Neffy Dosages: Your GoodRx Guide

Neffy (epinephrine) is a prescription medication that’s used to treat Type 1 allergic reactions, including anaphylaxis. It’s the first FDA-approved epinephrine nasal spray.

Neffy comes as a pack that contains 2 single-dose nasal sprays. Each nasal spray contains 1 dose of epinephrine. Neffy is available in 1 mg and 2 mg doses. The dose you use is based on your body weight.

Understanding the correct neffy dosage for you can help you be prepared for an allergic emergency. Here, we’ll discuss typical neffy dosages for adults and children and how to use neffy.

What’s the typical neffy dosage for adults?

The typical neffy dosage for most adults is 2 mg (the contents of one device) sprayed into one nostril.

You should use a dose at the first sign of a severe allergic reaction. Symptoms of a severe allergic reaction include tightness of the throat and trouble breathing. You may also notice swelling of the face, tongue, or throat.

Neffy dosages are based on your body weight. You must weigh at least 66 lbs (30 kg) to use the 2 mg dose of neffy. Most adults meet this weight requirement. But if you weigh from 33 lbs (15 kg) to less than 66 lbs, you should use the 1 mg dose of neffy. After using a dose, make sure to call 911 or seek emergency help.

Neffy comes in a pack that has 2 single-dose nasal sprays. This is because you may need a second dose if your symptoms don’t improve or they return. You should wait at least 5 minutes before using a second dose. And make sure to spray it into the same nostril as the first dose.

How to use neffy

Use neffy as soon as you notice symptoms of a severe allergic reaction. To use neffy, follow these simple steps:

1. Remove neffy from its packaging.

2. Insert the tip of the nasal spray fully into the left or right nostril until your fingers touch your nose. Support the bottom of the nasal spray using your thumb.

3. Hold the nasal spray straight into the nose. Don’t aim neffy toward the inner or outer wall of your nostril.

4. Press the plunger firmly to administer the dose. Avoid sniffing during and after the dose is administered. Remove the nozzle from your nose.

5. Call 911 or head to the nearest ER. A severe allergic reaction often needs monitoring or emergency medical care, even after you use epinephrine.

6. If your symptoms don’t improve or they return, use a second dose of neffy. Make sure to wait at least 5 minutes between doses, and use it in the same nostril as the first dose.

Each neffy nasal spray is for one-time use only, so don’t test or prime the nasal spray. Doing so will waste the dose.

What’s the typical neffy dosage for children?

The neffy dosage for children ages 4 and older who weigh at least 66 lbs is the same as the dosage for adults. You should administer 1 spray of neffy 2 mg into one nostril as soon as they have symptoms of a severe allergic reaction. If your child weighs from 33 lbs to less than 66 lbs, you should administer 1 spray of neffy 1 mg into one nostril.

If your child is under age 4 or weighs less than 33 lbs, they shouldn’t use neffy. Talk to a healthcare professional about other treatment options. They might recommend Auvi-Q (epinephrine), which is an epinephrine product that’s FDA approved for people of all ages who weigh at least 16.5 lbs (7.5 kg).

Call 911 or seek emergency care after using a dose of neffy. If a second dose is needed, wait at least 5 minutes and administer the dose into the same nostril.

Are there any dosage adjustments for health conditions?

No, neffy doesn’t have any recommended dosage adjustments for health conditions.

Neffy may not work as well in people with certain nasal conditions, though. This may include nasal polyps, a history of nasal fracture or injury, and a history of nasal surgery. These conditions can affect how well your body absorbs neffy.

Talk to a healthcare professional if you have one of these conditions. Another form of epinephrine, such as an EpiPen, may be a better option for you.

Some health conditions may raise your risk of side effects from neffy. These include:

• Heart disease

• High blood pressure

• Irregular heart rate

• Diabetes

• Overactive thyroid

• Parkinson’s disease

• Kidney problems

Older adults and pregnant women may also have a higher risk of side effects. But even with these conditions, epinephrine is still the preferred treatment for serious allergic reactions. The benefits of the medication typically outweigh the potential risks.

Be sure to talk to a healthcare professional about your health history before using neffy. They can help you understand how to use neffy safely and what to expect.

Neffy contains sulfites, which are ingredients that can cause allergic reactions in some people. This is different from a sulfa allergy. But if you’re having a severe allergic reaction and you also have a sulfite allergy, you should still use neffy. Neffy is a life-saving medication. Delaying treatment could be more dangerous than the risk of a reaction to the sulfites it contains.

What should you do if you use too much neffy?

Always follow your prescriber’s instructions and use neffy exactly as directed. Using more doses than recommended can raise your risk of side effects.

Most side effects are mild and go away quickly, within about 30 minutes after administering a dose. Common side effects include nasal discomfort, throat irritation, and headaches. Serious side effects, such as raised blood pressure and heart rhythm changes, are less common but also possible.

If you think you’ve used too much neffy, contact a healthcare professional or go to the nearest ER right away. They can monitor you and provide treatment if needed. You can also call Poison Control at 1-800-222-1222 for guidance.

How to save on neffy

There are ways to save on neffy, which is available as a brand-name medication:

• Save with Goodrx. Using a free Goodrx coupon, you may be able to purchase neffy at an exclusive cash price.

• Save with a copay savings card. If you have commercial insurance, you may be eligible to pay as little as $0 using a copay savings card from the manufacturer. 

• Save with patient assistance programs. If you’re uninsured or underinsured, you may be eligible for neffy’s patient assistance program, which offers neffy at no cost. 

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Written by:

Arnisha Carter, PharmD, BCPS

Arnisha Carter, PharmD, BCPS, is a licensed pharmacist in Florida. She’s worked in the pharmacy industry for more than 10 years and began writing for GoodRx in 2024.

Edited by:

Christina Aungst, PharmD, MWC

Christina Aungst, PharmD, MWC is a senior pharmacy editor for GoodRx. She began writing for GoodRx Health in 2019.

Reviewed by:

Alyssa Billingsley, PharmD

Alyssa Billingsley, PharmD, is the director of pharmacy content for GoodRx. She has over a decade of experience as a pharmacist and has worked in clinical, academic, and administrative roles.

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