Furoscix (furosemide) is the first FDA-approved furosemide injection that can be given at home to treat fluid overload in adults with worsening heart failure. It belongs to a class called loop diuretics, which means it works in the kidneys to help remove extra fluid from the body. Furoscix (furosemide) is given under the skin through an Infusor device, which typically takes 5 hours to deliver all of the medication. Common side effects include injection pain, dizziness, and frequent urination.
Treating fluid overload in adults with mild to moderate chronic heart failure
Furoscix (furosemide) is a loop diuretic. It works in the kidneys to get rid of extra water and electrolytes. So Furoscix (furosemide) reduces fluid overload, or swelling in the body, caused by heart failure.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Works well to relieve fluid build up from worsening heart failure
The first FDA-approved furosemide injection that can be given at home
Injection under the skin through an Infusor, instead of infusion through the veins
Limits your movement or bending during the 5-hour infusion
Cellphones, computers, or other wireless devices can affect how the device works if they're placed within a foot of the Infusor
Raises risk of dizziness or falls
Don't give yourself or someone else Furoscix (furosemide) infusion until you understand how to use the medication. Your provider or pharmacist will show you how to do your first injection.
During your 5 hour infusion with Furoscix (furosemide), avoid exercising or bending to prevent the Infusor from falling off. It's also not recommended to travel in a car or plane during the infusion.
Furoscix (furosemide) can get in the way of magnetic resonance imaging (MRI). If you need an MRI, ask with your provider about the safest way to treat your heart failure symptoms on that day.
Furoscix (furosemide) can cause you to sunburn more easily. To lower your risk, make sure to limit or avoid sun exposure during treatment with Furoscix (furosemide). Wear protective clothing when outside, even on overcast days.
Don't use Furoscix (furosemide) during showers, baths, or while swimming since water or any other fluids can damage the Infusor.
Place the Furoscix (furosemide) Infusor can be placed on the belly, on either side of the belly button. If you need another dose, make sure to choose a different area on the other side of the belly button.
Don't inject the medication into skin that's bruised, red, tender, or hard. Don't apply lotions or ointments to the application area since it can cause Furoscix (furosemide) Infusor to not stick as well.
Furoscix (furosemide) isn't meant to be used long-term. As soon as it's safe and practical to do so, your provider will change you back to oral furosemide (Lasix) or another oral water pill.
Throw away your used Furoscix (furosemide) Infusor in a sharps disposal container after each use.
Store Furoscix (furosemide) at room temperature in its original container to protect it from light.
Furoscix (furosemide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Kidney or liver problems | Not drinking enough fluids | Taking higher doses of furosemide | Older adults
Furoscix (furosemide) can cause changes in fluids and electrolytes (e.g., potassium, sodium, calcium, and magnesium). This can cause a buildup of waste products, blood sugar, and dehydration. These effects can sometimes be life-threatening since they can lead to blood clots or worsening kidney or liver problems. Let your provider know if you feel weak, confused, or have dark-colored urine since these might be symptoms of dehydration.
If you are urinating less than usual while taking Furoscix (furosemide), talk with your provider right away. You might need to stop Furoscix (furosemide) to prevent kidney problems.
Risk factors: Bladder problems | Enlarged prostate
Furoscix (furosemide) typically causes you to urinate more, but sometimes the opposite can happen. If you have trouble emptying your bladder, your body might hold on to the extra urine, which can be damaging. Tell your provider if you have trouble urinating or a history of bladder problems. Your provider will likely monitor your blood work carefully to make sure Furoscix (furosemide) is safe for you.
Risk factors: Serious kidney problems | Taking other medications that can cause hearing problems | Taking higher doses of furosemide
There have been reports of hearing problems by people who took furosemide.
These side effects are linked to certain factors such as taking other medications that can cause hearing problems and serious kidney problems. If you experience hearing loss, difficulty hearing, or ringing in the ear while taking Furoscix (furosemide), please talk with your provider right away.
Some medications can interfere with how your body gets rid of Furoscix (furosemide). This can affect the amount of Furoscix (furosemide) in your body, how well it works, and the risk of side effects.
Taking a high dose of methotrexate can raise the amount of Furoscix (furosemide) in your body and put you at higher risk for side effects. On the other hand, taking certain medications like phenytoin (Dilantin) can also affect the amount of Furoscix (furosemide) in your body and might cause the medication to not work as well.
Furoscix (furosemide) also interferes with how your body gets rid of other medications. For example, it shouldn't be taken with lithium because Furoscix (furosemide) causes your body to absorb more of lithium and raise your risk for accidental overdose. Furoscix (furosemide) shouldn’t be taken together with medications that cause hearing problems, such as tobramycin. This is because they can both worsen your hearing.
Let your provider or pharmacist know what other medications you’re taking before and while taking Furoscix (furosemide).
Each device delivers 30 mg under the skin in the first hour, then 12.5 mg under the skin every hour for the next 4 hours. So in total, you'll get 80 mg of furosemide over 5 hours.
People whose kidneys can't produce urine
History of allergy to furosemide or medical tapes
Cirrhosis (liver scarring) or ascites (too much fluid in the stomach)
Treating fluid overload in adults with mild to moderate chronic heart failure
Swelling (edema) due to congestive heart failure, liver problems, or kidney problems
Swelling due to heart failure or kidney disease
Swelling due to liver disease (taken with other medications) - generic Furoscix (furosemide) only
High blood pressure - generic Furoscix (furosemide) only
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scPharmaceuticals. (2022). Application animation.
scPharmaceuticals Inc. (2022). Furoscix- furosemide injection 80 mg/ 10 ml injection [package insert]. DailyMed.
scPharmaceuticals Inc. (2022). scPharmaceuticals announces FDA approval of Furoscix® (furosemide injection), the first and only self-administered, subcutaneous loop diuretic for the at-home treatment of congestion in chronic heart failure. Globe Newswire.
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