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Topiramate Coupon - Topiramate 120ml of 25mg/ml bottle of oral solution

topiramate solution

Generic Eprontia
Used for Epilepsy, Migraine

Topiramate oral solution (Eprontia) is a type of antiepileptic medication. It can be taken by itself or with other medications to treat certain types of seizures in people 2 years and older. It's also helpful for preventing migraines in people 12 years and older. The oral solution is taken by mouth twice a day. There are many side effects, like tingling of the arms and legs, sleepiness, and weight loss. There are also several medications that it can interact with. Topiramate (Eprontia) is available in both brand-name and generic options.

Reviewed by:
reviewerKristianne Hannemann, PharmD
reviewerCydnee Ng, PharmD
Last reviewed on November 18, 2025
basics-icon

What is Topiramate (Eprontia)?

What is Topiramate (Eprontia) used for?

How Topiramate (Eprontia) works

Topiramate (Eprontia) is an antiepileptic medication. It's not exactly clear how it works. But experts think it blocks certain signals or chemicals in the brain that can make it too active. This might help calm the brain to control seizures and prevent migraines.

When does Topiramate (Eprontia) start working?Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug facts

Common BrandsEprontia
Drug ClassAntiepileptic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
side-effects-icon

Side effects of Topiramate (Eprontia)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Tingling in the arms or legs
  • Sleepiness
  • Dizziness
  • Fatigue
  • Low appetite
  • Weight loss
  • Nervousness
  • Depression
  • Trouble concentrating
  • Trouble remembering things
  • Trouble sleeping
  • Trouble moving or keeping balance
  • Fever
  • Mood changes
  • Change in taste

Less Common Side Effects

  • Nausea
  • Diarrhea
  • Constipation
  • Stomach pain
  • Indigestion
  • Problems with speech
  • Feeling numb
  • Confusion
  • Tremor
  • Bleeds (e.g., nosebleeds, bruising)
  • Upper respiratory tract infection (e.g., runny or stuffy nose, sore throat)

Topiramate (Eprontia) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Vision problems: sudden blurry vision, sudden eye redness, sudden eye pain, other changes in vision
  • Very high body temperature, leading to heat exhaustion or heatstroke: fever, headache, tiredness, dizziness, confusion, nausea, vomiting, muscle cramps, skin that's very warm or hot to the touch
  • Very high acid levels (metabolic acidosis): feeling very tired, breathing very fast, poor appetite, irregular heartbeat
  • Very high ammonia levels: very tired, confused, trouble focusing, vomiting
  • Kidney stone: intense pain in your mid to lower back, side, or lower stomach; dark, cloudy, or bloody urine; feeling the urge to urinate
  • Serious skin reaction: rash, skin pain, blisters, skin peeling, fever, sore throat
  • Serious bleeding: bleeding that's hard to stop, more menstrual bleeding than usual, bloody vomit, blood in the urine or stool, tarry stool
  • Suicidal thoughts or behaviors
When do Topiramate (Eprontia) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Drowsiness
Fatigue
Feeling "pins and needles"
Low appetite
Weight loss
Risk of suicidal thoughts
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Topiramate (Eprontia) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blurred vision

burning, prickling, or tingling sensations

clumsiness or unsteadiness

confusion

continuous, uncontrolled back-and-forth or rolling eye movements

dizziness

double vision

drowsiness

eye redness or pain

generalized slowing of mental and physical activity

increased eye pressure

memory problems

menstrual changes

menstrual pain

nervousness

speech or language problems

trouble in concentrating or paying attention

unusual tiredness or weakness

Less common

Aggression

agitation

chest pain

chills

discouragement

feeling sad or empty

fever

irritability

lack of feeling or emotion

lessening of sensations or perception

loss of appetite

loss of interest or pleasure

red, irritated, or bleeding gums

sore throat

stomach pain

trouble sleeping

weight loss

Rare

Blood in the urine

difficult or painful urination

frequent urination

hearing loss

itching, skin rash

loss of bladder control

lower back or side pain

nosebleeds

pale skin

ringing or buzzing in the ears

swelling

trouble breathing

Incidence not known

Blistering, peeling, or loosening of the skin

bloating

clay-colored stools

constipation

cough

diarrhea

increased rate of breathing

joint or muscle pain

pain or tenderness in the upper stomach

red skin lesions, often with a purple center

sores, ulcers, or white spots in the mouth or on the lips

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Decreased awareness or responsiveness

dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position

severe sleepiness

unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Breast pain in women

tremors

Less common

Back pain

constipation

feeling of warmth

heartburn

increased sweating

leg pain

redness of the face, neck, arms, and occasionally, upper chest

Rare

Decrease in sexual performance or desire

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pros and cons of Topiramate (Eprontia)

Pros

  • Can take by itself or with other medications to control seizures
  • An option for preventing migraines
  • Available as an oral solution, so it's convenient for people who have trouble swallowing pills
  • Approved for both adults and children (age depends on the condition treated)

Cons

pharmacist-tips-icon

Pharmacist tips for Topiramate (Eprontia)

pharmacist
  • Take topiramate (Eprontia) with or without food.
  • Store topiramate (Eprontia) at room temperature. Make sure to throw away the bottle 90 days after you open it, even if there's medication left inside.
  • Use a medication measuring device, like a dosing cup or oral syringe, to measure out your dose of topiramate (Eprontia). Don't use kitchen spoons because they might not be accurate. If you don't have a medication measuring device, ask the pharmacy.
  • If you miss a dose of topiramate (Eprontia), take it as soon as you remember. But if your next dose is in less than 6 hours, skip the missed dose and take your usual dose at the regular time. Don't take two doses at once since that can cause more side effects. Tell your care team if you miss a dose.
  • Topiramate (Eprontia) can make you sleepy, tired, or dizzy. It can also make it hard to concentrate. Don’t drive or do anything that needs your full attention until you know how the medication affects you.
  • It's best not to drink alcohol while taking topiramate (Eprontia). Alcohol can make side effects like drowsiness, dizziness, and tiredness worse. If you have trouble cutting back, ask your care team about finding support or resources.
  • Be sure to stay hydrated while taking topiramate (Eprontia). This helps lower the risk of kidney stones that the medication can cause.
  • Topiramate (Eprontia) can sometimes make you sweat less, which might lead to overheating. When it's hot, try to stay cool and drink plenty of water. Get medical help right away if you have a fever, hot skin, headache, muscle cramps, dizziness, or confusion. These could be signs of heat exhaustion or heatstroke.
  • Topiramate (Eprontia) might raise your risk of bleeding. This can look like more nosebleeds or bruising. But get medical help right away if bleeding won't stop or if you see blood in your urine or stool. This can be signs of serious bleeding.
  • Tell your care team right away if you notice sudden blurry vision, eye pain, or any changes in your vision while taking topiramate (Eprontia). This medication can sometimes cause vision problems that need to be checked out.
  • Talk to your prescriber first before stopping topiramate (Eprontia). Don't stop taking it suddenly because this can raise your risk of seizures. Your prescriber can help you stop safely by slowly lowering your dose.
  • Tell your care team, including your pharmacist, about all the medications you take or plan to take. Topiramate (Eprontia) can interact with many medications. This can include ibuprofen (Advil), blood thinners like warfarin, birth control pills, and valproic acid. These interactions can raise your risk of side effects. Your care team can check for interactions to help keep you safe.
  • Call your prescriber right away if you get pregnant while taking topiramate (Eprontia). This medication can harm your baby. Your prescriber can discuss the risks and benefits of treatment. They can help you find an option that's safer for you and your baby.
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Risks and warnings for Topiramate (Eprontia)

Topiramate (Eprontia) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Vision problems

Some people taking topiramate (Eprontia) have had eye problems. They can be related to nearsightedness and greater pressure in the eye(s). Symptoms can include eye redness, blurry vision, and eye pain. These symptoms usually happen within the first month of treatment, but they can also happen later. Symptoms can come on suddenly.

Tell your care team or eye specialist right away if you notice any changes in your vision while taking topiramate (Eprontia). They can check what's going on because eye problems can become serious if left untreated. If needed, your prescriber can stop the medication to keep your vision from getting worse. To do this safely, they'll help lower your dose slowly over time. Usually, these vision problems will go away after you stop taking the medication.

High body temperature and trouble sweating

  • Risk factor: Children | Hot weather | Taking anticholinergic medications | Taking other medications that make you sweat less

Some people might sweat less while taking topiramate (Eprontia). This can make it harder to control your body temperature. So it can lead to overheating and high body temperature, which is dangerous. The risk might be higher for children. The risk can also be higher if you take other medications that make you sweat less, such as anticholinergic medications.

Pay attention to how much you sweat or how hot you feel while you're exercising or in hot weather. Stay hydrated, use mist fans, and take breaks in the shade on hot days. If you can, try to stay indoors where there's air conditioning when the weather is hot. Call 911 if you or your child has signs of heat stroke or heat exhaustion, like dizziness, hot skin, headache, muscle cramps, or confusion.

Too much acid in the blood (metabolic acidosis)

  • Risk factors: Kidney problems | Severe breathing problems | Diarrhea | Keto diet | Serious seizure condition called status epilepticus

Although rare, topiramate (Eprontia) can raise the acid levels in your blood. This condition is called metabolic acidosis. It can happen at any time during treatment. If left untreated, high acid levels can raise your risk of kidney stones and bone fractures. In children, this condition can lead to poor bone growth.

To monitor this risk, your prescriber will ask you to do a blood test before you start topiramate (Eprontia). You'll also need periodic blood tests during treatment. This helps make sure the acid levels in your blood aren't too high.

Call your care team right away if you have signs of metabolic acidosis while taking topiramate (Eprontia). Signs can include fast breathing, tiredness, loss of appetite, or irregular heartbeat. If your acid levels are too high, your prescriber might lower your dose or stop the medication. If needed, they can give you treatment for metabolic acidosis.

Changes in mood and risk of suicidal thoughts or behavior

  • Risk factors: History of depression | Taking other seizure medications or medications that affect mood

Topiramate (Eprontia) can cause changes in mood. It can also raise the risk of suicidal thoughts or behavior. The risk can appear as early as 1 week after starting the medication.

Make sure your friends and family know to watch for signs of depression or changes in your mood or behavior while you're taking topiramate (Eprontia). This is especially important during the first few months and when your dose goes up. If you start thinking about hurting yourself, call 911 right away.

Problems with memory, speech, or coordination

  • Risk factors: Starting topiramate (Eprontia) at a higher dose | Raising the dose too fast

Topiramate (Eprontia) can make it harder for you to remember things. It can also cause problems with speech and coordination. Tell your care team if you notice you're forgetting things more often, having problems with speech, or having a hard time moving around. They can check what's going on and see how they can help you.

Sleepiness, tiredness, and lower concentration

  • Risk factors: Starting topiramate (Eprontia) at a higher dose | Raising the dose too fast

Topiramate (Eprontia) can make you sleepy or tired. It can also make it harder for you to concentrate. To be safe, don't drive or use machinery until you know how this medication affects you. Also don't drink alcohol with topiramate (Eprontia) because it make these side effects worse.

High ammonia levels in the blood

  • Risk factors: History of metabolic disorders | Taking divalproex (Depakote) or valproic acid | Higher dose of topiramate (Eprontia)

Topiramate (Eprontia) can cause ammonia to build up in your body. The risk is higher if you take it with valproic acid or divalproex (Depakote). Some people might not have symptoms, but others can.

Signs of high ammonia levels include feeling more tired or confused, having trouble concentrating, or vomiting. In serious cases, high ammonia levels can affect the brain. Get medical help right away if you notice any of these symptoms.

Serious skin reactions

Topiramate (Eprontia) has a risk of causing serious skin reactions. This includes Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN). If you have a rash, blisters, skin peeling, other unusual changes in your skin, or high fever, get medical help right away. Your care team will help lower your dose slowly over time to stop the medication. They'll talk to you about safer options to treat your condition.

Kidney stones

  • Risk factors: Men | Keto diet | Taking medications called carbonic anhydrase inhibitors

Topiramate (Eprontia) can raise your risk of kidney stones. The risk might be higher if you follow a ketogenic (keto) diet. You can also be at risk if you take medications called carbonic anhydrase inhibitors, like acetazolamide. Be sure to drink plenty of fluids to help prevent kidney stones.

Risk of seizures if you stop the medication suddenly

Talk to your prescriber before stopping topiramate (Eprontia). Stopping suddenly can raise your risk of seizures. If you take it to control seizures, stopping too quickly can make them come back or happen more often. Your prescriber can help you slowly lower your dose to stop safely.

Bone or growth problems in children

In studies, some children taking topiramate (Eprontia) had signs of having weaker bones. It's unclear if this directly raises the risk of fractures. Get medical help right away if your child breaks a bone while taking this medication. Let their prescriber know afterwards.

Studies also suggest that topiramate (Eprontia) might slow growth in children (in height and weight). The care team will keep track of your child's growth during follow-up visits. Talk to your prescriber if you're worried about your child's growth progress.

Interaction with other medications

Topiramate (Eprontia) can interact with many medications. Some interactions can make medications work less well. Others can put you at risk of side effects. It's important to tell your care team about all the medications you take and plan to take. They can check for interactions and make adjustments to your medications to keep you safe, if needed.

In particular, topiramate (Eprontia) can interact with medications called carbonic anhydrase inhibitors. These include acetazolamide and zonisamide (Zonegran). This can raise the risk of metabolic acidosis and kidney stones.

Another example is taking topiramate (Eprontia) with valproic acid or divalproex (Depakote). This interaction can make your body temperature drop. This can lead to symptoms like shivering, tiredness, trouble moving at your typical speed, confusion, or more seriously, coma. If this happens, get medical help right away.

Harm to an unborn baby

Topiramate (Eprontia) can harm an unborn baby if taken during pregnancy. It's caused birth defects like cleft lip or cleft palate. Some newborns might also be smaller than expected.

Tell your prescriber if you're pregnant or planning to become pregnant. They can explain the risks and benefits of taking topiramate (Eprontia) during pregnancy. If you're not planning a pregnancy, it's recommended that you use birth control while taking this medication to lower your risk.

If you take topiramate (Eprontia) while pregnant, you can join the North American Antiepileptic Drug (NAAED) Pregnancy Registry. This program helps researchers learn more about how safe the medication is for you and your baby.

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Topiramate (Eprontia) dosage

The average cost for 1 bottle of 120ml of 25mg/ml of Topiramate (Eprontia) is $87.22 with a free GoodRx coupon. This is 75.84% off the average retail price of $360.99.
bottle of oral solutionBottle of oral solution
DosageQuantityPrice as low asPrice per unit
473ml of 25mg/ml1 bottle$217.64$217.64
240ml of 25mg/ml1 bottle$169.94$169.94
120ml of 25mg/ml1 bottle$87.22$87.22

Typical dosage for Topiramate (Eprontia)

In general, your prescriber will raise your dose over the first few weeks. The dose depends on why you're taking it and what other medications you take. It also might be lower if you have kidney problems.

  • Seizures (when taken by itself)

    • Adults and children 10 years or older
      • Week 1: The typical dose is 25 mg by mouth in the morning and evening.
      • Week 2: The typical dose is 50 mg by mouth in the morning and evening.
      • Week 3: The typical dose is 75 mg by mouth in the morning and evening.
      • Week 4: The typical dose is 100 mg by mouth in the morning and evening.
      • Week 5: The typical dose is 150 mg by mouth in the morning and evening.
      • Week 6 and beyond: The typical dose is 200 mg by mouth in the morning and evening.
    • Children 2 to 9 years old: The typical starting dose is 25 mg by mouth each night for the first week. The dose is raised each week up to a maintenance dose. Depending on your child's weight, the maintenance dose ranges from 75 mg to 200 mg by mouth twice a day.

  • Seizures (when taken with other anti-seizure medications)

    • Adults 17 years or older: The typical starting dose is 25 mg to 50 mg by mouth once a day. The dose is slowly raised every week up to a maintenance dose. The typical maintenance dose is between 100 mg and 200 mg twice a day.
    • Children 2 to 16 years old: The dose is based on your child's weight. The typical starting dose is 1 mg/kg to 3 mg/kg (up to 25 mg) by mouth each night for the first week. The dose is slowly raised over a few weeks to a maintenance dose. The typical maintenance dose can range from 5 mg/kg to 9 mg/kg daily, split into 2 doses taken throughout the day. The maximum daily dose is 400 mg.

  • Migraine prevention

    • Adults and children 12 years or older
      • Week 1: The typical dose is 25 mg by mouth in the evening.
      • Week 2: The typical dose is 25 mg by mouth in the morning and evening.
      • Week 3: The typical dose is 25 mg by mouth in the morning and 50 mg in the evening.
      • Week 4 and beyond: The typical dose is 50 mg by mouth in the morning and evening.
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Interactions between Topiramate (Eprontia) and other drugs

Topiramate (Eprontia) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Topiramate (Eprontia). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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What are alternatives to Topiramate (Eprontia)?

There are a number of medications that your doctor can prescribe in place of Topiramate (Eprontia). Compare a few possible alternatives below.
Topiramate (Eprontia)
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News about Topiramate (Eprontia)

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Topiramate (Eprontia) images

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This medicine is Yellow Bottle Of Oral Solution.yellow - Topiramate 25mg/mL Oral Solution

References

Best studies we found

Azurity Pharmaceuticals, Inc. (2025). EPRONTIA- topiramate solution [package insert]. DailyMed.

Cheshire, W. P., Jr., et al. (2008). Drug-induced hyperhidrosis and hypohidrosis: Incidence, prevention and management. Drug Safety.

Fariba, K. A., et al. (2024). Topiramate. StatPearls.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.