The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Lower electrolyte levels (calcium, sodium, magnesium, phosphate) (up to 70%)
- Labs suggesting liver or kidney problems (up to 69%)
- Muscle, bone, or joint pain (up to 42%)
- Constipation (up to 41%)
- High blood pressure (40%)
- Feeling very tired (38%)
- Diarrhea (34%)
Less Common Side Effects
- Swelling
- Cough
- Headache or migraine
- Rash
- Feeling short of breath
- Fever
- Feeling numbness or tingling in the fingers or toes
Please note: Side effect information is from studies of people taking Gavreto (pralsetinib) alone for thyroid cancer.
Gavreto serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Lung inflammation: cough, shortness of breath, fever
- Liver injury: pain in the right side of the stomach, yellowing of the eyes or skin, dark or brown urine
- High blood pressure: headache, dizziness, confusion, chest pain
- Severe bleeding: sudden or painful headache, changes in vision, severe stomach pain, coughing or spitting up blood
- Tumor lysis syndrome: muscle cramps, dark or brown urine, fluttering or pounding heart beat
Source: DailyMed
The following Gavreto side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
- Dry cough, shortness of breath or trouble breathing
- Increase in blood pressure
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Tumor lysis syndrome (TLS)—nausea, vomiting, diarrhea, decrease in the amount of urine, dark urine, unusual weakness or fatigue, confusion, muscle pain or cramps, fast or irregular heartbeat, joint pain
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Bone, joint, or muscle pain
- Constipation
- Diarrhea
- Dry mouth
- Fever
- Swelling of the ankles, hands, or feet
- Unusual weakness or fatigue
Other Gavreto articles
