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Arexvy

Used for RSV
Used for RSV

Arexvy (RSV vaccine) is a FDA-approved vaccine used to lower the risk of illness caused by respiratory syncytial virus (RSV). It's the first RSV vaccine approved in the United States. You can receive Arexvy (RSV vaccine) if you're age 60 years or older, and in some cases, starting at age 50 if you're at high risk for serious problems if infected. But first, you should discuss the risks and benefits with your primary care provider. Arexvy (RSV vaccine) is given once as a shot into the muscle, typically in your upper arm. Common side effects of this vaccine include injection site reactions, headache, joint and muscle aches, and feeling tired.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Connie Zheng, PharmD
Last reviewed on March 14, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsReferencesPricesMedicare
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What is Arexvy (RSV vaccine)?

What is Arexvy (RSV vaccine) used for?

How Arexvy (RSV vaccine) works

Arexvy (RSV vaccine) is an recombinant subunit vaccine. Pieces of RSV are put into the vaccine. Once inside your body, these pieces of RSV triggers the immune system to make proteins called antibodies against RSV. These antibodies will help prevent infection by attacking the virus if it ever infects your body.

Drug Facts

Common BrandsArexvy
Drug ClassVaccine
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Arexvy (RSV vaccine) essentials

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5 Things Older Adults Should Know About Arexvy: The First RSV Vaccine

Written by Alyssa Billingsley, PharmD
Health: RSV: senior woman receiving vaccine 1279220076

Abrysvo vs. Arexvy: 6 Ways These RSV Vaccines Compare and How to Choose

Written by Kristianne Hannemann, PharmD
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What are the side effects of Arexvy (RSV vaccine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Pain at the injection site (61%)
  • Feeling tired (34%)
  • Muscle pain (29%)
  • Headache (27%)
  • Joint pain (18%)

Other Side Effects

  • Redness at the injection site
  • Swelling at the injection site
  • Fever

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe allergic reaction: hives, trouble breathing, racing heart, swelling of the face, lips, tongue, or throat
When do Arexvy (RSV vaccine) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Pain at the injection site
Feeling tired
Muscle pain
Joint pain
Headache

Source: DailyMed

More on Arexvy (RSV vaccine) side effects

Health: RSV: side effects rsv vaccine

7 RSV Vaccine Side Effects: What to Expect After Receiving Abrysvo or Arexvy

Written by Kristianne Hannemann, PharmD

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Feeling faint or lightheaded
  • Weakness and tingling in the feet and legs that spreads to upper body

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Arexvy (RSV vaccine)

thumbs-up

Pros

Given as a single dose

Lowers risk of RSV-related illness by about 83% in people 60 years and older

One shot gives protection over 2 RSV seasons

thumbs-down

Cons

Not approved for use in people under 50 years old

Can cause unpleasant side effects, like muscle aches, tiredness, and headache

Can only be given as an injection into the muscle by a healthcare professional

pharmacist-tips

Pharmacist tips for Arexvy (RSV vaccine)

pharmacist

  • Talk to your healthcare professional (HCP) about your vaccine history, so they can make sure you're up to date with all of your vaccines.

    • After receiving Arexvy (RSV vaccine), it can be helpful to stay seated for a while. Injectable vaccines like Arexvy (RSV vaccine) can sometimes cause fainting.

      • It's common to experience feeling tired, headache, muscle aches, and joint pain after your vaccination with Arexvy (RSV vaccine). These side effects should go away after a few days. If they don't or get worse, contact your HCP.

        • Arexvy (RSV vaccine) doesn't contain preservatives, and isn't made with latex. However, you should tell your HCP all of your allergies before getting Arexvy (RSV vaccine) so they can make sure it's safe for you.

          faqs

          Frequently asked questions about Arexvy (RSV vaccine)

          Is Arexvy (RSV vaccine) an mRNA vaccine?
          No, Arexvy (RSV vaccine) isn't an mRNA vaccine. An mRNA vaccine contains genetic material that teach cells in your body to make parts of a germ, such as a virus. Once made, these parts then trigger your immune system to make antibodies against the germ. Instead, Arexvy (RSV vaccine) is a recombinant vaccine. It already contains pieces of RSV, which trigger your body to make antibodies to fight RSV when they're injected into your body.
          Is Arexvy (RSV vaccine) a live vaccine?
          Arexvy (RSV vaccine) doesn't contain any live virus, and isn't a live vaccine. Instead, it's a recombinant vaccine, meaning it contains pieces of RSV that can't cause an infection.
          Who makes Arexvy (RSV vaccine)?
          Arexvy (RSV vaccine) is manufactured by GlaxoSmithKline Biologicals.
          Is Arexvy (RSV vaccine) a one time dose?
          Yes, Arexvy (RSV vaccine) is given as a one-time dose. Additional doses (e.g., booster shots) aren't recommended at this time.
          Can Arexvy (RSV vaccine) be given with other vaccines?
          Yes, you can receive Arexvy (RSV vaccine) with other vaccines on the same day. If you do, there's a chance that you might experience more, or more intense, side effects. Discuss the best timing to receive your vaccines with your pharmacist or primary care provider.
          Does Arexvy (RSV vaccine) contain egg?
          No, Arexvy (RSV vaccine) doesn't contain egg. If you have an egg allergy, this vaccine shouldn't trigger a reaction. Remember to discuss all of your allergies with your healthcare team before getting any vaccine, including Arexvy (RSV vaccine).
          How well does Arexvy (RSV vaccine) work to prevent RSV?
          In clinical studies, Arexvy (RSV vaccine) lowered the risk of developing RSV illness by about 83% compared to placebo during one RSV season (typically fall and winter). Studies also showed that it lowered the risk of serious RSV infection by 94% compared to placebo. Keep in mind that research of Arexvy (RSV vaccine) is still ongoing. Scientists will continue to look at how well it protects against RSV after multiple RSV seasons and with repeat vaccinations.
          What is the difference between Arexvy (RSV vaccine) and Abrysvo?
          Arexvy and Abrysvo are two RSV vaccines that are available as one-time shots injected into your muscle by a trained healthcare professional. While both vaccines are FDA-approved for people ages 60 years and older, Abrysvo is also approved for pregnant people between 32 to 36 weeks of pregnancy. The two vaccines have similar side effects, and the CDC doesn't prefer one over the other for older adults. Follow up with your primary care provider for more information.
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          What are the risks and warnings for Arexvy (RSV vaccine)?

          Arexvy (RSV vaccine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Severe allergic reaction

          Although rare, it's possible for Arexvy (RSV vaccine) to cause a severe allergic reaction. Get medical help right away if you experience tightness in your chest, trouble breathing, skin rash, or swelling in your lips, tongue, throat, or face after receiving Arexvy (RSV vaccine).

          risk-warning

          Fainting

          Some people feel faint after getting injectable vaccines like Arexvy (RSV vaccine). Stay seated for a while after getting your vaccine, and stand up slowly to make sure you don't fall if you suddenly feel faint.

          risk-warning

          Vaccine not working as well (in people with weakened immune systems)

          • Risk factors: Medical conditions that weaken the immune system | Taking medications that weaken your immune system

            Arexvy (RSV vaccine) might not work as well in people with a weakened immune system. If you have any medical conditions (e.g., human immunodeficiency virus or HIV, cancer) or take medications that weaken your immune system (e.g., high-dose corticosteroids, transplant medications, cancer medications), talk to your primary care provider first before getting Arexvy (RSV vaccine).

            dosage

            Arexvy (RSV vaccine) dosage forms

            The average cost for 1 carton of 1 dose of Arexvy (RSV vaccine) is $314.80 with a free GoodRx coupon. This is 12.99% off the average retail price of $361.81.
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            1 dose1 carton$314.80$314.80

            Typical dosing for Arexvy (RSV vaccine)

            The typical dose is 0.5 mL injected into the muscle by a healthcare professional.

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            How much does Arexvy (RSV vaccine) cost?

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            Arexvy (brand)
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            alternatives

            What are alternatives to Arexvy (RSV vaccine)?

            There are a number of medications that your doctor can prescribe in place of Arexvy (RSV vaccine). Compare a few possible alternatives below.
            Arexvy (RSV vaccine)
            Used for:
            $314.80 Lowest GoodRx priceView Prices
            Abrysvo (RSV vaccine)
            Used for:
            $325.99 Lowest GoodRx priceView Prices
            latest news

            What is the latest news about Arexvy (RSV vaccine)?

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            The RSV vaccine for adults can cost about $350 without insurance. But it is covered by many insurance plans, including Medicare. Find out prices and ways to save.

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            Arexvy and Abrysvo are two FDA-approved RSV vaccines. Here are the main ways that they compare, plus how to choose between them.

            Abrysvo vs. Arexvy: 6 Ways These RSV Vaccines Compare and How to Choose

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            References

            Best studies we found

            Centers for Disease Control and Prevention. (2024). Healthcare Providers: RSV Vaccination for Adults 60 Years of Age and Over.

            Centers for Disease Control and Prevention. (2020). Fainting (syncope) after vaccination.

            Centers for Disease Control and Prevention. (2022). People at high risk for severe RSV infection.

            View All References (8)

            Centers for Disease Control and Prevention. (2023). Respiratory syncytial virus infection (RSV) - For healthcare providers.

            Centers for Disease Control and Prevention. (2024). Frequently Asked Questions About RSV Vaccine for Adults.

            Centers for Disease Control and Prevention. (2024). Respiratory Syncytial Virus Infection (RSV)

            Centers for Disease Control and Prevention. (2024). RSV in older adults and adults with chronic medical conditions.

            GlaxoSmithKline Biologicals SA. (2023). Arexvy- respiratory syncytial visus vaccine recombinant, adjuvanted kit [package insert]. DailyMed.

            U.S. Department of Health and Human Services. (2022). Vaccine types.

            U.S. Food & Drug Administration. (2023). FDA Approves First Respiratory Syncytial Virus (RSV) Vaccine.

            World Health Organization. (2020). How do vaccines work?

            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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