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Evenity

Evenity Side Effects

Jenna Clayton, PharmDAllison Gourley, PharmD
Reviewed by Jenna Clayton, PharmD, Allison Gourley, PharmD, Cydnee Ng, PharmD
Last reviewed on August 12, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Joint pain (up to 13%)
  • Headache (up to 7%)

Less Common Side Effects

  • Swelling in the arms or legs
  • Neck pain
  • Having trouble falling or staying asleep
  • Tingling or burning sensation
  • Muscle spasms
  • Weakness
  • Injection site reactions (e.g., pain, redness)

Evenity serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Heart attack: chest pain, pain in the middle or upper back, jaw and throat discomfort, shortness of breath, feeling dizzy
  • Stroke: headache, vision changes, loss of balance, trouble talking, weakness or numbness on only one side of the body, droopy face, trouble breathing, nausea, confusion
  • Fracture in the thigh: dull or aching pain in the thigh, hip, or groin
  • Allergic reaction: hives; rash; swelling of the face, lips, mouth, or tongue; trouble breathing or swallowing
When do Evenity possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Injection site reaction

Source: DailyMed

The following Evenity side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Heart attackpain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • Low calcium level—muscle pain or cramps, confusion, tingling, or numbness in the hands or feet
  • Osteonecrosis of the jaw—pain, swelling, or redness in the mouth, numbness of the jaw, poor healing after dental work, unusual discharge from the mouth, visible bones in the mouth
  • Severe bone, joint, or muscle pain
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Headache
  • Joint pain
  • Muscle spasms
  • Pain, redness, or irritation at injection site
  • Swelling of the ankles, hands, or feet
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