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Daurismo

Daurismo Side Effects

Allison Baxley, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Allison Baxley, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on October 9, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Higher blood creatinine levels (96%)
  • Changes in electrolyte levels in blood (up to 54%)
  • Anemia (low red blood cell count; 43%)
  • Bleeding (36%)
  • Tiredness (36%)
  • Neutropenic fever (31%)
  • Low platelet count (30%)
  • Swelling (30%)
  • Muscle, joint, or bone pain (30%)
  • Nausea (29%)
  • Higher liver enzyme levels in blood (up to 28%)
  • Trouble breathing (23%)
  • Lower appetite (21%)
  • Taste changes (21%)
  • Mouth sores (21%)
  • Rash (20%)
  • Constipation (20%)

Less Common Side Effects

  • Muscle spasms
  • Diarrhea
  • Vomiting
  • Dizziness
  • Irregular heart beat

Note: Side effects reported by people taking Daurismo (glasdegib) with low-dose cytarabine.

Daurismo serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Changes in heart rhythm: lightheadedness, irregular heartbeat, blurry vision, fainting, loss of consciousness, seizures

Source: DailyMed

The following Daurismo side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Infection—fever, chills, cough, or sore throat
  • Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
  • Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Change in taste
  • Loss of appetite
  • Joint pain
  • Nausea
  • Pain, redness, or swelling with sores inside the mouth or throat
  • Swelling of the ankles, hands, or feet
  • Unusual weakness or fatigue
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