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Specialty Drug
ALGLUCOSIDASE ALFA is a drug that is used to replace an enzyme that is missing in patients with Pompe disease. It is not a cure. Compare enzyme replacement therapies.
Prescription Settings
1 vial
1 vial

Lumizyme Side Effects

What should I watch for?

Visit your doctor for regular check ups. You may need blood work done while you are taking this medicine. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

You can be a part of a registry for patients with Pompe disease. This registry may ask for information over a long time. Ask your healthcare professional for more information.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Blue lips, fingernails, or skin

body aches or pain

chest discomfort or pain



difficult or labored breathing

difficulty with swallowing


dry, red, hot, or irritated skin

ear congestion

fast, pounding, or irregular heartbeat or pulse

feeling of warmth



hives, itching, or skin rash

increased sweating

irregular, fast, slow, or shallow breathing

lightheadedness, dizziness, or fainting

loss of voice

nasal congestion


pale skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid shallow breathing

redness of the face, neck, arms, and occasionally, upper chest

redness or pain at the catheter site

runny nose

shakiness in the legs, arms, hands, or feet

slow or irregular heartbeat


sore throat

swollen, painful, or tender lymph glands in the neck, armpit, or groin

tightness in the chest

trembling or shaking of the hands or feet

troubled breathing

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

Less common

Blood in the urine


decreased urine

dry mouth

increased thirst

loss of appetite

mood changes

muscle pain or cramps

nausea or vomiting

numbness or tingling in the hands, feet, or lips

pain in the groin or genitals

sharp back pain just below the ribs

Incidence not known

Blue-green to black skin discoloration

blurred vision


dilated neck veins

extreme fatigue

heart stops

inability to speak

no breathing

no pulse or blood pressure

pain, redness, swelling, or sloughing of the skin at the place of injection


severe or sudden headache

severe pain in the chest

slurred speech

sudden and severe weakness in the arm or leg on one side of the body

sudden onset of severe breathing difficulty

swelling of the face, fingers, feet, or lower legs

temporary blindness


weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal or stomach pain

acid or sour stomach


body aches or pain

change in hearing



dryness or soreness of the throat

ear discomfort or pain

ear drainage


feeling of constant movement of self or surroundings

general feeling of discomfort or illness




muscle or bone pain, stiffness, or tightness

muscle twitching

redness of the skin

redness or swelling in the ear

sensation of spinning

sore mouth or tongue

stomach discomfort, upset, or pain

tender, swollen glands in the neck

upper abdominal or stomach pain

voice changes


white patches in the mouth or on the tongue

Less common

Bloody nose

sleepiness or unusual drowsiness

Incidence not known

Burning, dry, or itching eyes

discharge, excessive tearing

muscle spasm

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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