Jascayd
Jascayd (nerandomilast) is a prescription medication used to treat a lung condition called idiopathic pulmonary fibrosis (IPF) in adults. It's a PDE4 inhibitor that might help slow the worsening of lung function over time. You take a tablet by mouth twice a day, about 12 hours apart. Common side effects include diarrhea and infections such as COVID-19 and upper respiratory tract infections.
What is Jascayd (nerandomilast)?
What is Jascayd (nerandomilast) used for?
- Idiopathic pulmonary fibrosis (IPF) in adults
How Jascayd (nerandomilast) works
Jascayd (nerandomilast) is a phosphodiesterase 4 (PDE4) inhibitor. It works by blocking a protein called PDE4, which raises the amount of a chemical in your body called cAMP. Higher levels of cAMP can help reduce inflammation and slow the buildup of scar tissue in your lungs.
Drug facts
Side effects of Jascayd (nerandomilast)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Diarrhea (31-42%)
- COVID-19 (13-16%)
- Upper respiratory tract infection (11-13%)
- Depression (11-12%)
- Weight loss (10-11%)
Less Common Side Effects
- Low appetite
- Nausea
- Feeling tired
- Headache
- Vomiting
- Back pain
- Dizziness
The following Jascayd (nerandomilast) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Diarrhea
- Fatigue
- Loss of appetite
- Nausea
- Weight loss
- Worsening mood, feelings of depression
Pros and cons of Jascayd (nerandomilast)
Pros
- Tablet taken by mouth
- Might help slow down lung damage
- Can be taken with other IPF medications
Cons
- Must take twice a day
- Interacts with many common medications
- Commonly causes diarrhea
Pharmacist tips for Jascayd (nerandomilast)
- Take Jascayd (nerandomilast) twice a day, about 12 hours apart, with or without food. Swallow Jascayd (nerandomilast) tablets whole. Don't crush or split them.
- If you're having trouble swallowing Jascayd (nerandomilast), place the tablet in 3 to 4 ounces of room temperature water for 15 to 20 minutes. It won't fully dissolve, but will break into small pieces. Drink the mixture within 2 hours of mixing it, then drink another 3 to 4 ounces of water from the same glass to make sure you get all the medication.
- If you miss a dose of Jascayd (nerandomilast), just skip it and take your next dose at your usual time. Don't double up to make up for a missed dose since this can lead to more side effects.
- Share a list of your medications with your care team so they can check for interactions with Jascayd (nerandomilast).
- Jascayd (nerandomilast) isn't a cure for IPF, but it might help slow down lung damage over time. Tell your prescriber if your breathing or symptoms start to get worse.
- If you're pregnant or planning on becoming pregnant, let your prescriber know since Jascayd (nerandomilast) might raise the risk of a pregnancy loss.
- Store Jascayd (nerandomilast) in its original container to protect the medication from light.
Common questions about Jascayd (nerandomilast)
Yes. Jascayd (nerandomilast) was FDA approved in October 2025.
No, Jascayd (nerandomilast) should be swallowed whole, or you can soak the tablet in water for 15 to 20 minutes if you have trouble swallowing it. Don’t break or crush the tablet since this can change how the medication works.
Weight loss has been reported as a side effect in clinical studies, but it happened most often in people who were also taking Ofev (nintedanib). If you notice weight changes or have concerns about your weight while taking this medication, talk with your prescriber.
In studies, researchers looked at how much air people with IPF could breathe out over time. They found that people taking Jascayd (nerandomilast) were able to breathe out more air after taking a deep breath compared to people taking a placebo. This suggests that Jascayd (nerandomilast) might help slow down the worsening of lung function.
A dose of Jascayd (nerandomilast) can stay in your system for about 3 to 4 days. This is based on the medication's half-life, which is how long it takes for half of the medication to leave your body. Keep in mind, this can vary from person to person.
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Jascayd (nerandomilast) dosage
Typical dosage for Jascayd (nerandomilast)
The typical dose is to take 18 mg by mouth twice a day, about 12 hours apart.
Your dose might differ if you're taking certain medications or if you're having side effects.
What are alternatives to Jascayd (nerandomilast)?
Jascayd (nerandomilast) images
