Myhibbin
Myhibbin (mycophenolate mofetil) is a ready-to-use liquid suspension that's approved for people ages 3 months and older. It helps prevent the body from rejecting a kidney, heart, or liver transplant. Myhibbin (mycophenolate mofetil) is a type of immunosuppressant medication called an antiproliferative agent; it works by weakening your immune system. Myhibbin (mycophenolate mofetil) is taken twice daily on an empty stomach. This medication has many possible side effects, including diarrhea, nausea, and changes in blood pressure.
What is Myhibbin (mycophenolate mofetil)?
What is Myhibbin (mycophenolate mofetil) used for?
Prevention of kidney, heart, or liver transplant rejection in people ages 3 months and older; taken with other anti-rejection medications
How Myhibbin (mycophenolate mofetil) works
Myhibbin (mycophenolate mofetil) is a type of immunosuppressant called an antiproliferative agent. It weakens your immune system by blocking your body from making certain immune system cells. This helps prevent your body from rejecting a transplanted organ.
Drug Facts
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What are the side effects of Myhibbin (mycophenolate mofetil)?
Common Side Effects
- Muscle, neck, or back pain (79%)
- High blood pressure (79%)
- Swelling (68%)
- Headache (59%)
- Fever (56%)
- Nausea (56%)
- Diarrhea (53%)
- Weakness (49%)
- High blood sugar (48%)
- High cholesterol (46%)
- Shortness of breath (44%)
- Constipation (44%)
- Trouble sleeping (43%)
- Stomach pain (42%)
- Cough (41%)
- Vomiting (39%)
- Dizziness (34%)
- Low blood pressure (34%)
- Low potassium levels (33%)
- Viral infection (31%)
Other Side Effects
- Indigestion
- Depression
- Tremor (shakiness)
- Fast heart rate
- Bruising
- Rash
- Low blood cell counts
- Low magnesium levels
Serious Side Effects
- Serious allergic reaction: trouble breathing; hives; swelling of your face, lips, tongue, or throat
- Serious infection: fever; cough; trouble breathing; diarrhea; weakness; sweating; chills; scaly, itchy, or burning skin; confusion; changes in personality; changes in vision; headache; stiff neck
- Bleeding: blood in your urine or stool, unexplained bruising, bleeding that takes longer than usual to stop
- Stomach bleeding: black, tarry stool; bright red blood in vomit or stool
- Cancer
Source: FDA
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Joint, muscle, or tendon pain, swelling, or stiffness
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Peptic ulcer—burning stomach pain, loss of appetite, bloating, burping, heartburn, nausea, vomiting
- Stomach bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds
- Stomach pain that is severe, does not go away, or gets worse
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Constipation
- Diarrhea
- Headache
- Nausea
- Swelling of the ankles, hands, or feet
- Tremors or shaking
- Trouble sleeping
- Vomiting
Pros and cons of Myhibbin (mycophenolate mofetil)
Pros
Raspberry-flavored liquid suspension
Good option for people who have a hard time swallowing pills
Doesn't contain phenylalanine (artificial sweetener), so it's safe for people with a genetic condition called phenylketonuria (PKU)
Cons
Can have a lot of side effects, such as stomach upset, dizziness, changes in sleep, and low blood cell counts
Not safe to take during pregnancy
No lower-cost generic available; brand name only
Pharmacist tips for Myhibbin (mycophenolate mofetil)
Take Myhibbin (mycophenolate mofetil) twice daily at the same time every day on an empty stomach. Only take the medication with food if your prescriber told you that it's okay. If you do take it with food, make sure to be consistent and always take it with food; this will help keep the levels of the medication steady in your body.
Follow your care team's instructions on how to measure out and take your dose of Myhibbin (mycophenolate mofetil). Don't use household spoons because these might not be accurate and using them can cause you to take the wrong dose. Don't mix Myhibbin (mycophenolate mofetil) with any liquids before you take your dose.
Myhibbin (mycophenolate mofetil) can cause sleepiness, but it can also make you have trouble falling asleep. Pay attention to how this medication affects your sleep. Contact your care team if it's making you too sleepy or if it's interrupting your sleep. Your prescriber might adjust your dose or the timing of your doses to help.
Before you get any vaccines, tell the healthcare professional (HCP) that you're taking Myhibbin (mycophenolate mofetil). Your HCP will check that the vaccine is safe for you to get. Myhibbin (mycophenolate mofetil) can make vaccines work less well to protect you from infection. You can also get sick from live vaccines like Varivax (chickenpox vaccine). It's best to be up to date on all your vaccinations before you start this medication.
If you take magnesium- or aluminum-containing antacids or phosphate binders like sevelamer (Renvela), take them at least 2 hours after Myhibbin (mycophenolate mofetil). This prevents the medications from interfering with each other — these antacids can make the immunosuppressant work less well and put you at risk for transplant rejection.
Make sure you tell your care team and pharmacist about all of the medications you're taking and planning to take. Your care team can check for drug interactions with Myhibbin (mycophenolate mofetil) and make sure your medications are safe to take together. Many medications can make Myhibbin (mycophenolate mofetil) work less well, which can lead to the risk for transplant rejection.
If you miss a dose of Myhibbin (mycophenolate mofetil), take it as soon as you remember unless there's only 2 more hours until your next usual dose. Otherwise, skip the missed dose and take your usual dose at the time you typically take the medication. Talk with your transplant team or pharmacist if you consistently miss doses because this can lead to transplant rejection.
If you or your partner can become pregnant, use birth control during treatment with Myhibbin (mycophenolate mofetil) to prevent pregnancy because of the risk of harm to unborn babies. Continue using birth control for at least 6 weeks (for females) and for at least 3 months (for males) after you take your last dose. Tell your healthcare team right away if you or your partner becomes pregnant.
Don't donate blood for at least 6 weeks after your last dose of Myhibbin (mycophenolate mofetil). Don't donate semen for at least 3 months after the last dose as well. This lowers the risk for harm to babies from the medication if the donated blood or semen happens to be given to someone who could get pregnant.
Be careful not to get Myhibbin (mycophenolate mofetil) on your skin, in your eyes, or in your nose. Wash the area of skin well with soap and water if the medication accidentally gets on your skin. And rinse your eye with plain water if it accidentally gets in your eye.
After you open a bottle of Myhibbin (mycophenolate mofetil), the medication is good for 60 days (2 months). Ask a pharmacist about how to discard the medication after it's been 2 months since you've opened the bottle.
Frequently asked questions about Myhibbin (mycophenolate mofetil)
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What are the risks and warnings for Myhibbin (mycophenolate mofetil)?
Myhibbin (mycophenolate mofetil) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Not safe during pregnancy
Don't take Myhibbin (mycophenolate mofetil) if you're pregnant and if there are safer treatment options available. This medication can raise the risk for miscarriage (pregnancy loss) during the first trimester and birth defects if it's taken during pregnancy.
If you can become pregnant, you'll need to take a pregnancy test before you start Myhibbin (mycophenolate mofetil) and also periodically during treatment. Also use effective birth control during treatment if you're sexually active and you or your partner can become pregnant. Continue using birth control for at least 6 weeks (for females) and for at least 3 months (for males) after you take your last dose. Note that this medication can lower how well levonorgestrel-containing birth control works. Discuss with your transplant team about other treatment options if you're thinking of becoming pregnant.
Possible risk of cancer
Risk factors: Long-term use
People who take immunosuppressants like Myhibbin (mycophenolate mofetil) for a long time might be at higher risk for cancer. These cancers can include lymphomas and skin cancer, among others. Your transplant specialist will check your risk of cancer during treatment. Speak with your transplant team if you're concerned about the risk for cancer with Myhibbin (mycophenolate mofetil).
To lower your risk for skin cancer specifically, wear protective clothing and use sunscreen when you go outside. Also avoid ultraviolet light (e.g., tanning beds). Make sure to check your skin for any unusual changes and tell your care team if you notice anything strange.
Serious infections
Myhibbin (mycophenolate mofetil) can affect your body's ability to fight off infections. This can raise your risk for serious and sometimes life-threatening infections, including those caused by bacteria, fungi, or viruses. For example, some serious viral infections have included progressive multifocal leukoencephalopathy (PML) and COVID-19, among others. In some cases, infections can happen when an inactive germ in your body, like the bacteria that cause tuberculosis (TB) or the hepatitis virus, reactivates and makes you sick again.
Your transplant care team will examine you routinely for infections before you start Myhibbin (mycophenolate mofetil) and during treatment. Let your transplant team know as soon as possible if you notice any signs of infection like fever, chills, body aches, cough, or pain when urinating.
Low blood cell counts
Some people who take Myhibbin (mycophenolate mofetil) can have lower numbers of red blood cells (RBCs), white blood cells (WBCs), and platelets in the body. Low RBCs can put you at risk for anemia, low WBCs for infections, and low platelets for bleeding. Your transplant team will order blood draws during treatment to check your blood cell counts.
Let your transplant team know if you have possible symptoms of anemia, such as tiredness, headache, pale skin, fast heart rate, and trouble breathing. Also contact your care team if you notice you have small, flat red spots under the skin or easy bleeding or bruising. In addition, tell your transplant specialist right away if you have symptoms of an infection, like fever, chills, tiredness, cough, body aches, and runny nose.
Stomach bleeding and ulcers
Risk factors: Age 65 years and older | History of stomach bleeding, ulcers, or other digestive system problem
Some people who took Myhibbin (mycophenolate mofetil) have had serious stomach problems, including bleeding and ulcers (sores). These stomach problems can be dangerous and might require treatment right away. Get medical help right away if you're feeling faint, vomiting blood, have bloody or dark stools, or have severe stomach pain or discomfort that doesn't go away while you're taking Myhibbin (mycophenolate mofetil). These can be signs of a bleed in the digestive tract.
Avoid in people with a genetic condition called hypoxanthine-guanine phosphoribosyl-transferase (HGPRT) deficiency
Avoid taking Myhibbin (mycophenolate mofetil) if you have a genetic condition called hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. This medication can worsen your symptoms, including gout, kidney stones, other kidney problems, or even kidney failure.
Inflammation in the body
Myhibbin (mycophenolate mofetil) weakens the immune system to lower inflammation to help prevent organ rejection. But very rarely, some people have had symptoms of inflammation in the body during treatment. Symptoms can include fever, joint or muscle pain, and changes in certain lab results. These symptoms can happen within weeks to months of starting Myhibbin (mycophenolate mofetil) or after dose changes.
Your transplant team will check for signs and symptoms of inflammation during treatment with Myhibbin (mycophenolate mofetil). Tell your transplant team right away if you have any fever, joint pain, or muscle pain while you're taking this medication.
Must be careful when driving
Risk factors: Drinking alcohol | Taking other medications that can cause sleepiness
Make sure you know how Myhibbin (mycophenolate mofetil) affects you before driving a car or doing activities that require your concentration. Myhibbin (mycophenolate mofetil) can cause sleepiness, dizziness, and confusion. These side effects can lower your ability to think, react, and focus. You're at greater risk for these side effects if you're also taking other medications that can cause drowsiness, such as benzodiazepines and muscle relaxants. Myhibbin (mycophenolate mofetil) can also cause tremors (shakiness), which can make driving harder to do safely. Talk to your care team if you have these side effects while you're taking Myhibbin (mycophenolate mofetil) and if they're not getting better with time.
Myhibbin (mycophenolate mofetil) dosage forms
Typical dosing for Myhibbin (mycophenolate mofetil)
Adults
Kidney transplant: The typical dose is 1,000 mg (or 5 mL of the liquid) by mouth twice a day.
Heart or liver transplant: The typical dose is 1,500 mg (or 7.5 mL of the liquid) by mouth twice a day.
Children ages 3 months and older: The prescriber will calculate the dose based on your child's body size (height and weight). They'll tell you how much your child should take. Typically, Myhibbin (mycophenolate mofetil) is taken by mouth twice a day.
Your prescriber will adjust your dose based on how well the medication is working for you and whether you're having side effects. For people with a kidney transplant, the prescriber will adjust the dose depending on kidney function.
How much does Myhibbin (mycophenolate mofetil) cost?
Myhibbin (mycophenolate mofetil) contraindications
Allergy to mycophenolate mofetil or mycophenolic acid (Myfortic)
Allergy to polysorbate 80, an inactive ingredient in Myhibbin (mycophenolate mofetil)
What are alternatives to Myhibbin (mycophenolate mofetil)?
Prevention of kidney, heart, or liver transplant rejection in people ages 3 months and older; taken with other anti-rejection medications
Prevention of kidney transplant rejection in people 5 years and older
Prevention of kidney, heart, or liver transplant rejection in people ages 3 months and older; taken with other anti-rejection medications
Myhibbin (mycophenolate mofetil) images
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References
Best studies we foundAmerican Cancer Society. (n.d.). Lymphoma.
Azurity Pharmaceuticals, Inc. (2024). Azurity Pharmaceuticals, Inc. announces FDA approval of Myhibbin™ (mycophenolate mofetil oral suspension).
Hochegger, K., et al. (2006). Acute inflammatory syndrome induced by mycophenolate mofetil in a patient following kidney transplantation. American Journal of Transplantation.
Liqmeds Worldwide Limited. (2024). Myhibbin (mycophenolate mofetil oral suspension) [package insert]. U.S. Food and Drug Administration.
MedlinePlus. (2024). Progressive multifocal leukoencephalopathy.
National Center for Emerging and Zoonotic Infectious Diseases (U.S.). Division of Healthcare Quality Promotion. (2018). Spoons are for soup / Milliliters (mL) are for medicine.
National Human Genome Research Institute. (2014). About phenylketonuria.
Torres, R. J., et al. (2007). Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome. Orphanet Journal of Rare Diseases.
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