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Abrysvo

Used for RSV
Used for RSV

Abrysvo (RSV vaccine) is a bivalent vaccine used to lower the risk of illness caused by respiratory syncytial virus (RSV). It's FDA-approved for adults ages 60 years and older, and adults who are between 32 and 36 weeks of pregnancy to protect babies during the first 6 months of life. Abrysvo (RSV vaccine) is given as an injection into the muscle and can cause tiredness, headache, and pain at the injection site as side effects.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on November 7, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesReferencesPricesMedicare
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What is Abrysvo (RSV vaccine)?

What is Abrysvo (RSV vaccine) used for?

Prevention of respiratory syncytial virus (RSV) in:

How Abrysvo (RSV vaccine) works

Abrysvo (RSV vaccine) is a recombinant protein subunit vaccine, meaning pieces of the virus are made and put into the vaccine. It helps protect you from respiratory syncytial virus (RSV) infection by triggering your immune system to make proteins called antibodies against the virus. These antibodies will help prevent infection by attacking the virus if it ever infects your body.

Are you looking for information on Arexvy (RSV vaccine) instead?
When does Abrysvo (RSV vaccine) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsAbrysvo
Drug ClassVaccine
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Abrysvo (RSV vaccine) essentials

Health: RSV: senior woman receiving vaccine 1279220076

Abrysvo vs. Arexvy: 6 Ways These RSV Vaccines Compare and How to Choose

Written by Kristianne Hannemann, PharmD
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What are the side effects of Abrysvo (RSV vaccine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Age 60 years and older
  • Tiredness (16%)
  • Headache (13%)
  • Pain at injection site (11%)
  • Muscle pain (10%)
Pregnant females
  • Pain at injection site (41%)
  • Tiredness (46%)
  • Headache (31%)
  • Muscle pain (27%)
  • Nausea (20%)

Other Side Effects

  • Redness at injection site
  • Swelling at injection site
  • Joint pain
  • Nausea
  • Diarrhea

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
Severe allergic reaction: hives, racing heart, difficulty breathing, swelling of the face, lips, tongue, or throat
When do Abrysvo (RSV vaccine) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Pain at injection site
Tiredness
Headache
Muscle pain
Nausea

Source: DailyMed

More on Abrysvo (RSV vaccine) side effects

Health: RSV: side effects rsv vaccine

7 RSV Vaccine Side Effects: What to Expect After Receiving Abrysvo or Arexvy

Written by Kristianne Hannemann, PharmD

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Feeling faint or lightheaded
  • Weakness and tingling in the feet and legs that spreads to upper body

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Abrysvo (RSV vaccine)

thumbs-up

Pros

Lowers risk of RSV-related illness by up to 86% in people 60 years and older

Given as a single dose

Offers protection against RSV-A and RSV-B, two types of the virus

thumbs-down

Cons

Injection might be uncomfortable

Not approved for people under 60 years old unless you're pregnant

Can cause tiredness and headache as side effects

pharmacist-tips

Pharmacist tips for Abrysvo (RSV vaccine)

pharmacist

  • Before getting Abrysvo (RSV vaccine), discuss your full medical history with your provider. If you have conditions (or are taking medications) that weaken your immune system, this vaccine might not work as well for you.

    • Injectable vaccines like Abrysvo (RSV vaccine) can sometimes cause fainting. After getting the vaccine, stay seated for a few minutes and make sure you don't feel dizzy or faint when carefully standing up.

      • Abrysvo (RSV vaccine) isn't made with latex and doesn't contain preservatives. However, you should tell your provider all of your allergies before getting Abrysvo (RSV vaccine) so they can make sure it's safe for you.

        • Share a list of your previous vaccinations with your provider, so they can make sure you're up to date with all of your vaccines.

          faqs

          Frequently asked questions about Abrysvo (RSV vaccine)

          When will Abrysvo (RSV vaccine) be available?
          Abrysvo (RSV vaccine) is available now. Talk to your healthcare provider or visit the manufacturer website to find a location near you where you can get this vaccine.
          Who needs Abrysvo (RSV vaccine)?
          Abrysvo (RSV vaccine) is FDA-approved for adults ages 60 years and older, and people who are between 32 and 36 weeks of pregnancy (to pass protection onto their babies during the first 6 months of life). While RSV might cause mild, cold-like symptoms in most people, older adults and infants are at higher risk for severe symptoms from RSV. Talk with your provider to see if you need to get Abrysvo (RSV vaccine).
          Is the RSV vaccine a one time shot?
          Yes. Currently, the CDC recommends one dose of either RSV vaccine (Abrysvo or Arexvy) for adults age 60 years and older after a discussion with their healthcare provider. But only Abrysvo (RSV vaccine) is approved as a one-time shot for people who are between 32 and 36 weeks of pregnancy. Studies are ongoing to see if additional doses are needed over time.
          Is there a vaccine for RSV for adults?
          At this time, there are two RSV vaccines available for certain adults: 1) those who are pregnant between 32 and 36 weeks (Abrysvo), and 2) those who are 60 years and older (Abrysvo and Arexvy). Currently, there aren't any RSV vaccines approved for adults who fall outside of these categories. But the manufacturer of Abrysvo (RSV vaccine) has announced plans to study it in younger adults who have a weakened immune system. In the mean time, there are steps you can take to lower your risk of infection, such as washing your hands often with soap and water.
          When should I get the RSV vaccine?
          If you're pregnant, the CDC recommends to get one dose of Abrysvo (RSV vaccine) between 32 and 36 weeks of pregnancy. If you're 60 years or older, it's recommended to get a dose between September and January, since this is the time the RSV virus is most active. Discuss the best timing to get your RSV vaccine with your provider.
          Can RSV vaccine be given with other vaccines?
          Always check with your provider about which vaccines are safe to get at the same time. There's limited information on the effects of combining vaccines. So far, research suggests that people age 65 years and older can receive both Abrysvo (RSV vaccine) and the flu shot without any major safety concerns.
          Is RSV vaccine live virus?
          No. The RSV vaccines like Abrysvo (RSV vaccine) are made with inactive (dead) parts of the RSV virus, so they can't cause you to become infected.
          What's the difference between Abrysvo (RSV vaccine) and Arexvy?
          Both Abrysvo (RSV vaccine) and Arexvy (RSV vaccine) are newly FDA-approved RSV vaccines that can be used in people 60 years and older. But only Abrysvo (RSV vaccine) is also approved for people between 32 to 36 weeks of pregnancy. They're made by two different manufacturers, and are slightly different. Abrysvo (RSV vaccine) is considered a bivalent vaccine, which means it contains proteins from two different types of RSV. Arexvy isn't a bivalent vaccine, but studies have shown it still protects against the same types of RSV as Abrysvo (RSV vaccine). For both vaccines, you only need one dose at this time. Neither of them contains preservatives.
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          What are the risks and warnings for Abrysvo (RSV vaccine)?

          Abrysvo (RSV vaccine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Potential risk of preterm (early) birth

          A higher amount of preterm (early) births were observed in pregnant females who got Abrysvo (RSV vaccine) compared to those who didn't during clinical studies. It's not clear if this was due to the vaccine, or another cause. To lower the potential risk of this happening, your provider will administer Abrysvo (RSV vaccine) between 32 and 36 weeks of your pregnancy.

          risk-warning

          Severe allergic reaction

          Although rare, it's possible for Abrysvo (RSV vaccine) to cause a severe allergic reaction. Get medical help right away if you experience skin rash, tightness in your chest, trouble breathing, or swelling in your lips, tongue, throat, or face after receiving Abrysvo (RSV vaccine).

          risk-warning

          Fainting

          Injectable vaccines like Abrysvo (RSV vaccine) can cause some people to feel faint afterwards. Stay seated for a while after getting your vaccine, and stand up slowly to make sure you don't fall if you feel faint or dizzy.

          risk-warning

          Vaccine not working as well (in people with weakened immune systems)

          • Risk factors: Medical conditions that weaken the immune system | Taking medications that weaken your immune system

            Abrysvo (RSV vaccine) might not work as well in people with a weakened immune system. If you have any medical conditions (e.g., human immunodeficiency virus or HIV, cancer) or take medications that weaken your immune system (e.g., high-dose corticosteroids, transplant medications, cancer medications), talk to your provider first before getting Abrysvo (RSV vaccine).

            dosage

            Abrysvo (RSV vaccine) dosage forms

            The average cost for 1 kit of 1 dose of Abrysvo (RSV vaccine) is $313.89 with a free GoodRx coupon. This is 12.55% off the average retail price of $358.95.
            kit
            Kit
            DosageQuantityPrice as low asPrice per unit
            1 dose1 kit$313.89$313.89

            Typical dosing for Abrysvo (RSV vaccine)

            • The typical dose is 0.5 mL injected into the muscle by a healthcare provider.

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            How much does Abrysvo (RSV vaccine) cost?

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            alternatives

            What are alternatives to Abrysvo (RSV vaccine)?

            There are a number of medications that your doctor can prescribe in place of Abrysvo (RSV vaccine). Compare a few possible alternatives below.
            Abrysvo (RSV vaccine)
            Used for:

            Prevention of respiratory syncytial virus (RSV) in:

            $313.89 Lowest GoodRx priceView Prices
            Arexvy (RSV vaccine)
            Used for:
            $326.85 Lowest GoodRx priceView Prices
            latest news

            What is the latest news about Abrysvo (RSV vaccine)?

            Compare the differences between Abrysvo, an RSV vaccine for adults, and Beyfortus, a preventative antibody injection for children. Read on to learn more.

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            Arexvy and Abrysvo are two FDA-approved RSV vaccines. Here are the main ways that they compare, plus how to choose between them.

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            Fatigue, muscle pain, and nausea are common side effects of the RSV vaccine. Learn more about what to expect after getting Abrysvo or Arexvy here.

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            References

            Best studies we found

            Centers for Disease Control and Prevention. (2020). Fainting (Syncope) after Vaccination.

            Centers for Disease Control and Prevention. (2022). People at high risk for severe RSV infection.

            Centers for Disease Control and Prevention. (2023). Healthcare providers: RSV vaccination for pregnant people.

            View All References (9)

            Centers for Disease Control and Prevention. (2023). Immunization Schedules.

            Centers for Disease Control and Prevention. (2023). Respiratory syncytial virus (RSV) vaccine VIS.

            Centers for Disease Control and Prevention. (2024). Frequently asked questions about RSV vaccine for adults.

            Centers for Disease Control and Prevention. (2024). RSV prevention.

            Immunize.org. (2024). Vaccine Recommendations During Pregnancy. Ask the Experts: RSV (Respiratory Syncytial Virus).

            Pfizer Inc. (2023). Find Pfizer's RSV vaccine near you and make your appointment today.

            Pfizer Inc. (2023). U.S. FDA approves ABRYSVO™, Pfizer’s vaccine for the prevention of respiratory syncytial virus (RSV) in older adults. Business Wire.

            Pfizer Laboratories Div Pfizer Inc. (2023). Abrysvo- respiratory syncytial virus vaccine kit [package insert]. DailyMed.

            World Health Organization. (2020). How do vaccines work?

            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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