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Mitigare
Used for Gout
Used for Gout
Colchicine 0.6 mg capsule (Mitigare) is used to prevent gout flares (attacks) in adults. It works as an anti-inflammatory medication. Colchicine (Mitigare) is taken by mouth once or twice each day. Side effects include diarrhea, vomiting, stomach pain and nausea. This gout medication is available in a brand-name and generic version.
What is Colchicine (Mitigare)?
What is Colchicine (Mitigare) used for?
- Prevention of gout flares in adults
How Colchicine (Mitigare) works
Colchicine (Mitigare) is an anti-inflammatory medication. It works by blocking certain immune cells that cause inflammation. This can help prevent gout attacks.
Drug facts
| Common Brands | Mitigare |
|---|---|
| Drug Class | Antigout |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Colchicine (Mitigare)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Stomach pain
Less Common Side Effects
- Rash
- Muscle weakness
- Muscle pain
- Low blood cell counts
Colchicine (Mitigare) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Taking too much medication (overdose): severe dehydration, multiple organ failure, trouble breathing
- Low blood cell counts: fever, tiredness, chills, cough, trouble breathing, pale skin, fast heart rate, lightheadedness, easy bleeding or bruising
- Severe muscle damage (rhabdomyolysis): dark brown urine, severe muscle weakness or pain, fever, tiredness, trouble moving arms or legs
When do Colchicine (Mitigare) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Diarrhea
Nausea
More on Colchicine (Mitigare) side effects
The following Colchicine (Mitigare) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Black, tarry stools
blood in the urine or stools
burning, "crawling", or tingling feeling in the skin
difficulty with breathing when exercising
fever with or without chills
headache
large, hive-like swellings on the face, eyelids, mouth, lips, or tongue
muscle weakness
numbness in the fingers or toes (usually mild)
peeling of the skin
pinpoint red spots on the skin
redness of the skin
skin rash or hives
sores, ulcers, or white spots on the lips or in the mouth
swelling
tenderness
unusual bleeding or bruising
unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
burning feeling in the stomach, throat, or skin
chest pain or discomfort
chills
cold, clammy, pale skin
confusion
diarrhea (severe or bloody)
dizziness
general feeling of illness
headache
irregular heartbeat
irregular, fast, slow, or shallow breathing
muscle weakness (very severe)
nausea, stomach pain, or vomiting (severe)
seizures
slow heart rate
unusual tiredness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$86.66
GoodRx discount
$46.89
Pros and cons of Colchicine (Mitigare)
Pros
- A first-choice option for preventing gout attacks
- Can take with or without food
Cons
- Has many interactions, like with statins and grapefruit
- Not known if the capsules work well to treat a gout flare you're having
Pharmacist tips for Colchicine (Mitigare)
- Take colchicine (Mitigare) every day exactly as prescribed. Taking it each day can help keep gout attacks at bay.
- Take colchicine (Mitigare) with or without food. It might help to take it with food to reduce stomach upset, which is a common side effect. But avoid grapefruit or grapefruit juice because it can raise your risk of side effects instead.
- Swallow the colchicine (Mitigare) capsule whole. Don't chew, open, or break them because that could affect how the medication works. If you have trouble swallowing pills whole, talk to your prescriber.
- Ask your prescriber ahead of time what to do if you have a gout attack while taking colchicine (Mitigare). Don't take extra capsules of colchicine (Mitigare). It's not known if the capsules work well to treat the gout attack. Also, taking too much of the medication can cause a life-threatening overdose.
- Reach out to your care team if you have side effects, like nausea, vomiting, diarrhea, or stomach pain. These can be early signs that your dose is too high for you. Your prescriber might need to adjust your dose.
- Avoid alcohol while taking colchicine (Mitigare). This medication can cause stomach upset and headaches. And alcohol can make these side effects worse. Alcohol itself can also raise the risk of having a gout flare.
- Tell your care team about all the medications you take or plan to take. They can check for drug interactions with colchicine (Mitigare) and adjust your treatment if needed. Some medications, like diltiazem (Cardizem), statins, and some antifungals, can raise your risk of side effects. Your care team can help keep you safe.
- If you're a male and you plan to have children, talk to your prescriber. In rare cases, colchicine (Mitigare) might affect fertility and make it harder to have a child. This effect might be reversible after you stop taking the medication.
More on Colchicine (Mitigare) tips
Risks and warnings for Colchicine (Mitigare)
Colchicine (Mitigare) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Life-threatening overdose
An overdose of colchicine (Mitigare) can happen if you take too much of the medication. This is serious and life-threatening. Only take colchicine (Mitigare) as directed by your prescriber. And keep the medication out of reach from children.
Early symptoms of a colchicine (Mitigare) overdose include stomach pain, nausea, vomiting, and diarrhea. These can lead to serious dehydration. More dangerous symptoms can happen later. That's why it's important to get help as soon as possible. If you think you or someone else has overdosed on colchicine (Mitigare), call the Poison Control Center at 1-800-222-1222 or call 911 right away.
Low blood cell counts
- Risk factors: Taking other medications that raise the amount of colchicine (Mitigare) in the body | Kidney or liver problems
Colchicine (Mitigare) can sometimes lower your blood cell counts, which can be serious. Low white blood cells can put you at risk of infection. Low platelets can make you bleed or bruise more easily. And low red blood cells can lead to anemia.
Tell your care team right away if you have signs of a low blood cell count while taking colchicine (Mitigare). These can include fever, tiredness, chills, cough, or trouble breathing. Other signs include pale skin, fast heart rate, dizziness, or easy bruising or bleeding.
Drug interactions
Colchicine (Mitigare) can interact with many medications. These interactions can make the level of colchicine (Mitigare) in your body get too high. This can lead to dangerous side effects.
Some examples include heart medications called calcium channel blockers (CCBs) like diltiazem (Cardizem). It can also include digoxin (Lanoxin). Other examples are statins and fibrates for cholesterol. Even more are certain antifungals and antivirals.
Make sure your healthcare team has a full list of the medications you take. Also let your prescriber know if you have any liver or kidney problems. These health issues can make the effects of some drug interactions worse. Your prescriber can adjust the dose of your medications if needed to keep you safe.
Nerve or muscle toxicity
- Risk factors: Older adults | Taking statins or fibrates with colchicine (Mitigare) | Taking other medications that raise the amount of colchicine (Mitigare) in the body | Kidney problems
Some people who take colchicine (Mitigare) for a long time have had nerve or muscle problems. Although rare, it can include a serious condition called rhabdomyolysis, where muscles get damaged and break down.
The risk of muscle damage is higher for older people and those with kidney problems. It also might be higher if you take statins, fibrates, or cyclosporine (Neoral, Gengraf, or Sandimmune).
If you have muscle pain or weakness, dark or red urine, or trouble moving your arms or legs while taking colchicine (Mitigare), get medical help right away. These can be signs of muscle or nerve problems. You might need to stop taking the medication. These symptoms often go away within a week, but sometimes months, after stopping.
Colchicine (Mitigare) dosage
The average cost for 30 capsules of 0.6mg of Colchicine (Mitigare) is $46.89 with a free GoodRx coupon. This is 45.89% off the average retail price of $86.66. 
Capsule
Capsule| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 0.6mg | 30 capsules | $46.89 | $1.56 |
Typical dosage for Colchicine (Mitigare)
The typical dose is 0.6 mg by mouth once or twice a day. The maximum dose is 1.2 mg per day.
Interactions between Colchicine (Mitigare) and other drugs
Colchicine (Mitigare) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Colchicine (Mitigare). Please note that only the generic name of each medication is listed below.
More on Colchicine (Mitigare) interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Amiodarone
- Atazanavir
- Boceprevir
- Carvedilol
- Clarithromycin
- Cobicistat
- Conivaptan
- Cyclosporine
- Darunavir
- Diltiazem
- Dronedarone
- Erythromycin
- Flibanserin
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Lapatinib
- Lopinavir
- Nefazodone
- Nelfinavir
- Nilotinib
- Posaconazole
- Quinidine
- Ranolazine
- Ritonavir
- Saquinavir
- Sunitinib
- Telaprevir
- Telithromycin
- Tipranavir
- Vemurafenib
- Verapamil
- Voriconazole
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abametapir
- Amprenavir
- Aprepitant
- Atorvastatin
- Capmatinib
- Crizotinib
- Delavirdine
- Fenofibrate
- Fenofibric Acid
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosaprepitant
- Fosnetupitant
- Gemfibrozil
- Imatinib
- Interferon Alfa-2a
- Lasmiditan
- Letermovir
- Lovastatin
- Mibefradil
- Mifepristone
- Netupitant
- Pitavastatin
- Pravastatin
- Reserpine
- Rosuvastatin
- Simvastatin
- Tacrolimus
- Venetoclax
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Bezafibrate
- Ciprofibrate
- Clofibrate
- Digoxin
- Fluvastatin
How much does Colchicine (Mitigare) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Colchicine (Mitigare) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Colchicine (Mitigare) will not be safe for you to take.
- Kidney or liver problems and also take a medication that interacts with colchicine (Mitigare)
- Both kidney and liver problems
What are alternatives to Colchicine (Mitigare)?
There are a number of medications that your doctor can prescribe in place of Colchicine (Mitigare). Compare a few possible alternatives below.
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Colchicine (Mitigare) images
