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Mircera

methoxy polyethylene glycol-epoetin beta
Used for Anemia, Kidney Disease
Used for Anemia, Kidney Disease

Mircera is a medication that's used to treat anemia (low red blood cells) in people who have kidney problems. It's approved for people age 5 years and older who are on dialysis, though it can also be used for adults who aren't on dialysis. Mircera is an injection that can be given by your healthcare provider, but you can give the injection to yourself at home in some cases after you get trained on how to use it. The dose is given once every two weeks or once a month. This medication can cause high blood pressure as a side effect, so your provider will check that your blood pressure is under control before you start treatment with Mircera.

Last reviewed on September 10, 2023
basics-icon

What is Mircera?

What is Mircera used for?

How Mircera works

Mircera is a type of erythropoiesis-stimulating agent (ESA) called an erythropoietin receptor activator. It attaches to the same receptor (signaling protein) that a hormone in the body called erythropoietin does. This tells the body to make more red blood cells.

Are you looking for information on Mirena (levonorgestrel) instead?

Drug Facts

Common BrandsMircera
Drug ClassErythropoiesis-stimulating agent (ESA)
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Mircera?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

Note: These side effects were reported by adults taking Mircera. Side effects might differ in children.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Blood clot: redness, swelling, or pain in one leg; chest pain; vision problems; shortness of breath; sudden confusion; trouble speaking; trouble walking; fainting
  • Serious allergic or skin reaction: trouble breathing, fast heartbeat, skin rash, blistering skin, swelling in the face or throat, fever

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
  • Heart attackpain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • Increase in blood pressure
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Seizures
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Mircera

thumbs-up

Pros

Long-lasting, so it only needs to be given once or twice a month

Can be given at home in certain situations

Comes in prefilled syringes for easier use

Can use for children age 5 and older

thumbs-down

Cons

Not recommended for use in anemia caused by chemotherapy nor as a substitute for blood transfusions

Can't use if you have uncontrolled high blood pressure

Only works if you have enough iron in your blood

Hasn't been shown to improve quality of life, fatigue, or well-being

pharmacist-tips

Pharmacist tips for Mircera

pharmacist
  • Make sure your provider's office and pharmacy have an updated list of your allergies. Mircera contains mannitol, which can cause an allergic reaction.

    • Mircera must be given into the vein if you or your child is under the age of 18. For adults, the medication can be given intravenously (IV, into the vein) or subcutaneously (under the skin of the stomach, arm, or thigh).

      • Make sure that you get your blood work done on time while you're taking Mircera. These blood tests check your hemoglobin and iron levels. This helps your provider track how well the medication is working for you and whether you need any changes to your treatment plan (i.e., supplemental iron therapy).

        • Check your blood pressure as directed and take any blood pressure medications as prescribed while you're taking Mircera. Mircera can raise your blood pressure, so it's important to make sure your blood pressure stays under control. Let your provider know if your blood pressure reading is unusually high.

          Tips on how to use Mircera at home (if instructed and trained by your provider)

          • Make sure you understand how to properly use Mircera at home. Your provider or pharmacist should've carefully gone over the instructions with you. Review the instructions for the subcutaneous injection (under the skin) or intravenous injection (into the vein through a special access port). Ask your provider or pharmacist if you have any questions about how to inject Mircera.

            • Store Mircera in the refrigerator (not in the freezer). Keep Mircera in its original carton to protect it from light. If you don't have access to a refrigerator, you can keep medication at room temperature for up to 30 days; throw away the medication after this time.

              • Always inspect the medication before you prepare for your Mircera injection. Make sure the liquid inside the syringe isn't looking cloudy, leaking out, or containing any particles (solid chunks). If it has particles, is discolored, or is foamy, don't use it. Instead, contact your provider or pharmacy about getting a replacement syringe. Don't shake the syringes.

                • After injecting the medication, throw away the Mircera syringe in a sharps container or something made of heavy-duty plastic (like an empty milk carton or laundry detergent bottle). This helps lower the risk of needle-stick injuries. Don't throw away needles or syringes in your trash can. Visit the FDA's website to learn about throwing away your sharps container safely in your state.

                  faqs

                  Frequently asked questions about Mircera

                  How do you administer Mircera injection?
                  If you have a port for hemodialysis, Mircera can be given into the vein through the port if your provider says it's okay. Otherwise, you can inject Mircera under the skin in the stomach, back of the arm, or front of the thigh if you're an adult. For children, the medication is given through their vein (intravenously or IV) only. If your provider allowed you or your child to take Mircera at home, review the step-by-step instructions on how to safely use the prefilled syringe to administer the medication (under the skin or through an IV). Ask your provider or pharmacist if you're unsure about any step.
                  How long does it take for Mircera to work?
                  In clinical studies, a single Mircera dose helped raise participants' hemoglobin levels after about 1 to 2 weeks. Hemoglobin is a protein found in red blood cells that providers measure to check how well Mircera is treating your anemia. Keep in mind that it takes time for your body to make new red blood cells, so your provider will continuously check your hemoglobin levels during treatment and change your dose accordingly, if needed.
                  How often do you take Mircera?
                  Mircera is typically given once every two weeks or once a month. This will depend on your age and whether or not you're on dialysis.
                  Can I save any leftover medication in each Mircera syringe and pool it together?
                  No, don't save leftover medication in any of your Mircera syringes nor pool them together for later use. The single-dose syringes don't have any preservatives in them to prevent the spread of germs, so using leftover medication could lead to serious infections. You also might not receive the correct dose of Mircera that you need if you use or pool leftover medication. Always put used Mircera syringes in your sharps container right away.
                  Why do I need to take iron supplements with Mircera?
                  Mircera will tell your body to make more red blood cells, but your body also needs enough iron to do this. If your iron levels are too low, your body might not respond to Mircera and the medication might not work as well for you. Before starting Mircera, your provider will check your iron levels and prescribe iron supplements if your iron levels are too low.
                  Is Mircera available in the United States?
                  Yes, Mircera is available as a brand-name product in the United States. There's currently no lower-cost generic available yet. Speak with your provider about how and where to get the medication if you're prescribed Mircera.
                  Is Mircera the same as epoetin alfa?
                  No, Mircera isn't the same as epoetin alfa (Procrit, Epogen), even though both medications work well to treat anemia caused by chronic kidney disease (CKD). They work very similarly by telling our body to make red blood cells, but there are a few key differences. Mircera lasts longer in the body than epoetin alfa (Procrit, Epogen). Mircera also doesn't need to be injected as often (once or twice a month compared to three times a week). But unlike epoetin alfa (Procrit, Epogen), Mircera can't be used for cancer-related anemia.
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                  What are the risks and warnings for Mircera?

                  Mircera can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Higher risk of death, heart attack, stroke, and blood clots

                  • Risk factors: History of heart problems or stroke | Uncontrolled high blood pressure | Cancer | Getting surgery | High target hemoglobin level | Inadequate hemoglobin response to Mircera

                    Studies found that ESAs like Mircera can raise the risk of death, blood clots, and serious conditions, such as heart attack, stroke and heart failure. The risk might be higher in people with a history of heart-related conditions and in those with a target hemoglobin level of greater than 11 g/dL. Keep in mind that we don't know what target hemoglobin level or ESA dose would put you at less of a risk. In general, your provider will make sure that you take the lowest dose of Mircera to help with your anemia. Make sure you have your blood drawn regularly so your provider can monitor your body's response to Mircera.

                    risk-warning

                    Not for use in people with anemia due to chemotherapy

                    Unlike other medications in the same drug class, Mircera isn't approved to treat anemia caused by cancer chemotherapy. Researchers had to stop clinical trials early when they found that more deaths occurred in people who took Mircera than in those who took another ESA.

                    risk-warning

                    High blood pressure

                    Mircera can raise your blood pressure. For this reason, the medication can't be used if you have high blood pressure that isn't under control. If needed, your provider will prescribe blood pressure medications to help manage your blood pressure before you start Mircera. And during treatment, it's important that you continue any blood pressure medications and dietary plans that are helping to keep your blood pressure under control. Your provider might pause your treatment with Mircera or lower your Mircera dose if your blood pressure becomes too high while you're taking the medication. They might also add more blood pressure-lowering medications if possible.

                    risk-warning

                    Seizures

                    In clinical studies, some people taking Mircera had seizures during treatment. To be safe, your provider will closely monitor you for any pre-seizure symptoms during the first few months of treatment. Contact your provider if you have any pre-seizure symptoms, such as a migraine, sensitivity to light or sound, or changes in mood or behavior. Get medical help if you do have a seizure.

                    risk-warning

                    Possible to have no response or to lose response to the medication

                    • Risk factors: Low iron levels | Bleeding | Infection | Inflammation

                      Sometimes, Mircera doesn't work or stops working after a while. If your anemia doesn't seem to get better during treatment, your provider will look for potential factors that might be causing the anemia. One possible reason is low iron levels, so it's important to take iron supplements if prescribed or directed.

                      risk-warning

                      Severe allergic and skin reactions

                      In some rare cases, Mircera can cause a serious allergic reaction or a severe skin reaction. Stop using this medication and get medical help right away if you develop trouble breathing, swelling in the face or throat, blistering or peeling skin, or rash at any point during treatment.

                      dosage

                      Mircera dosage forms

                      Typical dosing for Mircera

                      For people who haven't had treatment with an ESA before

                      • Adults who are on dialysis: The typical starting dose is 0.6 mcg/kg of body weight given as an injection under the skin or into the vein once every 2 weeks.

                      • Adults who aren't on dialysis: The typical starting dose is 1.2 mcg/kg of body weight given as an injection under the skin once a month.

                      • Children ages 5 to 17 years old who are on dialysis: The dose will depend on your child's previous ESA medication dose. Mircera is typically given as an injection into the vein once every 4 weeks.

                      For people who've had treatment with an ESA before

                      • Adults only: Your Mircera dose will be based on the dose of your previous ESA therapy. Mircera is given as an injection either into a vein or under the skin, once every 2 weeks or once a month.

                      Your provider will adjust your Mircera dose based on your hemoglobin levels.

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                      contraindications-icon

                      Mircera contraindications

                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Mircera will not be safe for you to take.
                      alternatives

                      What are alternatives to Mircera?

                      There are a number of medications that your doctor can prescribe in place of Mircera. Compare a few possible alternatives below.
                      Mircera
                      Used for:
                      $225.60 Lowest GoodRx priceView Prices
                      Used for:
                      • Treatment of anemia due to chemotherapy, chronic kidney disease, and zidovudine use in HIV-infected patients

                      • Reduction of allogeneic red blood cell transfusions in patients having elective, noncardiac, nonvascular surgery

                      $1079.72 Lowest GoodRx priceView Prices
                      Used for:
                      $785.90 Lowest GoodRx priceView Prices

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                      References

                      Best studies we found

                      Alving, J., et al. (2013). Epileptic prodromes: Are they nonconvulsive status epilepticus? Seizure.

                      Billett, H. H. (1990). Chapter 151: Hemoglobin and hematocrit. Clinical Methods: The History, Physical, and Laboratory Examinations, 3rd edition.

                      Mangla, A., et al. (2022). Pure red cell aplasia. StatPearls.

                      View All References (11)

                      MedlinePlus. (2021). Iron tests.

                      MedlinePlus. (2022). Hemoglobin.

                      National Institute of Diabetes and Digestive and Kidney Diseases. (2020). Anemia in chronic kidney disease.

                      National Kidney Foundation. (n.d.). Dialysis.

                      Nguyen, M., et al. (2023). Iron supplementation. StatPearls.

                      Sanchis-Gomar, F., et al. (2013). Erythropoietin receptor (EpoR) agonism is used to treat a wide range of disease. Molecular Medicine.

                      Tenny, S., et al. (2022). Mannitol. StatPearls.

                      U.S. Food and Drug Administration. (2021). Safely using sharps (needles and syringes) at home, at work and on travel.

                      Vifor (International) Inc. (2023). Mircera- methoxy polyethylene glycol-epoetin beta injection, solution [package insert]. DailyMed.

                      Vifor (International) Inc. (2023). Using Mircera® at home: Instructions for subcutaneous injection.

                      You and Your Hormones. (2020). Erythropoietin.

                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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