The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Diarrhea (up to 52%)
- Nausea (up to 52%)
- Numbness or tingling of the hands or feet (up to 50%)
- Fatigue (up to 41%)
- Nerve pain (up to 34%)
- Constipation (up to 30%)
- Vomiting (up to 29%)
- Lessened or lack of appetite (up to 21%)
- Fever (up to 21%)
*Some side effects listed above might not be from [[EDITOR|DRUG_DISPLAY_NAME]] alone, since some studies included people taking [[EDITOR|DRUG_DISPLAY_NAME]] with other anticancer medications.
**Less nerve problems seen when injected under the skin versus IV.
Less Common Side Effects
- Pain or redness at injection site
- Stomach pain
- Difficulty breathing
- Dizziness
- Weakness
- Headache
- Trouble falling or staying asleep
- Swelling of the legs or feet
- Changes in blood pressure
- Rash
- Shingles infection
- Lung infections
Velcade serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Infections: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
- Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, blood in the urine, throwing up blood, bloody or black and tarry stool
- Extremely low blood pressure: dizziness, lightheadedness, fainting, tiredness, vision changes
- New confusion, seizures, or sudden changes in mood or behavior: severe headaches, visual changes, difficulty staying awake, dizziness, trouble speaking
- Liver damage: dark urine, right-sided stomach pain, yellowing of the eyes or skin, tiredness, loss of appetite, nausea, vomiting
- Heart problems: chest pain, racing heartbeat, shortness of breath that usually worsens with activity or while lying flat, swelling of your legs or feet, sudden weight gain, fatigue, dizziness
Source: DailyMed
The following Velcade side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Black, tarry stools
bleeding gums
blood in the urine or stools
blurred vision
body aches or pain
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chills
confusion
cough producing mucus
decreased urination
difficult or labored breathing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
ear congestion
fainting
headache
increase in heart rate
loss of voice
lower back or side pain
nerve pain
painful blisters on the trunk of the body
painful or difficult urination
pale skin
pinpoint red spots on the skin
rapid breathing
sunken eyes
sweating
swollen glands
thirst
tightness in the chest
troubled breathing with exertion
ulcers, sores, or white spots in the mouth
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
weakness in the arms, hands, legs, or feet
wrinkled skin
Less common
Dilated neck veins
general feeling of discomfort or illness
increased sensitivity to pain
increased sensitivity to touch
irregular breathing
irregular heartbeat
swelling of the face, fingers, feet, or lower legs
thickening of bronchial secretions
tingling in the hands and feet
Incidence not known
Agitation
back pain
blistering, peeling, or loosening of the skin
bruising
change in consciousness
coughing or vomiting blood
dark urine
deafness
deep or fast breathing with dizziness, numbness to feet, hands, and around the mouth
drowsiness
fast heartbeat
general tiredness and weakness
irritability
light-colored stools
loss of consciousness
pain in the stomach, side, or abdomen, possibly radiating to the back
persistent bleeding or oozing from puncture sites, mouth, or nose
pounding, slow heartbeat
rectal bleeding
red skin lesions, often with a purple center
red, irritated eyes
restlessness
seeing, hearing, or feeling things that are not there
seizures
shaking
stiff neck
stomach pain and tenderness
trouble sleeping
upper right stomach pain
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Belching
bone pain
difficulty having a bowel movement
difficulty with moving
feeling unusually cold or shivering
hair loss or thinning of hair
indigestion
joint pain or swelling
loss of appetite
loss of taste
mental depression
muscle cramps
muscle pain or stiffness
pain in the arms or legs
rash
stomach discomfort, upset, or pain
vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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