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Mresvia

Used for RSV
Used for RSV

MRESVIA is an mRNA vaccine that's used to protect adults 60 years and older from illness caused by respiratory syncytial virus (RSV). This vaccine is injected into the muscle by a trained healthcare professional (HCP), and you only need to get one dose. Some potential side effects of the MRESVIA RSV vaccine include pain at the injection site, tiredness, headache, and muscle pain.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on June 5, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsReferencesPricesMedicare
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What is MRESVIA?

What is MRESVIA used for?

How MRESVIA works

MRESVIA is an mRNA vaccine. This vaccine contains lab-made mRNA (genetic information) that teaches your body to make a part of a protein found on RSV.

Your immune system recognizes that this harmless protein doesn't belong in your body. This causes your immune system to make antibodies against the protein. The antibodies tell other immune cells to get rid of it.

Your immune system learns what the RSV protein looks like. So when you get infected with RSV, your immune system is ready to fight and protect you from infection.

Are you looking for information on Arexvy (RSV vaccine) or Abrysvo (RSV vaccine) instead?

Drug Facts

Common BrandsMRESVIA
Drug ClassVaccine
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$387.75(save 24.60%)
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$292.36
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What are the side effects of MRESVIA?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Pain at the injection site (56%)
  • Feeling tired (31%)
  • Headache (27%)
  • Muscle pain (26%)
  • Joint pain (22%)
  • Underarm swelling or tenderness (15%)
  • Chills (12%)

Other Side Effects

  • Redness at the injection site
  • Swelling at the injection site
  • Fever
  • Nausea or vomiting

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat

Source: FDA

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Feeling faint or lightheaded
  • Weakness and tingling in the feet and legs that spreads to upper body

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of MRESVIA

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Pros

Given as a single dose

Lowers the risk of RSV-related illness by up to 84% in people 60 years and older

Offers protection against RSV-A and RSV-B, two types of the virus

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Cons

Only available as an injection, which might be uncomfortable

Can cause temporary side effects such as headache and muscle aches

Not approved for people younger than 60 years old

pharmacist-tips

Pharmacist tips for MRESVIA

pharmacist

  • Discuss your full medical history with your primary care provider before you get vaccinated with MRESVIA. This vaccine might not work as well for you if you have conditions (or are taking medications) that weaken your immune system.

    • For MRESVIA to be most effective, you should get it during late summer or early fall, just before the start of RSV season. Ask your primary care provider about the best time for you to get your vaccine.

      • After getting the MRESVIA vaccine, stay seated for a few minutes. Vaccines that are injected, like MRESVIA, can sometimes cause fainting.

        • Share your vaccination record with a healthcare professional so they can help you get up to date with all of your vaccines.

          • Tell your primary care provider or pharmacist if you experience any side effects from MRESVIA. You can also report side effects to the Vaccine Adverse Event Reporting System at 1-800-822-7967 and www.vaers.hhs.gov.

            faqs

            Frequently asked questions about MRESVIA

            When will MRESVIA be available?
            According to the manufacturer Moderna, MRESVIA is expected to be available by the 2024/2025 respiratory virus season. Check with your primary care provider or local pharmacy to find out more information.
            Is MRESVIA a live vaccine?
            No, MRESVIA isn't a live vaccine. It doesn't contain any live virus. It's an mRNA vaccine that teaches your body to make a protein that's found on RSV, which causes your immune system to build antibodies against it for protection.
            How well does MRESVIA work to prevent RSV?
            During a clinical study that included over 35,000 older adults, researchers found that MRESVIA was around 84% effective at preventing illness from RSV infection. The vaccine protected people against both types of RSV (A and B).
            When should I get MRESVIA?
            The CDC recommends that older adults get their RSV vaccine in the late summer or early fall. This is because RSV typically spreads in the fall and winter. Ask your primary care provider about whether an RSV vaccination is appropriate for you, and if so, when you should get it.
            What's the difference between MRESVIA, Arexvy, and Abrysvo?
            All three are RSV vaccines that are FDA approved for people ages 60 years and older. But Abrysvo is also approved for people between 32 to 36 weeks of pregnancy. MRESVIA, Arexvy, and Abrysvo are all given as an injection in the muscle. They each work slightly differently. Talk to your primary care provider about which RSV vaccine might be best for you.
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            What are the risks and warnings for MRESVIA?

            MRESVIA can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Severe allergic reaction

            Although rare, it's possible for MRESVIA to cause a severe allergic reaction. Get medical help right away if you experience tightness in your chest; trouble breathing; skin rash; or swelling in your lips, tongue, throat, or face after you get your MRESVIA shot.

            risk-warning

            Fainting

            Some people might feel faint after they get injectable vaccines like MRESVIA. To lower your risk of fainting, stay seated for a while after your vaccination and stand up slowly to make sure you don't fall.

            risk-warning

            Vaccine might not work as well for people with a weakened immune system

            • Risk factors: Medical conditions that weaken the immune system | Taking medications that weaken your immune system

              MRESVIA might not work as well for people with a weakened immune system. Talk to your primary care provider before you get vaccinated with MRESVIA if you have a medical condition that lowers the immune system, such as human immunodeficiency virus (HIV) or cancer. Also speak with your primary care provider if you take medications that weaken your immune system, like high-dose corticosteroids or transplant medications).

              dosage

              MRESVIA dosage forms

              The average cost for 1 carton of 0.5ml prefilled syringe of MRESVIA is $292.36 with a free GoodRx coupon. This is 24.6% off the average retail price of $387.75.
              carton
              Carton
              DosageQuantityPrice as low asPrice per unit
              0.5ml prefilled syringe1 carton$292.36$292.36

              Typical dosing for MRESVIA

              Adults ages 60 years and older: The typical dose is 0.5 mL injected into the muscle by a healthcare professional.

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              How much does MRESVIA cost?

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              Mresvia (brand)
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              $292.36

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              alternatives

              What are alternatives to MRESVIA?

              There are a number of medications that your doctor can prescribe in place of MRESVIA. Compare a few possible alternatives below.
              MRESVIA
              Used for:
              $292.36 Lowest GoodRx priceView Prices
              Arexvy (RSV vaccine)
              Used for:
              $311.12 Lowest GoodRx priceView Prices
              Abrysvo (RSV vaccine)
              Used for:
              $311.57 Lowest GoodRx priceView Prices

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              References

              Best studies we found

              Centers for Disease Control and Prevention. (2024). Fainting and vaccines.

              Centers for Disease Control and Prevention. (2024). Healthcare providers: RSV vaccination for adults 60 years of age and over.

              Centers for Disease Control and Prevention. (2024). RSV vaccines.

              View All References (4)

              MedlinePlus. (2022). What are mRNA vaccines and how do they work?

              Moderna, Inc. (2024). Moderna receives U.S. FDA approval for RSV vaccine mRESVIA(R). AccessWire.

              ModernaTX, Inc. (2024). MRESVIA™ (respiratory syncytial virus vaccine) injectable suspension, for intramuscular use [package insert].

              Wilson, E., et al. (2023). Efficacy and safety of an mRNA-based RSV PreF vaccine in older adults. The New England Journal of Medicine.

              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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