provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content

Ibuprofen Lysine

Generic Neoprofen
Used for Heart Failure
Used for Heart Failure

Ibuprofen lysine (Neoprofen) is an injectable medication used to treat a heart condition in newborn babies called patent ductus arteriosus (PDA). It's given by a healthcare provider in a hospital setting.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Connie Zheng, PharmD
Last reviewed on May 24, 2022
BasicsFAQsInteractionsPricesMedicare
basics-icon

What is Ibuprofen lysine (Neoprofen)?

What is Ibuprofen lysine (Neoprofen) used for?

  • To close the patent ductus arteriosus (PDA) in babies born too early

How Ibuprofen lysine (Neoprofen) works

Are you looking for information on ibuprofen (Motrin) instead?

Drug Facts

Common BrandsNeoprofen
Drug ClassNSAID
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
faqs

Frequently asked questions about Ibuprofen lysine (Neoprofen)

What is patent ductus arteriosus (PDA)?
Patent ductus arteriosus (PDA) is a condition where a blood vessel near the top of the heart, called the ductus arteriosus, doesn't close normally in babies after they're born. In other words, babies born with PDA have a hole at the top of their heart. This hole causes blood to not flow properly, which can lead to many problems with the heart and lungs. It's most common in premature infants (babies who are born too early).
What is ibuprofen lysine (Neoprofen)?
Ibuprofen lysine (Neoprofen) is a nonsteroidal anti-inflammatory drug (NSAID) that's used to close a PDA in babies who are born early by 2 months or more (32 weeks gestational age or younger). The way it helps to close the blood vessel isn't fully understood, but researchers think it works by blocking chemicals called prostaglandins which normally keep blood vessels open.
How is ibuprofen lysine (Neoprofen) given to my baby?
Ibuprofen lysine (Neoprofen) is infused through the veins (IV). The provider will calculate your baby's dose based on your baby's body weight. Your baby will receive a total of 3 doses of this medication over the course of 2 days. Afterwards, their provider will see how their body responds to this medication.
What if ibuprofen lysine (Neoprofen) doesn't work to treat my child's PDA?
If ibuprofen lysine (Neoprofen) didn't close the blood vessel or if the blood vessel reopens again, your baby's provider might give them a second round of ibuprofen lysine (Neoprofen). Sometimes, their provider might suggest other medication options or surgery.
What are the side effects of ibuprofen lysine (Neoprofen)?
Some common side effects of ibuprofen lysine (Neoprofen) include whole-body inflammation from an infection (sepsis), low red blood cell counts (anemia), bleeding in the brain, breathing problems, stomach problems, lung infection, and kidney damage. Your baby's provider will monitor them for side effects while they're getting treatment with ibuprofen lysine (Neoprofen).
Is there anything I should look out for after my baby gets ibuprofen lysine (Neoprofen)?
During your visits with your baby, look out for signs of skin irritations, bleeds, and any infections during or after ibuprofen lysine (Neoprofen) infusions. Ibuprofen lysine (Neoprofen) can irritate your baby's skin at the location the needle goes into the vein. Your baby's provider will monitor this, but let them know if you notice any redness or swelling in this area. Ibuprofen lysine (Neoprofen) can also affect blood clotting, so keep an eye on your baby for signs of bleeding, including bloody urine or stool. This medication can also mask signs of infection, so watch your baby closely and report any unusual symptoms or behavior to your baby's provider.
GoodRxEducationalIcon

How to save using GoodRx

Compare Prices
1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
Select your free coupon
2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
Show coupon to your pharmacist
3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
Get free couponLearn more
interactions

Interactions between Ibuprofen lysine (Neoprofen) and other drugs

Ibuprofen lysine (Neoprofen) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Ibuprofen lysine (Neoprofen). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Get savings updates for Ibuprofen lysine (Neoprofen)

Receive price alerts, news, and other messages from GoodRx about Ibuprofen lysine (Neoprofen) and other healthcare topics and relevant savings offers.

By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.