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Joenja Coupon - Joenja 70mg tablet

Joenja

leniolisib
Used for Immunodeficiency
Used for Immunodeficiency

Joenja (leniolisib) is an oral medication that’s used to treat a rare genetic condition called activated phosphoinositide 3-kinase delta syndrome (APDS), which affects your immune system. It’s for people 12 years of age and older who weigh 99 lbs or more. Joenja (leniolisib) can cause inflammation-related side effects such as sinus pressure and headaches.

Reviewed by:
reviewer
Hannah Elmore, PharmD Candidate
reviewer
Cydnee Ng, PharmD
reviewer
Connie Zheng, PharmD
Last reviewed on July 12, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostImagesReferencesPricesMedicare
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What is Joenja (leniolisib)?

What is Joenja (leniolisib) used for?

  • Activated phosphoinositide 3-kinase delta syndrome (APDS)

How Joenja (leniolisib) works

When you have APDS, there’s a protein in your immune system called phosphoinositide 3-kinase (PI3K) delta that doesn’t function correctly. As a result, your immune system becomes weak. This raises your chances of getting sick and catching infections.

Joenja (leniolisib) is a kinase inhibitor known as PI3K delta inhibitor. It works by blocking the PI3K delta protein’s activity. This helps regulate your immune system and protect your body from infection.

Drug Facts

Common BrandsJoenja
Drug ClassPI3K-delta inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Joenja (leniolisib)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Abnormal number of neutrophils, a type of white blood cell (33%)
  • Headache (24%)
  • Sinus pressure (19%)
  • Drying, itching, or inflammation of the skin (14%)

Other Side Effects

  • Fast heartbeat
  • Diarrhea
  • Fatigue
  • Neck or back pain
  • Hair loss
  • Fever

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Headache
  • Mild skin irritation, redness, or dryness
  • Sinus pain or pressure around the face or forehead
pros-and-cons

Pros and cons of Joenja (leniolisib)

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Pros

First and only medication used to treat APDS

Can be used in children ages 12 years and older who weigh at least 99 lbs

No reports of severe side effects in clinical studies to date

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Cons

Taken twice a day

Can’t take while pregnant or breastfeeding

Shouldn’t be used if you have severe liver problems

pharmacist-tips

Pharmacist tips for Joenja (leniolisib)

pharmacist

  • You can take Joenja (leniolisib) with or without food.

    • If you vomit within one hour of taking Joenja (leniolisib), you’ll need to take another dose of the medication as soon as possible. Lower your chance of nausea and vomiting by taking Joenja (leniolisib) with food.

      • If you’ve forgotten to take Joenja (leniolisib) and it’s been more than six hours from the usual time you take your medication, wait and take your next dose at your usual time. Set an alarm as a reminder to take your medication to help yourself not miss a dose.

        • Store Joenja (leniolisib) at room temperature in its original container. Don’t refrigerate Joenja (leniolisib) because this can damage the medication.

          • Joenja (leniolisib) might interact with certain medications, including St. John's wort and ketoconazole. These medications could change the amount of Joenja (leniolisib) in your body, possibly either making it less likely to work or raising your chances of having side effects. Tell your healthcare provider about all the medications you take, including over-the-counter medications and supplements, before starting Joenja (leniolisib). They can make sure your medications are safe to take together.

            • If you’re able to become pregnant, use birth control while taking Joenja (leniolisib) until one week after your last dose. It’s important to avoid becoming pregnant during treatment because of the medication’s risk of harm to an unborn baby.

              faqs

              Frequently asked questions about Joenja (leniolisib)

              What should I do if I forget to take Joenja (leniolisib) or vomit after taking Joenja (leniolisib)?
              If you miss your Joenja (leniolisib) dose by more than six hours or vomit more than one hour after taking the medication, skip that dose. Then, wait to take your next dose at the regular time you take your medication. But if you vomit within one hour of taking Joenja (leniolisib), you should take another dose as soon as possible. To avoid missing doses, try placing your medication in an area where you’ll see it every day. You can also set a reminder on your phone or use a pill organizer to help you remember to take Joenja (leniolisib).
              What can I do to help with dry, itchy skin that’s caused by Joenja (leniolisib)?
              If your skin gets dry or itchy while you’re taking Joenja (leniolisib), try keeping it moisturized throughout the day. To help add moisture to your skin, you can apply a moisturizing lotion to your skin during the day or try using a humidifier in your home. There are many over-the-counter (OTC) products, like skin moisturizers (Vaseline, Aquaphor) and hydrocortisone, that can help with skin irritation as well. Talk to your pharmacist or healthcare provider about which OTC product might be right for you. They can also recommend other ways to help treat or prevent dry, itchy, or irritated skin.
              How well does Joenja (leniolisib) treat activated phosphoinositide 3-kinase delta syndrome (APDS)?
              So far, one small clinical study showed that people who took Joenja (leniolisib) for 3 months noted improvements in immune-related symptoms of APDS. For example, people who took Joenja (leniolisib) had a larger rise in the amount of certain white blood cells in their body than people who took placebo. Their lymph nodes also shrunk more noticeably than those of people who took placebo. These improvements are important because people with APDS typically have low numbers of white blood cells, which raise their risk of infection. They can also have swollen lymph nodes, which can be a sign of infection. In fact, it’s common for people with APDS to get ear, sinus, upper respiratory tract, and lung infections that won’t go away or come back often. It’s not known whether Joenja (leniolisib) helps with other symptoms of APDS, such as long-term coughing and stomach pain.
              Can I get vaccines while taking Joenja (leniolisib)?
              Maybe. It’s best to get all routine or recommended vaccinations before starting Joenja (leniolisib). And once you start treatment, let your healthcare provider know that you’re taking this medication before getting any vaccines. They can discuss with you whether it’s okay for you to get vaccinated. Some vaccines, such as live vaccines, might not work as well if you get them while you’re taking Joenja (leniolisib). These vaccines include the measles, mumps, and rubella vaccine (MMR) and varicella (chicken pox) vaccine. It’s not known whether other vaccines, such as influenza (flu) and Tdap (tetanus, diphtheria, and pertussis), interact with Joenja (leniolisib).
              Can I take Joenja (leniolisib) if I’m breastfeeding?
              It’s not known whether Joenja (leniolisib) is found in breast milk or what harm it can cause to your infant if you choose to breastfeed during treatment. There’s a possible risk that your infant can experience serious side effects from the medication if the medication does pass into your breast milk. Because of this, you’re recommended to avoid breastfeeding while taking Joenja (leniolisib) until 1 week after your last dose. Talk to your healthcare provider about the risks and benefits if you’re considering breastfeeding while taking Joenja (leniolisib).
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              What are the risks and warnings for Joenja (leniolisib)?

              Joenja (leniolisib) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Harm to unborn baby

              • Risk factors: Pregnant women | Women who can have children

                Based on animal studies, it’s possible that Joenja (leniolisib) can cause harm or birth defects to an unborn baby when taken during pregnancy. While Joenja (leniolisib) hasn’t been studied in human pregnancy, it’s important to be aware of this risk. If you're able to get pregnant, you must take a pregnancy test before starting this medication. Make sure to use birth control while you’re taking Joenja (leniolisib) as well as 1 week after your last dose. Talk to your healthcare provider if you think you might be pregnant or are wanting to become pregnant.

                risk-warning

                Risk from live vaccines

                Talk to your healthcare provider before getting any vaccines while you’re taking Joenja (leniolisib). Your provider can check to see whether the vaccine is safe for you. Certain vaccines might not work as well to protect you from infection if you get them while you’re taking Joenja (leniolisib). These include live vaccines, such as measles, mumps, and rubella (MMR), varicella (chicken pox), yellow fever, and rotavirus vaccines.

                dosage

                Joenja (leniolisib) dosage forms

                Typical dosing for Joenja (leniolisib)

                Joenja (leniolisib) is a tablet that you take by mouth. The typical dose is 70 mg by mouth twice a day (about every 12 hours).

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                How much does Joenja (leniolisib) cost?

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                Joenja (leniolisib) images

                Yellow Oval 70 And Lnb - JOENJA 70mg Tablet
                This medicine is Yellow, Oval Tablet Imprinted With "70" And "Lnb".Yellow Oval 70 And Lnb - JOENJA 70mg Tablet

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                References

                Best studies we found

                Immune Deficiency Foundation. (n.d.). Activated PI3K delta syndrome (APDS).

                Koneti Rao, V., et al. (2023). A randomized, placebo-controlled phase 3 trial of the PI3Kδ inhibitor leniolisib for activated PI3Kδ syndrome. Blood.

                National Organization for Rare Disorders. (2023). Activated phosphoinositide 3-kinase delta syndrome (APDS).

                View All References (2)

                Pharming Healthcare Inc. (2023). Joenja- leniolisib tablet, film coated [package insert]. DailyMed.

                U.S. Food and Drug Administration. (2023). FDA approves first treatment for activated phosphoinositide 3-kinase delta syndrome.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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