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Nebivolol Coupon - Nebivolol 5mg tablet

nebivolol

Generic Bystolic
Used for Hypertension

Nebivolol (Bystolic) is a beta blocker. It's used to treat high blood pressure in adults, but it's not a first-choice medication. Nebivolol (Bystolic) is a tablet and the typical dose is taken by mouth once a day. Some side effects include headache, dizziness, and tiredness. This medication is available as both brand name Bystolic and generic nebivolol.

Reviewed by:Last reviewed on September 21, 2026
basics-icon

What is Nebivolol (Bystolic)?

What is Nebivolol (Bystolic) used for?

How Nebivolol (Bystolic) works

Nebivolol (Bystolic) is a beta blocker. It mainly works by blocking beta receptors found on your heart. This slows your heart rate and helps lower your blood pressure. Nebivolol (Bystolic) also relaxes your blood vessels, which helps lower blood pressure even more.

When does Nebivolol (Bystolic) start working?Time passed since treatment started:
HOURS
DAYS
WEEKS
Full effect
MONTHS

Drug facts

Common BrandsBystolic
Drug ClassBeta blocker
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Side effects of Nebivolol (Bystolic)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (6-9%)
  • Tiredness (2-5%)
  • Dizziness (2-4%)
  • Diarrhea (2-3%)
  • Nausea (1-3%)

Less Common Side Effects

  • Chest pain
  • Stomach pain
  • Swelling in the arm or leg
  • Trouble sleeping
  • Shortness of breath
  • Weakness
  • Tingling sensation
  • Rash

Nebivolol (Bystolic) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Sudden tightening in the lungs (bronchospasm): chest tightness, trouble catching your breath, trouble breathing, wheezing, cough, dizziness, extreme tiredness
When do Nebivolol (Bystolic) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Dizziness
Tiredness

Source: DailyMed

The following Nebivolol (Bystolic) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bloating or swelling of the face, arms, hands, lower legs, or feet

chest pain or discomfort

difficult or labored breathing

lightheadedness, dizziness, or fainting

rapid weight gain

shortness of breath

slow or irregular heartbeat

tightness in the chest

tingling of the hands or feet

unusual tiredness or weakness

unusual weight gain or loss

wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Absence of or decrease in body movement

anxiety

blue lips, fingernails, or skin

blurred vision

chills

cold sweats

coma

confusion

cool, pale skin

cough

decreased urine output

depression

dilated neck veins

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

extreme fatigue

fast heartbeat

headache

increased hunger

increased sweating

increased thirst

irregular, fast or slow, or shallow breathing

loss of appetite

mood changes

muscle pain or cramps

nausea or vomiting

nervousness

nightmares

noisy breathing

numbness in the hands, feet, or lips

seizures

shakiness

slurred speech

troubled breathing

vomiting

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Mild headache

Less common

Diarrhea

rash

sleeplessness

trouble sleeping

unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Avg retail price
$75.21(Save 82.82%)
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$12.92
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Pros and cons of Nebivolol (Bystolic)

Pros

Cons

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Pharmacist tips for Nebivolol (Bystolic)

pharmacist
  • Take nebivolol (Bystolic) at the same time each day. You can take it with or without food. Taking it regularly as prescribed can help keep your blood pressure under control.
  • If you accidentally forget to take your dose of nebivolol (Bystolic), take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and take the usual dose at your next usual time. Don't double up the dose to make up for a missed dose.
  • Your prescriber might recommend that you regularly check your blood pressure and heart rate at home. Keep a record of your readings and share them with your prescriber. This helps track how well nebivolol (Bystolic) is working for you.
  • Nebivolol (Bystolic) can make you feel tired or dizzy, especially when you first start or after your dose goes up. Sit or lie down if you feel dizzy. Avoid driving or doing anything that needs your full attention until you know how this medication affects you. Tell your prescriber if these side effects bother you or don't go away.
  • It's best to avoid alcohol while taking nebivolol (Bystolic). Alcohol can make side effects like dizziness and tiredness worse. Drinking alcohol regularly can also raise your blood pressure and make it harder to control. Tell your prescriber how much alcohol you usually drink. They can give you guidance about drinking alcohol during treatment.
  • Tell your care team about all the medications you take. Some medications can interact with nebivolol (Bystolic). These can include fluoxetine (Prozac), paroxetine (Paxil), other beta blockers, and certain calcium channel blockers. They can raise the risk of side effects, lower blood pressure too much, or affect your heart rhythm. Your care team can check for interactions and make changes if needed.
  • Don't suddenly stop taking nebivolol (Bystolic) without talking to your prescriber. This can cause serious heart problems, especially in people with heart disease. This has included worsening chest pain or even heart attack. Your prescriber will usually lower your dose slowly if you need to stop treatment.
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Risks and warnings for Nebivolol (Bystolic)

Nebivolol (Bystolic) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Risks with stopping nebivolol (Bystolic) suddenly

Don't suddenly stop taking nebivolol (Bystolic) without talking to your prescriber, especially if you have coronary artery disease. Stopping suddenly can cause serious problems. This can include worsening chest pain or abnormal heart rhythm. In some cases, a heart attack has happened.

If you need to stop nebivolol (Bystolic), your prescriber will usually lower your dose slowly over 1 to 2 weeks. They might also tell you to limit physical activity to help reduce stress on your heart. Tell your care team right away if you have new or worsening chest pain while lowering your dose or after stopping nebivolol (Bystolic).

Risk of trouble breathing

  • Risk factors: Asthma | Chronic obstructive pulmonary disease (COPD) | Other lung condition

Beta blockers like nebivolol (Bystolic) are generally not recommended for people with conditions that can cause breathing problems, such as asthma. Beta blockers can block beta receptors in the lungs. This can make it harder to breathe. Nebivolol (Bystolic) mainly affects the heart, so it might have a lower risk of breathing problems than some other beta blockers.

Tell your prescriber if you have asthma or another lung condition before taking nebivolol (Bystolic). They can check that the medication is right for you.

Hiding symptoms of low blood sugar

  • Risk factors: Diabetes | Fasting before surgery | Not eating regularly | Vomiting often

Nebivolol (Bystolic) can make it harder to notice early signs of low blood sugar. It can hide symptoms like a fast heartbeat or tremors. This is especially important if you use insulin or take diabetes medications, like glipizide. These medications can lower your blood sugar.

If you have diabetes, tell your prescriber. They can tell you when and how often to check your blood sugar while taking nebivolol (Bystolic). Checking your blood sugar can help you catch low blood sugar even if you don't notice the usual symptoms. Keep in mind that sweating might still happen even when other symptoms are hidden. Get emergency medical help if you have severe low blood sugar.

Effects on hyperthyroidism

Nebivolol (Bystolic) can hide signs of hyperthyroidism, such as a fast heartbeat. If you have hyperthyroidism, don't suddenly stop taking nebivolol (Bystolic). This can make your thyroid symptoms worse. Rarely, it can cause a serious condition called a thyroid storm. Talk to your prescriber before stopping the medication.

Worsening circulation problems

  • Risk factors: Peripheral vascular disease

Beta blockers like nebivolol (Bystolic) can make symptoms of peripheral vascular disease worse. Tell your prescriber if you have circulation problems before starting nebivolol (Bystolic). Let them know if you notice new or worsening symptoms during treatment.

Effects during anesthesia and surgery

  • Risk factors: Major surgery requiring anesthesia

Before any major surgery, tell your surgery care team that you take nebivolol (Bystolic). This medication can affect how your heart responds to the effects of anesthesia and surgery. Your care team might need to watch your heart rate and blood pressure closely. Don't stop nebivolol (Bystolic) before surgery unless your care team tells you to.

Severe allergic reactions might be harder to treat

  • Risk factors: History of severe allergic reaction

If you've had a severe allergic reaction in the past, tell your prescriber before taking nebivolol (Bystolic). Beta blockers like nebivolol (Bystolic) might make a future allergic reaction more severe. They can also make the usual dose of epinephrine used to treat a severe allergic reaction work less well. Talk to your care team about what to do if you have an allergic reaction.

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Nebivolol (Bystolic) dosage

The average cost for 30 tablets of 5mg of Nebivolol (Bystolic) is $12.92 with a free GoodRx coupon. This is 82.82% off the average retail price of $75.21.
tabletTablet
DosageQuantityPrice as low asPrice per unit
2.5mg90 tablets$26.53$0.29
5mg30 tablets$12.92$0.43
10mg90 tablets$28.73$0.32
20mg90 tablets$31.74$0.35
interactions-icon

Interactions between Nebivolol (Bystolic) and other drugs

Nebivolol (Bystolic) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Nebivolol (Bystolic). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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How much does Nebivolol (Bystolic) cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
contraindications-icon

Nebivolol (Bystolic) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Nebivolol (Bystolic) will not be safe for you to take.

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What are alternatives to Nebivolol (Bystolic)?

There are a number of medications that your doctor can prescribe in place of Nebivolol (Bystolic). Compare a few possible alternatives below.
Nebivolol (Bystolic)
$12.92Lowest GoodRx priceView prices
Used for:
$9.00Lowest GoodRx priceView prices
Used for:
  • High blood pressure
$9.00Lowest GoodRx priceView prices
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News about Nebivolol (Bystolic)

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References

Best studies we found

Acelajado, M. C., et al. (2012). Both morning and evening dosing of nebivolol reduces trough mean blood pressure surge in hypertensive patients. Journal of the American Society of Hypertension.

ANI Pharmaceuticals. (2025). NEBIVOLOL tablet [package insert]. DailyMed.

Fongemie, J., et al. (2015). A review of nebivolol pharmacology and clinical evidence. Drugs.

Gul, F., et al. (2023). Peripheral vascular disease. StatPearls.

MedlinePlus. (2026). Sick sinus syndrome.

MedlinePlus. (2026). Thyroid storm.

Morales, D. R., et al. (2017). Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: Population-based nested case control study. BMC Medicine.

Münzel, T., et al. (2009). Nebivolol: The somewhat-different β-adrenergic receptor blocker. Journal of the American College of Cardiology.

National Heart, Lung, and Blood Institute. (2022). What is cardiogenic shock?

Sharp, R. P., et al. (2017). Nebivolol versus other beta blockers in patients with hypertension and erectile dysfunction. Therapeutic Advances in Urology.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.