The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Anemia (49%)
- Tiredness (40%)
- Low platelet counts (37%)
- Nausea (35%)
- Trouble breathing (34%)
- Fever (30%)
- Diarrhea (27%)
- Low white blood cell counts (25%)
- Headache (24%)
- Cough (22%)
- Swelling in legs (20%)
Less Common Side Effects
- High blood pressure
- Chills
- Dizziness
- Vomiting
- Lower appetite
- Back pain
- Muscle spasms
- Trouble sleeping
Note: These side effects were reported in people with multiple myeloma taking Kyprolis (carfilzomib) by itself. Side effects might differ for people taking Kyprolis (carfilzomib) along with other anticancer medications.
Kyprolis serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious heart problems: trouble breathing, chest pain, swelling in legs, feeling lightheaded, abnormal heartbeat
- Serious kidney problems: high creatinine levels on blood tests, urinating less often, having less urine, weakness, confusion, nausea
- Tumor lysis syndrome: abnormal heartbeat, muscle cramps, muscle weakness, abnormal electrolyte levels (high potassium, high uric acid, high creatinine, low calcium)
- Serious lung problems: sudden cough, trouble breathing, very quick breathing, clicking or rattling sound when breathing, pain when breathing
- Severely high blood pressure: sudden headache, confusion, chest pain, trouble breathing, blood pressure reading higher than 180/120
- Blood clots: swelling or red and warm skin in one arm or one leg, sudden trouble breathing, sudden chest pain
- Bleeding: nosebleeds, blood in stool or urine, coughing up blood, sudden headache, severe tiredness
- Serious brain and nerve problems: seizures, confusion, vision or speech changes
Source: DailyMed
The following Kyprolis side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Agitation
black, tarry stools
bleeding gums
bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine or stools
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain or tightness
confusion
decreased awareness or responsiveness
decreased urine output
difficult or labored breathing
difficulty with moving
dizziness
drowsiness
fast, slow, or irregular heartbeat
headache
hoarseness
hostility
irritability
loss of consciousness
lower back or side pain
muscle spasms (tetany) or twitching
numbness or tingling in the hands, feet, or lips
painful or difficult urination
pale skin
pinpoint red spots on the skin
pounding in the ears
rapid weight gain
seizures
severe sleepiness
tingling of the hands or feet
trembling
trouble breathing
ulcers, sores, or white spots in the mouth
unsteadiness or awkwardness
unusual bleeding or bruising
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
unusual weight gain or loss
vomiting
Less common
Chills
continuing ringing, buzzing, or other unexplained noise in the ears
hearing loss
muscle pain or cramps
painful blisters on the trunk of the body
weakness in the arms, hands, legs, or feet
Rare
Dark urine
general feeling of discomfort or illness
light-colored stools
stomach pain, continuing
thickening of bronchial secretions
yellow eyes or skin
Incidence not known
Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
blindness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
joint pain, stiffness, or swelling
stomach pain
sweating
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
