Nereus
Nereus (tradipitant) is a neurokinin 1 (NK1) receptor antagonist used to prevent vomiting caused by motion sickness. It's FDA approved only for adults. Nereus (tradipitant) comes as an 85 mg capsule that you swallow by mouth. You take 1 or 2 capsules as a single dose on an empty stomach about 60 minutes before an activity that might cause motion sickness. Common side effects are sleepiness, headache, and tiredness. Nereus (tradipitant) is available by prescription only.
What is Nereus (tradipitant)?
What is Nereus (tradipitant) used for?
- Preventing vomiting from motion sickness in adults
How Nereus (tradipitant) works
Nereus (tradipitant) is an NK1 receptor antagonist. It blocks proteins called NK1 receptors, which are part of a pathway in the brain that causes vomiting. Blocking this signaling pathway can help prevent vomiting before it starts.
Drug facts
| Common Brands | Nereus |
|---|---|
| Drug Class | NK-1 receptor antagonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Nereus (tradipitant)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sleepiness (up to 12%)
- Headache (up to 10%)
- Feeling tired (up to 8%)
Nereus (tradipitant) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe sleepiness or tiredness: can't stay awake, confusion, trouble walking safely, trouble staying alert
The following Nereus (tradipitant) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Drowsiness
- Fatigue
- Headache
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Pros and cons of Nereus (tradipitant)
Pros
- Can help prevent vomiting from motion sickness
- Taken as a single dose before you expect motion sickness
- Works differently from common motion sickness medications
Cons
- Must take on an empty stomach
- Can cause sleepiness, headache, and tiredness
- Not approved for children
Pharmacist tips for Nereus (tradipitant)
- Take Nereus (tradipitant) about 60 minutes before an activity that might cause vomiting from motion sickness. This can include riding as a passenger in a car, flying on a plane, or riding a roller coaster. Taking the medication before the motion starts gives it time to work before you feel sick.
- Take Nereus (tradipitant) on an empty stomach. Take it at least 1 hour before or 2 hours after a full meal. This helps the medication work as expected.
- Swallow Nereus (tradipitant) whole with water. Don't open or chew the capsule.
- Don't take more than one dose of Nereus (tradipitant) in 24 hours. Taking more than directed might raise your risk of side effects, like sleepiness and tiredness.
- Don't drive or use machinery after taking Nereus (tradipitant) until you know how it affects you. The medication can cause sleepiness or tiredness. This can make it hard to stay alert and do these activities safely.
- Tell your prescriber and pharmacist about all the medications you take. Some medications can raise your risk of side effects like sleepiness when taken with Nereus (tradipitant). Examples include clarithromycin, itraconazole (Sporanox), and medications that make you tired. Your care team can check that your medications are safe to take together.
- If you're pregnant or planning to become pregnant: Talk to your prescriber about the risks and benefits of taking Nereus (tradipitant). There isn't enough information to know how the medication might affect pregnancy or an unborn baby. Your prescriber can help you choose a safe option for you.
- If you're planning to breastfeed: Tell your prescriber. It isn't known if Nereus (tradipitant) passes into breast milk or how it might affect a breastfed baby. Your prescriber can discuss risks and benefits. If you breastfeed while taking this medication, watch your baby for unusual sleepiness.
- Store Nereus (tradipitant) at room temperature. Protect the capsules from light and moisture.
Risks and warnings for Nereus (tradipitant)
Nereus (tradipitant) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Sleepiness and trouble staying alert
- Risk factors: Taking other medications that cause sleepiness | Taking certain medications that interact with Nereus (tradipitant)
Nereus (tradipitant) can make you sleepy or tired. It can make it harder to focus, think, and react quickly. This can affect your ability to drive or use heavy machinery.
The risk can be higher if you take Nereus (tradipitant) with medications that make you sleepy, like benzodiazepines. Other medications can raise Nereus (tradipitant) levels in your body and increase the risk of side effects. Examples include antibiotics like clarithromycin and antifungals like itraconazole (Sporanox).
Don't drive, use heavy machinery, or do anything that requires your full attention until you know how Nereus (tradipitant) affects you. Get medical help right away if you feel extremely sleepy, can't stay awake, or can't walk safely.
Nereus (tradipitant) dosage
Capsule| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 85mg | 10 capsules | $2,454.25 | $245.43 |
Typical dosage for Nereus (tradipitant)
The typical dose is either 1 capsule (85 mg) or 2 capsules (170 mg). Take the dose by mouth on an empty stomach. Take it about 60 minutes before an activity that can cause vomiting from motion sickness.
How much does Nereus (tradipitant) cost?
$2,454.25
What are alternatives to Nereus (tradipitant)?
Nereus (tradipitant) images
