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Juxtapid Coupon - Juxtapid 10mg capsule

Juxtapid

lomitapide
Used for High Cholesterol
Used for High Cholesterol

Juxtapid (lomitapide) is used to treat a rare, genetic type of high cholesterol, known as homozygous familial hypercholesterolemia (HoFH). It's typically used along with other cholesterol-lowering medications and dietary changes, such as a low-fat diet. Because it has a risk of severe liver damage, only certified healthcare providers can prescribe this medication.

Reviewed by:
reviewer
Shifali Patel, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on January 20, 2022
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsContraindicationsAlternativesLatest newsImagesPricesMedicare
basics-icon

What is Juxtapid (lomitapide)?

What is Juxtapid (lomitapide) used for?

  • Homozygous familial hypercholesterolemia (HoFH, genetic condition that causes high cholesterol)

How Juxtapid (lomitapide) works

Juxtapid (lomitapide) is a microsomal triglyceride transfer protein (MTP) inhibitor. MTP is a protein in your body that helps make cholesterol. Juxtapid (lomitapide) works by blocking MTP, which stops your body from making cholesterol, including low-density lipoprotein cholesterol (LDL-C, a type of "bad cholesterol"). This helps lower the levels of "bad cholesterol" in your blood.

Are you looking for information on gemfibrozil (Lopid) instead?

Drug Facts

Common BrandsJuxtapid
Drug ClassMTP inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Juxtapid (lomitapide)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (79%)
  • Nausea (65%)
  • Indigestion (38%)
  • Vomiting (34%)
  • Stomach pain (34%)
  • Weight loss (24%)
  • Chest pain (24%)
  • Stomach discomfort (21%)
  • Stomach swelling or bloating (21%)
  • Constipation (21%)
  • Gas (21%)
  • Flu (21%)
  • Common cold (17%)
  • Feeling tired (17%)

Other Side Effects

  • Headache
  • Dizziness
  • Back pain
  • Throat pain
  • Acid reflux
  • Urgency to urinate or pass stool
  • Feeling of incomplete passing of stool
  • Fever
  • Stomach flu
  • Stuffy nose
  • Fast heartbeat

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Liver damage: yellowing of the skin or eyes (jaundice), stomach pain or swelling, loss of appetite, dark urine, nausea, vomiting, tiredness, weakness, confusion
  • Allergic reaction: itchy, red rash (hives), shortness of breath, chest tightness, swelling of lips, tongue, face, or eyes

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Arm, back, or jaw pain

chest pain or discomfort

chest tightness or heaviness

dark urine

fast, irregular, pounding, or racing heartbeat or pulse

fever

light-colored stools

loss of appetite

nausea and vomiting

sweating

trouble breathing

unusual tiredness or weakness

upper right abdominal or stomach pain

yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

back pain

belching

chills

constipation

cough

decreased weight

diarrhea

dizziness

excess air or gas in the stomach or intestines

frequent urge to defecate

full or bloated feeling

general feeling of discomfort or illness

headache

heartburn

indigestion

joint pain

muscle aches and pains

passing gas

pressure in the stomach

shivering

sore throat

stomach discomfort, upset, or pain

straining while passing stool

stuffy or runny nose

sweating

swelling of the abdominal or stomach area

trouble sleeping

weakness

Incidence not known

Hair loss or thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Juxtapid (lomitapide)

thumbs-up

Pros

Only need to take once daily

Available in many dosage strengths

Works well as an add-on medication to treat a rare, genetic form of high cholesterol

thumbs-down

Cons

Must remember to take on an empty stomach

Must follow a low-fat diet while taking this medication

Risk of serious liver damage

Only available as a brand medication, so it can be expensive

pharmacist-tips

Pharmacist tips for Juxtapid (lomitapide)

pharmacist

  • Your Juxtapid (lomitapide) dose will be adjusted (up or down) until you and your healthcare provider agree on a dose that works well for you. If you miss a dose, skip the missed dose and wait to take your normal dose at your usual time the next day. If you miss doses for more than 1 week or if you stop taking the medication for more than 1 week, don't restart your medication until discussing it with your provider. The levels in your body might be affected, so your provider might have to make adjustments to your dose.

    • Avoid eating grapefruit or drinking grapefruit juice with Juxtapid (lomitapide). Grapefruit can raise levels of this medication in your body, leading to greater side effects such as stomach pain, bloating, and indigestion.

      • Juxtapid (lomitapide) interacts with many medications. Let your provider and pharmacist know about all the medications you're taking or plan to take, including over-the-counter medications and supplements. They will decide if you need to switch medications or if your dose of Juxtapid (lomitapide) needs to be changed.

        • If you're taking warfarin (Coumadin), a blood thinner, you might need to check your INR (bleeding time) more often. Juxtapid (lomitapide) raises levels of warfarin (Coumadin) in your body, which puts you at higher risk for bleeding.

          • If you're taking cholesterol medications like simvastatin (Zocor) or lovastatin (Mevacor), let your pharmacist or healthcare provider know because you might need a lower dose of Juxtapid (lomitapide). Juxtapid (lomitapide) raises levels of these cholesterol medications in your body, which puts you at greater risk for muscle breakdown and pain.

            • Juxtapid (lomitapide) can cause serious liver damage in some people. If you take other medications that also affect your liver, such as acetaminophen (Tylenol) or methotrexate, let your pharmacist or healthcare provider know. Depending on the medication, you might need to get blood tests done more often to check your liver function.

              • You can only start Juxtapid (lomitapide) if you have a negative pregnancy test. If you're of childbearing age, it's important to use a reliable method of birth control while taking this medication. This is because taking Juxtapid (lomitapide) while pregnant can potentially cause harm to your unborn baby. Juxtapid (lomitapide) can lower how well some birth control pills work, especially if you have diarrhea or vomiting. If this happens, use an alternative form of birth control for 1 week, even if your symptoms go away. If you plan on stopping Juxtapid (lomitapide), remember to continue using birth control for 2 more weeks after your last dose because the medication might still be present in your body for some time. Tell your pharmacist or healthcare provider if you start any new birth control pills while you're taking Juxtapid (lomitapide) because your dose might need to be adjusted.

                faqs

                Frequently asked questions about Juxtapid (lomitapide)

                Why do I need to be on a low-fat diet with Juxtapid (lomitapide)?
                When you're taking Juxtapid (lomitapide), your body doesn't absorb fat as well. Eating foods high in fat can cause unpleasant side effects, such as stomach pain, bloating, nausea, and diarrhea. A low-fat diet helps lower the risk of side effects and stomach problems. If you need help starting or maintaining a low-fat diet, discuss with your healthcare provider or reach out to a Compass Clinical Patient Educator for help.
                Can I drink alcohol with Juxtapid (lomitapide)?
                Juxtapid (lomitapide) has a risk of serious liver damage, and drinking alcohol can raise your chances of having liver problems. If you have a history of liver disease or if you frequently drink alcohol, limit your alcohol intake to one alcoholic drink per day. If you're having trouble limiting your alcohol use, discuss other options with your healthcare provider.
                Why isn't Juxtapid (lomitapide) available at my local pharmacy?
                Juxtapid (lomitapide) needs special monitoring because of its risk of serious liver problems, so it's only available at certified pharmacies. Unlike other medications, the FDA requires this medication to have a Risk Evaluation and Mitigation Strategy (REMS) Program. This program educates you and your healthcare provider about using this medication and makes sure that the medication is safe and appropriate for you. For more questions about the Juxtapid (lomitapide) REMS program, ask your provider, visit the website (link above), or call 1-855-JUXTAPID (1-855-898-2743).
                Can Juxtapid (lomitapide) lower my chances of having a stroke or heart attack?
                There isn't enough data to show if Juxtapid (lomitapide) lowers your chances of developing problems from high cholesterol, such as heart attack, stroke, or death. If you're worried about these conditions, discuss your concerns with your healthcare provider.
                Is it safe to use Juxtapid (lomitapide) during pregnancy?
                No. There aren't any studies looking at the use of Juxtapid (lomitapide) in pregnant people, but based on studies done in pregnant animals, it can cause serious harm to uborn babies. If you plan on becoming pregnant or if you believe you might be pregnant, stop using Juxtapid (lomitapide) and let your healthcare provider know right away. If you become pregnant while taking Juxtapid (lomitapide), call 1-877-902-4099 or visit the website to sign up for the Global Lomitapide Pregnancy Exposure Registry. This registry monitors side effects and outcomes of Juxtapid (lomitapide) in pregnant people and babies.
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                warings-icon

                What are the risks and warnings for Juxtapid (lomitapide)?

                Juxtapid (lomitapide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Serious liver damage

                • Risk factors: History of liver disease | Taking other medications that cause liver damage, such as acetaminophen (Tylenol) | Drinking alcohol

                  There's a risk of serious liver damage and buildup of fat in your liver (hepatic steatosis) while taking Juxtapid (lomitapide). This medication should not be used if you currently have liver disease or damage. If you have a history of liver disease, let your healthcare provider know before you start Juxtapid (lomitapide), since they'll need to check if the medication is safe for you.

                  To make sure your liver is healthy, you'll need to get blood tests done before you start Juxtapid (lomitapide) and routinely while you're taking the medication. Depending on your labs, your provider might adjust your dose. If you have symptoms of liver damage, such as yellowing of your skin or eyes (jaundice), stomach pain or swelling, loss of appetite, dark urine, nausea, vomiting, tiredness, weakness, or confusion, stop taking Juxtapid (lomitapide) and let your provider know right away.

                  Because of this risk of serious liver damage, the FDA has required a Risk Evaluation and Mitigation Strategy (REMS) Program for Juxtapid (lomitapide). Under this program, Juxtapid (lomitapide) is only available at select pharmacies with a prescription from a certified provider. The REMS program educates you and your healthcare provider about this risk and the need for routine liver monitoring to make sure the medication is safe for you. For questions about the Juxtapid (lomitapide) REMS program, visit the website or call 1-855-JUXTAPID (1-855-898-2743).

                  risk-warning

                  Potential harm to your unborn baby

                  • Risk factors: Taking Juxtapid (lomitapide) while pregnant | Breastfeeding

                    Juxtapid (lomitapide) should never be used during pregnancy because of the risk of serious harm to your unborn baby. Studies show serious harm and death to unborn babies in pregnant animals. Because of this risk, you'll need to get a pregnancy test done before starting Juxtapid (lomitapide) to make sure you're not pregnant. Use birth control while taking Juxtapid (lomitapide) and for 2 weeks after your last dose of the medication to avoid becoming pregnant. If you plan on becoming pregnant or you think you might be pregnant, stop using Juxtapid (lomitapide) and call your healthcare provider right away.

                    risk-warning

                    Lower absorption of vitamin E and fatty acids

                    • Risk factors: Taking vitamin E or fatty acids (e.g., omega-3 acids) | History of conditions that affect absorption (e.g., long-term bowel conditions, pancreatic conditions)

                      Juxtapid (lomitapide) can lower the absorption of vitamins that dissolve in fat (fat-soluble vitamins), such as vitamin E. The same is true for dietary supplements containing fatty acids, such as alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). These fatty acids are important for your body's growth and development. Omega-3 fatty acids is a common supplement that contains some of these fatty acids. To prevent these levels from getting too low, your provider will suggest you take daily vitamin E and fatty acid supplements along with Juxtapid (lomitapide). Ask your pharmacist or provider about which supplements and dosages to take.

                      risk-warning

                      Stomach problems

                      • Risk factors: Eating high-fat foods

                        Stomach-related side effects can occur quite commonly while taking Juxtapid (lomitapide), especially if you're eating foods high in fat. It's important to follow a low-fat diet while taking this medication to prevent stomach-related symptoms, such as diarrhea, nausea, vomiting, indigestion, pain, and gas. Some severe cases of diarrhea might require treatment at a hospital. If you have severe diarrhea along with dizziness, lightheadedness, tiredness, or you're urinating less often, stop taking Juxtapid (lomitapide) and let your healthcare provider know right away.

                        risk-warning

                        Interactions with other medications

                        Juxtapid (lomitapide) can interact with many medications. Certain medications can raise Juxtapid (lomitapide) levels in your body and raise your risk of side effects, such as liver damage and stomach symptoms. These medications include verapamil, amlodipine (Norvasc), fluconazole (Diflucan), and fluoxetine (Prozac), among many others. Avoid grapefruit while taking Juxtapid (lomitapide) because this can also raise medication levels in your body and raise the risk of side effects. Let your healthcare provider know about all the medications and supplements you're taking or plan to take so they can make sure Juxtapid (lomitapide) is safe for you to take. You might need to stop or change certain medications, or your provider might lower your Juxtapid (lomitapide) dose.

                        risk-warning

                        Absorption problems

                        • Risk factors: History of genetic conditions that cause absorption problems (e.g., galactose intolerance, glucose-galactose absorption problems, Lapp lactase deficiency

                          Juxtapid (lomitapide) can lead to absorption problems and diarrhea if you have certain rare, genetic health conditions that cause absorption problems. These include galactose intolerance, the Lapp lactase deficiency, and glucose-galactose absorption problems. Avoid using Juxtapid (lomitapide) if you have any of these conditions. Discuss other options with your healthcare provider.

                          dosage

                          Juxtapid (lomitapide) dosage forms

                          Typical dosing for Juxtapid (lomitapide)

                          Your dose will be adjusted based on how well you tolerate the medication and how well it's working to control your cholesterol.

                          The typical starting dose is 5 mg by mouth once daily. The maximum dose is 60 mg by mouth once daily.

                          interactions

                          Interactions between Juxtapid (lomitapide) and other drugs

                          Juxtapid (lomitapide) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Juxtapid (lomitapide). Please note that only the generic name of each medication is listed below.

                          Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                          Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                          contraindications-icon

                          Juxtapid (lomitapide) contraindications

                          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Juxtapid (lomitapide) will not be safe for you to take.
                          alternatives

                          What are alternatives to Juxtapid (lomitapide)?

                          There are a number of medications that your doctor can prescribe in place of Juxtapid (lomitapide). Compare a few possible alternatives below.
                          Juxtapid (lomitapide)
                          Used for:

                          • Homozygous familial hypercholesterolemia (HoFH, genetic condition that causes high cholesterol)

                          View Prices
                          Rosuvastatin (Crestor)
                          Used for:
                          $7.80 Lowest GoodRx priceView Prices
                          Vytorin (ezetimibe / simvastatin)
                          Used for:
                          $44.40 Lowest GoodRx priceView Prices
                          images

                          Juxtapid (lomitapide) images

                          Orange And White A733 10 Mg - Juxtapid 10mg Capsule
                          This medicine is Orange And White Capsule Imprinted With "A733 10 Mg".Orange And White A733 10 Mg - Juxtapid 10mg Capsule
                          Orange And White A733 10 Mg - Juxtapid 10mg Capsule
                          This medicine is Orange And White Capsule Imprinted With "A733 10 Mg".Orange And White A733 10 Mg - Juxtapid 10mg Capsule

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