- Droxicam
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fepradinol
- Feprazone
- Floctafenine
- Flufenamic Acid
- Flurbiprofen
- Ginkgo
- Gossypol
- Ibuprofen
- Indinavir
- Indomethacin
- Ketoprofen
- Ketorolac
- Licorice
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Morniflumate
- Nabumetone
- Naproxen
- Nepafenac
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Phenylbutazone
- Piketoprofen
- Piroxicam
- Proglumetacin
- Propionic Acid
- Propyphenazone
- Proquazone
- Rifapentine
- Rofecoxib
- Salicylic Acid
- Salsalate
- Sodium Salicylate
- Sulindac
- Tenoxicam
- Tiaprofenic Acid
- Tolfenamic Acid
- Tolmetin
- Topiramate
- Valdecoxib
How much does Tribenzor cost?
Tribenzor contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Tribenzor will not be safe for you to take.
- Unable to urinate
- Taking at the same time as aliskiren (Tekturna) in people with diabetes
What are alternatives to Tribenzor?
Tribenzor images
