Key takeaways:
Neffy (epinephrine) is a nasal spray used for the emergency treatment of severe Type 1 allergic reactions, including anaphylaxis. It’s available as a brand-name medication.
The average retail cost for 1 carton of neffy 2 mg is $911.27. And the average retail price of 1 carton of neffy 1 mg is $911.13.
How much you pay for neffy may depend on your location, insurance coverage, and discount eligibility.
GoodRx could help you access neffy at an exclusive cash price. You could also save money by using a manufacturer copay saving card or applying for a patient assistance program.
Save on related medications
Neffy (epinephrine) is a prescription-only medication used for the emergency treatment of severe Type 1 allergic reactions, including anaphylaxis. Epinephrine has traditionally been administered at home via autoinjectors such as EpiPens. But neffy is a nasal spray.
It’s recommended for people at risk for severe allergic reactions to always have access to two doses of epinephrine. (Sometimes, a repeat dose is necessary.) And children who are at risk for these reactions are often required to bring epinephrine with them to school. So it’s no surprise that cost is an important factor when it comes to making sure you or your child always has neffy on hand.
Without insurance, neffy can cost over $900 for a package containing 2 nasal sprays. How much you pay can depend on the pharmacy you use and whether you qualify for any discounts or savings programs. Accessing an exclusive discount through GoodRx or manufacturer savings options may help you pay less.
Search and compare options
How much does neffy cost without insurance?
Without insurance, the average retail cost of 1 carton of neffy 2 mg is $911.27. And the average retail price of 1 carton of neffy 1 mg is $911.13.
Neffy is FDA approved for adults and children who weigh at least 33 lbs (15 kg). It’s available in two doses: 1 mg and 2 mg. The 1 mg dose is for people who weigh 33 lbs to less than 66 lbs. The 2 mg dose is for people who weigh at least 66 lbs (30 kg). Each carton of neffy contains 2 single-use nasal sprays.
The table below shows average cash prices for different quantities of the 1 mg and 2 mg doses of neffy.
What factors affect the cost of neffy?
The cost of neffy can vary based on several factors.
Brand-name vs. generic availability
Generic medications often cost less than their brand-name counterparts. So opting for a generic when one is available is one of the best ways to save on medication.
Neffy doesn’t have a generic version available. This contributes to its higher retail cost. Should a generic become available, the cost of neffy would likely go down.
Dose and quantity
The 1 mg and 2 mg doses of neffy can differ slightly in price, which could affect your total costs. Body weight determines which dose a person is prescribed. So if you’re filling a prescription for a child, the price you pay could also change over time.
If you need to purchase more than 1 carton of neffy at a time, that will also affect how much you pay.
Location
Where you live can affect how much you pay for neffy. GoodRx research found that prescription medication prices vary across U.S. cities. For instance, people living in Denver tend to pay less overall for prescription medications than people living in New Orleans.
Pharmacy
Pharmacies negotiate their own prices for prescription medications. As a result, the cash price for neffy can vary among pharmacies, even ones in the same area. GoodRx can help you compare prices at pharmacies near you.
If one pharmacy offers a lower price than others, you can ask your prescriber to send your prescription there. If your prescription is already at a pharmacy and you want to use a different one, you can ask the new location to initiate a transfer.
Insurance coverage
Insurance may reduce your out-of-pocket costs for neffy, but you may still have copays or coinsurance, as well as a deductible. Your plan may also have neffy placed in a higher copay tier on its formulary (list of covered medications) because it’s a brand-name medication.
Check your plan’s formulary, review your summary of benefits and coverage, or call the number on your prescription insurance card to find out if neffy is covered.
What to do if neffy isn’t covered by your insurance
If your insurance doesn’t cover neffy, here are some options to consider:
See if you qualify for neffy’s copay savings card or patient assistance program.
Access an exclusive discount on neffy through GoodRx. (See below for more information.)
Ask your insurance company to make a formulary exception and cover neffy. If your request is denied, you have the right to file an appeal to challenge the decision.
During the next open enrollment period, compare plans to see if there’s one that offers better coverage for neffy.
Ask your prescriber about neffy alternatives
If you’re seeking a neffy alternative to help you save money, your prescriber can help you determine the best options. Some alternative epinephrine products to consider include:
EpiPen or EpiPen Jr
Your healthcare professional must write you a new prescription if you decide to go with an alternative. And you’ll need to check with your insurance provider about whether the product is covered.
Ways to save on neffy
If you’re looking for ways to save on neffy, here are five options to consider.
1. Use a GoodRx coupon
A GoodRx coupon could help you save on neffy without insurance. Anyone with a valid prescription, regardless of insurance status, can purchase neffy at an exclusive cash price through GoodRx.
Here’s how to save with a coupon:
Go to www.goodrx.com or open the GoodRx app on your mobile device.
Type “neffy” in the search bar.
Click “Start saving,” or tap or click return.
Select the correct dose and quantity, along with your location.
Choose to get your coupon by text or email, or print it out.
If possible, show the coupon to your pharmacy staff before they fill your prescription to avoid delays in processing.
Keep in mind: GoodRx savings may vary by pharmacy and geographic location. The GoodRx website and app can help you compare prices in your area.
2. See if you qualify for a manufacturer copay savings card
If you have commercial insurance, you may be eligible to save with a manufacturer copay savings card. If you qualify, you could pay as little as $0 for your neffy prescription. The card offers a maximum savings of $200 per prescription.
If you’re uninsured, have a high-deductible health insurance plan, or have a plan that doesn’t cover neffy, you may still be able to use the copay savings card. If so, you shouldn’t have to pay more than $199 per prescription.
To qualify for the copay savings card, you must:
Not be enrolled in a government-funded insurance plan, such as a Medicare or Medicaid plan
Fill your neffy prescription in the U.S.
You don’t need to download and show the copay savings card at the pharmacy. Your pharmacist should be able to automatically apply the savings when they process your prescription. If you have questions, call 1-877-696-3339.
3. Check if you’re eligible for a patient assistance program
If you’re uninsured or underinsured, you may be able to access neffy for free through the manufacturer’s patient assistance program.
To be eligible for the neffy patient assistance program, you must:
Meet certain financial requirements and be able to submit proof of income
Be uninsured or have an insurance plan that doesn’t cover neffy
Have a prescription for neffy from a U.S.-licensed healthcare professional
Be a resident of the U.S., Puerto Rico, or the U.S. Virgin Islands
You can download an application form online. Your prescriber will need to complete parts of the form, so you should also talk to them.
If you have questions about the application or the program, call 1-877-207-9529 for help.
4. See if you qualify for Medicare Extra Help
The Medicare Extra Help program helps reduce Medicare Part D costs for certain people with limited income. If you qualify, you will have no monthly premiums, no annual deductible, and low copays.
You can apply online for Medicare Extra Help. You can also call 1-800-772-1213 (or 1-800-325-0778 for TTY users) to apply over the phone.
5. Tap into your HSA, FSA, or HRA
Consider using a health savings account (HSA), a flexible spending account (FSA), or a health reimbursement arrangement (HRA) to buy neffy. These accounts let you use pretax dollars to cover copays, coinsurance payments, and other qualified medical expenses. This can help you reduce your spending through tax savings.
Just be sure to review your account’s rules regarding expiration dates. FSA dollars typically expire at the end of the plan year. But HSA funds roll over and can be saved for later. HRA dollars may or may not expire, depending on your account.
The bottom line
Neffy (epinephrine) is a brand-name nasal spray used for the emergency treatment of severe Type 1 allergic reactions, including anaphylaxis. The average retail cost for 1 carton of neffy 2 mg is $911.27. And the average retail price of 1 carton of neffy 1 mg is $911.13. How much you pay may depend on your location, insurance coverage, and discount eligibility.
There are ways to save on neffy. For instance, GoodRx could help you access neffy at an exclusive cash price. Using a manufacturer copay card or enrolling in a patient assistance program could also help you save money.
Why trust our experts?
References
Amneal Pharmaceuticals of New York. (2026). Epinephrine injection [package insert]. DailyMed.
ARS Pharmaceuticals Operations. (2026). Neffy - epinephrine spray [package insert]. DailyMed.
Neffy. (2025). Savings and support. ARS Pharmaceuticals Operations.
Neffy. (2026). ARS patient assistance program application. ARS Pharmaceuticals Operations.
