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Neffy Coupon - Neffy 2 nasal sprays of 2mg/0.1ml carton

Neffy

epinephrine
Used for Anaphylaxis
Used for Anaphylaxis

Neffy (epinephrine) is the first nasal spray used to treat severe allergic reactions, including anaphylaxis. It's approved for adults and children who are ages 4 and older who weigh at least 33 lbs. It's given as one spray into one nostril, and a second dose can be given in the same nostril 5 minutes later if needed. Each nasal spray only contains one ready-to-use dose. Potential side effects include nasal discomfort, throat irritation, and headache.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on March 13, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesReferencesPricesMedicare
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What is Neffy (epinephrine)?

What is Neffy (epinephrine) used for?

How Neffy (epinephrine) works

Neffy (epinephrine) is a non-selective alpha- and beta-adrenergic receptor agonist that acts on receptors (signaling proteins) throughout the body. In doing so, it keeps your blood pressure from dropping too low, raises your heart rate, and opens your lungs so you can breathe normally. It also helps with swelling, itching, rashes, hives, and stomach issues linked to an allergic reaction.

Are you looking for information on epinephrine (Epipen) or Auvi-Q (epinephrine) instead?

Drug Facts

Common BrandsNeffy
Drug ClassAdrenergic receptor agonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Neffy (epinephrine) essentials

Neffy product in hand on blue background Courtesy ARS Pharma 2400

5 Things to Know About Neffy, the First FDA-Approved Epinephrine Nasal Spray

Written by Christina Aungst, PharmD
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What are the side effects of Neffy (epinephrine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Adults:
  • Throat irritation (up to 19%)
  • Headache (up to 18%)
  • Nasal discomfort (up to 13%)
  • Feeling jittery (up to 11%)
  • Tremor (up to 8%)
  • Runny nose (up to 7%)
Children:
  • Nasal discomfort (19%)
  • Numbness inside the nose (19%)
  • Runny nose (19%)
  • Nasal congestion (19%)
  • Sneezing (14%)
  • Upper respiratory tract congestion (14%)

Other Side Effects

Adults:
  • Itchy nose
  • Sneezing
  • Stomach pain
  • Gum pain
  • Mouth numbness
  • Stuffy nose
  • Dizziness
  • Nausea
  • Vomiting
Children:
  • Nosebleed
  • Nasal pain
  • Tiredness
  • Feeling jittery
  • Dry throat
  • Nasal dryness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Irregular heart rhythm (arrhythmias): fatigue, weakness, dizziness, shortness of breath, chest pain, sweating
  • High blood pressure: headache, chest pain, dizziness, blurry vision

Source: Prescribing Information

More on Neffy (epinephrine) side effects

neffy: side effects neffy

8 Neffy (Epinephrine) Side Effects and How to Manage Them

Written by Jennifer Gershman, PharmD, CPh, PACS

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Anxiety, nervousness
  • Burning or tingling of the tongue, mouth, throat, or face
  • Headache
  • Irritation inside the nose or throat
  • Runny or stuffy nose
  • Sneezing
pros-and-cons

Pros and cons of Neffy (epinephrine)

thumbs-up

Pros

Good option for people who don't like using needles

Comes in a single-dose spray that's ready to use

Fits in your pocket or purse

thumbs-down

Cons

Might need to use a second dose

Common side effects include nasal discomfort and headache

Might not be the best option for people with certain nose conditions

pharmacist-tips

Pharmacist tips for Neffy (epinephrine)

pharmacist

  • Make sure to carry two Neffy (epinephrine) sprays with you at all times just in case you have an allergic reaction. Having two nasal spray bottles is important in case you need to give another dose.

    • Neffy (epinephrine) can affect the lining of your nose for up to 2 weeks, which can change how your body absorbs nasal sprays. This could lead to more side effects, so check with your prescriber before using other nasal sprays.

      • If your symptoms don't improve or worsen after the first dose of Neffy (epinephrine), you can take another dose by using a new nasal spray in the same nostril, waiting at least 5 minutes after the first dose. Don't give more than two doses without being supervised by a medical professional.

        • Neffy (epinephrine) should only be sprayed into your nose. Avoid spraying it in your eyes or mouth since the medication won't work if used that way.

          • Store Neffy (epinephrine) at room temperature, and avoid leaving it in places where the temperature can get too high or too low (e.g., car glove box).

            How to use Neffy (epinephrine):

            • Make sure you're comfortable with how to use Neffy (epinephrine) properly. Watch these training videos and contact your care team if you have any questions.

              • Each Neffy (epinephrine) carton comes with two single-dose nasal sprays that are meant for one time use. Don't try to reuse the nasal spray after it's used, as there won't be enough medication left to treat your allergic reaction.

                • Don't test or prime Neffy (epinephrine) nasal spray. The dose is ready to use, and spraying it beforehand will waste it.

                  • Use your right hand to spray Neffy (epinephrine) in the right nostril, or your left hand to spray it in your left nostril.

                    • Avoid sniffing during and after spraying a dose of Neffy (epinephrine) in your nose, as this can cause less of the medication to get absorbed.

                      • If you notice dripping from your nose after giving Neffy (epinephrine), it could mean you won't get the full dose. Be prepared to give a second dose after 5 minutes if your symptoms aren't improving or are getting worse.

                        More on Neffy (epinephrine) tips

                        Pharmacy: pharmacy tips neffy

                        How to Administer Neffy — Plus 5 Other Tips to Maximize This Emergency Allergy Treatment

                        Written by Taylor K. Clarke, PharmD
                        Pharmacy: drug interaction neffy

                        8 Neffy (Epinephrine) Interactions and How to Manage Them

                        Written by Sonja Jacobsen, PharmD, BCPS, BCOP
                        faqs

                        Frequently asked questions about Neffy (epinephrine)

                        How fast does Neffy (epinephrine) work?
                        Studies show that Neffy (epinephrine) works as early as 1 minute. In a small study of children with severe food allergies, Neffy (epinephrine) worked within 16 minutes for half of the children after one dose. For the other half, it took longer than 16 minutes. The response time ranged from 1 minute to 90 minutes. Keep in mind that everyone responds differently to medications, so it's important to call 911 in addition to using this medication if you're having a severe allergic reaction.
                        How well does Neffy (epinephrine) work?
                        Clinical studies have shown that Neffy (epinephrine) works just as well or better than the injection version of epinephrine to raise blood pressure and heart rate, which is important when treating severe allergic reactions. In addition, the amount of epinephrine in the blood after giving Neffy (epinephrine) was similar to those measured after giving an injectable form of epinephrine.
                        Is Neffy (epinephrine) over the counter?
                        No, Neffy (epinephrine) isn't sold over the counter. You'll need to get a prescription from a healthcare professional to use it.
                        How many doses are in each Neffy (epinephrine) nasal spray?
                        Each Neffy (epinephrine) nasal spray contains only one dose, and is only meant to be used one time. After using Neffy (epinephrine), throw it away. If you need to use a second dose, use a new nasal spray.
                        Does Neffy (epinephrine) expire?
                        Yes. Make sure to check the expiration date on Neffy (epinephrine) and get a replacement before it expires. If you use it after the expiration date, it might not work well to treat your allergic reaction. This can delay your treatment, which can be life-threatening.
                        Does Neffy (epinephrine) need to be refrigerated?
                        No. Keep Neffy (epinephrine) at room temperature. Don't freeze it because this will cause the medication to not spray out. It's okay if you accidentally leave Neffy (epinephrine) at high temperatures (up to 122°F) for a bit, but tell your prescriber if it's been longer.
                        What's the difference between Neffy (epinephrine) and epinephrine (EpiPen)?
                        Both Neffy (epinephrine) and epinephrine (EpiPen) work within minutes to treat emergency allergic reactions. But Neffy (epinephrine) comes as a single-dose nasal spray, while epinephrine (EpiPen) comes as prefilled syringes and single-dose auto-injectors that are injected into the thigh. Talk to your healthcare professional about additional differences between these medications.
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                        What are the risks and warnings for Neffy (epinephrine)?

                        Neffy (epinephrine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                        risk-warning

                        Absorption problems in certain nasal conditions

                        • Risk factors: History of nasal polyps | History of a broken nose or other nose injury | History of surgery on the nose

                          Neffy (epinephrine) hasn't been studied in people with certain nasal conditions (like nasal polyps) or in people with a history of trauma to the nose. It's unclear how well the medication works in these situations, and it might not be absorbed correctly. Tell your prescriber if you have a history of any nasal conditions other than those due to allergies. They can help you decide whether Neffy (epinephrine) is a good option for you.

                          risk-warning

                          Worsening of certain health problems

                          • Risk factors: Abnormal heart rhythm | High blood pressure | Coronary artery disease | Overactive thyroid | Parkinson’s disease | High blood sugar | Kidney problems

                            Neffy (epinephrine) can make certain health problems worse. Tell your prescriber if you have a history of any of the medical conditions listed above. They'll talk to you about when to use Neffy (epinephrine) and how to handle any worsening of symptoms from other medical conditions.

                            risk-warning

                            Okay to use in people with sulfite allergy

                            Neffy (epinephrine) contains sulfites, which can cause an allergic reaction in some people. But if you're experiencing a severe, life-threatening allergic reaction and have an allergy to sulfites, you should still use Neffy (epinephrine) because it's a life-saving medication.

                            dosage

                            Neffy (epinephrine) dosage forms

                            The average cost for 1 carton of 2 nasal sprays of 2mg/0.1ml of Neffy (epinephrine) is $199.00 with a free GoodRx coupon. This is 77.46% off the average retail price of $882.69.
                            carton
                            Carton
                            DosageQuantityPrice as low asPrice per unit
                            2 nasal sprays of 1mg/0.1ml1 carton$199.00$199.00
                            2 nasal sprays of 2mg/0.1ml1 carton$199.00$199.00

                            Typical dosing for Neffy (epinephrine)

                            Neffy (epinephrine) is available as a carton containing two single-dose nasal sprays. The dose is based on your weight.

                            • 66 lbs or more: The typical dose is 2 mg.

                            • 33 lbs to 66 lbs: The typical dose is 1 mg.

                            Use 1 spray into one nostril when you feel an allergic reaction. Call 911.

                            If your symptoms don't improve or get worse, you can use a new nasal spray to repeat the dose in the same nostril at least 5 minutes after the first dose while waiting for help.

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                            How much does Neffy (epinephrine) cost?

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                            Neffy (brand)
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                            alternatives

                            What are alternatives to Neffy (epinephrine)?

                            There are a number of medications that your doctor can prescribe in place of Neffy (epinephrine). Compare a few possible alternatives below.
                            Neffy (epinephrine)
                            Used for:
                            $199.00 Lowest GoodRx priceView Prices
                            Auvi-Q (epinephrine)
                            Used for:
                            $603.27 Lowest GoodRx priceView Prices
                            Epinephrine (Epipen)
                            Used for:
                            $171.26 Lowest GoodRx priceView Prices
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                            Neffy (epinephrine) images

                            brown and pink - Neffy 2mg Nasal Spray
                            This medicine is Brown And Pink Carton.brown and pink - Neffy 2mg Nasal Spray

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                            References

                            Best studies we found

                            ARS Pharmaceuticals Operations, Inc. (2024). How to use neffy.

                            ARS Pharmaceuticals Operations, Inc. (2025). Neffy® (epinephrine nasal spray) [package insert]. 

                            Dalal, R., et al. (2023). Epinephrine. StatPearls.

                            View All References (2)

                            Ebisawa, M., et al. (2024). neffy, epinephrine nasal spray, demonstrates a positive efficacy and safety profile for the treatment of allergic reactions in pediatric patients at-risk of anaphylaxis: Phase 3 study results. The Journal of Allergy and Clinical Immunology.

                            Ellis, A. K., et al. (2024). Development of neffy, an epinephrine nasal spray, for severe allergic reactions. Pharmaceutics.

                            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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