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Compare Neffy vs. Epinephrine-epipen

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Neffy (epinephrine)
    Epinephrine (Epipen)
  • Neffy (epinephrine)
    Epinephrine (Epipen)

  • Summary of Neffy vs. Epinephrine-epipen

    Summary for Adrenergic receptor agonist
    Prescription only

    Neffy (epinephrine) is the first nasal spray used to treat severe allergic reactions, including anaphylaxis. It's approved for adults and children who are ages 4 and older who weigh at least 33 lbs. It's given as one spray into one nostril, and a second dose can be given in the same nostril 5 minutes later if needed. Each nasal spray only contains one ready-to-use dose. Potential side effects include nasal discomfort, throat irritation, and headache.

    Summary for Adrenergic receptor agonist
    Prescription only

    Epinephrine (Epipen), also known as the hormone adrenaline, is a life-saving injectable medication used to ease symptoms of anaphylaxis. It's available as a pre-filled syringe and auto-injector device that you inject into the muscle or under the skin of the middle of the outer thigh. Epinephrine (Epipen) can stabilize your blood pressure and heart rate, as well as ease your breathing. Side effects of this medication include restlessness, high blood pressure, and fast heart rate.

  • Indications of Neffy vs. Epinephrine-epipen

    Indications for
    •Severe allergic reactions (e.g., anaphylaxis)
    Indications for
    •Severe allergic reactions (e.g., anaphylaxis)

  • Pros and Cons of Neffy vs. Epinephrine-epipen

    Pros and Const for Adrenergic receptor agonist
    Pros
    •Good option for people who don't like using needles
    •Comes in a single-dose spray that's ready to use
    •Fits in your pocket or purse
    Cons
    •Might need to use a second dose
    •Common side effects include nasal discomfort and headache
    •Might not be the best option for people with certain nose conditions
    Pros and Const for Adrenergic receptor agonist
    Pros
    •A life-saving medication for severe allergic reactions and anaphylaxis
    •Comes as easy-to-use, prefilled auto-injector devices and syringes
    •Can be injected through clothing, if needed
    •Can be used in pregnant or breastfeeding females who are experiencing severe allergic reactions
    Cons
    •Must replace it when it expires, even if it isn't used
    •Must be stored at room temperature, which can be difficult if you keep this medication in your car during hot or cold weather
    •Can cause heart-related side effects (e.g., chest pain, irregular heartbeat)
    •Doesn't last very long, so might need to repeat the dose

  • Common Side Effects of Neffy vs. Epinephrine-epipen

    Common Side Effects for

    Adults:

    •Throat irritation (up to 19%)
    •Headache (up to 18%)
    •Nasal discomfort (up to 13%)
    •Feeling jittery (up to 11%)
    •Tremor (up to 8%)
    •Runny nose (up to 7%)

    Children:

    •Nasal discomfort (19%)
    •Numbness inside the nose (19%)
    •Runny nose (19%)
    •Nasal congestion (19%)
    •Sneezing (14%)
    •Upper respiratory tract congestion (14%)
    Common Side Effects for
    •Feeling anxious, nervous, or restless
    •Shaking or tremors
    •Weakness
    •Dizziness
    •Sweating
    •Racing heart

  • Warnings of Neffy vs. Epinephrine-epipen

    Common Side Effects for
    •Absorption problems in certain nasal conditions
    •Worsening of certain health problems
    •Okay to use in people with sulfite allergy
    Common Side Effects for
    •Emergency medical care
    •Injection-related problems
    •Risk of skin infection
    •Okay to use in people with sulfite allergy
    •High blood pressure and heart rate

  • Prices with our coupons for Neffy vs. Epinephrine-epipen

    Learn more about Neffy
    Learn more about Epinephrine

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