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HCG

HCG Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on October 10, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache
  • Irritability
  • Restlessness
  • Depression
  • Fatigue or tiredness
  • Edema (swelling)
  • Early puberty
  • Growth of breasts in males
  • Pain at injection site

Less Common Side Effects

  • Skin redness
  • Itchy skin
  • Rash

HCG serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: trouble breathing, swelling of lips or tongue, rash
  • Ovarian hyperstimulation syndrome (OHSS): severe pelvic or stomach pain and swelling along with nausea, vomiting, sudden weight gain, diarrhea, or trouble breathing
  • Swollen or ruptured ovarian cysts: dull, sharp, or sudden pain, feeling of heaviness or bloating in your lower belly
  • Blood clots: shortness of breath, chest pain, swelling, warmth, or tenderness in the leg or arm, weakness on one side of the body, trouble walking or speaking, vision changes
When do HCG possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Pain at injection site
Risk for serious allergic reaction
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following HCG side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
  • Ovarian hyperstimulation syndrome—stomach or pelvic pain, bloating, nausea, vomiting, diarrhea, weight gain
  • Unexpected hair growth on the face or body, deepening of the voice, acne, mood swings, unexpected breast tissue growth, early onset menstruation, enlarged testicles

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Agitation, feeling irritable or restless
  • Fatigue
  • Headache
  • Pain, redness, or irritation at injection site
  • Swelling of the ankles, hands, or feet
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