Neffy vs. Epinephrine-epipen for Anaphylaxis: Important Differences and Potential Risks.

Neffy

(epinephrine)

Epinephrine

(Epipen)

Summary for Neffy

Prescription only

Neffy (epinephrine) is the first nasal spray used to treat severe allergic reactions, including anaphylaxis. It's approved for adults and children who weigh at least 33 lbs. It's given as one spray into one nostril, and a second dose can be given in the same nostril 5 minutes later if needed. Each nasal spray only contains one ready-to-use dose. Potential side effects include nasal discomfort, throat irritation, and headache.

Indications for Neffy

Severe allergic reactions (e.g., anaphylaxis)

Pros and Cons for Neffy

Pros

Good option for people who don't like using needles
Comes in a single-dose spray that's ready to use
Fits in your pocket or purse

Cons

Might need to use a second dose
Common side effects include nasal discomfort and headache
Might not be the best option for people with certain nose conditions

Common Side Effects for Neffy

Adults:

Throat irritation (up to 19%)
Headache (up to 18%)
Nasal discomfort (up to 13%)
Feeling jittery (up to 11%)
Tremor (up to 8%)
Runny nose (up to 7%)

Children:

Nasal discomfort (19%)
Numbness inside the nose (19%)
Runny nose (19%)
Nasal congestion (19%)
Sneezing (14%)
Upper respiratory tract congestion (14%)

Warnings for Neffy

Absorption problems in certain nasal conditions
Worsening of certain health problems
Okay to use in people with sulfite allergy

Summary for Epinephrine-epipen

Prescription only

Epinephrine (Epipen), also known as the hormone adrenaline, is a life-saving injectable medication used to ease symptoms of anaphylaxis. It's available as a pre-filled syringe and auto-injector device that you inject into the muscle or under the skin of the middle of the outer thigh. Epinephrine (Epipen) can stabilize your blood pressure and heart rate, as well as ease your breathing. Side effects of this medication include restlessness, high blood pressure, and fast heart rate.

Indications for Epinephrine-epipen

Severe allergic reactions (e.g., anaphylaxis)

Pros and Cons for Epinephrine-epipen

Pros

A life-saving medication for severe allergic reactions and anaphylaxis
Comes as easy-to-use, prefilled auto-injector devices and syringes
Can be injected through clothing, if needed
Can be used in pregnant or breastfeeding females who are experiencing severe allergic reactions

Cons

Must replace it when it expires, even if it isn't used
Must be stored at room temperature, which can be difficult if you keep this medication in your car during hot or cold weather
Can cause heart-related side effects (e.g., chest pain, irregular heartbeat)
Doesn't last very long, so might need to repeat the dose