Cycloset, the brand name for bromocriptine, is used along with a nutritious diet and exercise plan to improve blood sugar levels in adults with Type 2 diabetes. But it isn't a first-choice treatment option. Cycloset (bromocriptine) is a type of medication called a dopamine agonist. It comes as tablets that are taken by mouth once per day (within 2 hours of waking up). Side effects include nausea, headache, and sleepiness.
Improving blood sugar levels in adults with Type 2 diabetes, as an add-on to a nutritious diet and exercise routine
Cycloset (bromocriptine) is a type of ergot derivative. It's also known as a dopamine agonist.
The medication works by turning on dopamine receptors in the brain and nervous system. It helps improve your body's response to insulin. This helps lower blood sugar levels after the meals you eat during the day.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Blurred vision
chest pain or discomfort
difficulty in speaking
dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position
double vision
feeling, seeing, or hearing things that are not there
feeling that others are watching you or controlling your behavior
feeling that others can hear your thoughts
headache
inability to move the arms, legs, or facial muscles
inability to speak
nervousness
pain or discomfort in the arms, jaw, back, or neck
pounding in the ears
severe mood or mental changes
slow or fast heartbeat
slow speech
sweating
trouble breathing
unusual behavior
vomiting
Less common—reported more often in patients with Parkinson's disease
Confusion
uncontrolled movements of the body, such as the face, tongue, arms, hands, head, and upper body
Rare—reported more often in patients taking large doses
Increased frequency of urination
loss of appetite, continuing
lower back pain
runny nose, continuing
stomach pain, continuing or severe
weakness
Rare
Black, tarry stools
bloody vomit
fainting
nervousness
seizures
sudden weakness
temporary blindness
unusual headache
vomiting, continuing or severe
Incidence not known
Agitation
blue or pale skin
chest pain, possibly moving to the left arm, neck, or shoulder
chills
difficulty in speaking
double vision
false beliefs that cannot be changed by facts
headache
high fever
high or low blood pressure
inability to move the arms, legs, or facial muscles
inability to speak
increased frequency of urination
loss of bladder control
lower back pain
severe muscle stiffness
trouble breathing
unusual tiredness or weakness
unusually pale skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
drowsiness or tiredness
leg cramps at night
loss of appetite
mental depression
stomach pain
tingling or pain in the fingers and toes when exposed to cold temperatures
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Taken once a day
Helps your body use insulin better
Can take with other diabetes medications
Typically need to take more than 1 tablet for each dose
Not a first-choice treatment for Type 2 diabetes
Risk of unpleasant side effects, like impulsive behavior and hallucinations (seeing things that aren't real)
Take Cycloset (bromocriptine) within 2 hours after you wake up in the morning. Taking the medication at this specific time will help it work as best as it can to control your blood sugar.
If you miss the recommended time to take Cycloset (bromocriptine) or if you forget to take it, skip the missed dose. Then, take your usual dose the next morning at your usual time. Don't double-up on the dose to make up for the missed dose.
Take Cycloset (bromocriptine) with food. Since nausea is a common side effect, food can help lower the risk for stomach-related side effects.
Cycloset (bromocriptine) can make you very sleepy. Don't drive or and do other things that need your concentration if you feel sleepy. Make sure you know how this medication affects you. Let your prescriber know if you already have a problem with staying awake during the day or if you take other medications that make you sleepy.
Be sure to hold onto something stable when you stand up. Cycloset (bromocriptine) can make your blood pressure drop and make you feel dizzy or lose your balance when you get up from a sitting or lying position. Get medical help right away if you fall and hit your head.
Avoid drinking alcohol while you're taking Cycloset (bromocriptine). Alcohol can raise your risk for side effects like low blood pressure, sleepiness, and dizziness. Talk to your prescriber about ways to lessen how much you drink if you need guidance.
Tell your health care team about all the medications that you're taking before and during treatment with Cycloset (bromocriptine). They can review your medication list to make sure your medications are safe to take together.
Ask your prescriber how often you should check your blood sugar levels while you're taking Cycloset (bromocriptine). Keep track of your readings and share them with your care team so they can adjust your dose based on the patterns of your blood sugar levels.
It's possible to have low blood sugar (hypoglycemia) while you're taking Cycloset (bromocriptine). This can especially happen if you're also taking other diabetes medications, such as sulfonylureas like glipizide. Learn to recognize symptoms of hypoglycemia like sweating, shakiness, anxiety, and hunger and know how to treat it.
Work with your care team to come up with a meal plan and exercise routine that works best for you. This will help Cycloset (bromocriptine) work as best as possible for you.
Cycloset (bromocriptine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Low blood pressure | Taking blood pressure medications | Higher Cycloset (bromocriptine) dose
Cycloset (bromocriptine) can cause a drop in blood pressure when you stand from a sitting or lying position. This can lead to dizziness, a loss of balance, fainting, or falls. It can particularly happen when you start this and when your dose gets raised. Your prescriber will check for your risk of this side effect periodically during treatment.
Make sure to get up slowly and hold onto something after you sit or lie down. Contact your prescriber if you faint or have a fall while you're taking Cycloset (bromocriptine). Get checked out right away especially if you fall and hit your head to make sure you're okay.
Risk factors: History of mental health problems (e.g., psychosis)
It isn't recommended for people with severe mental health problems like psychosis to take Cycloset (bromocriptine). Medications like Cycloset (bromocriptine) can worsen symptoms of mental health conditions. They can also make medications used for treating mental health conditions work less well.
Contact your prescriber or psychiatrist right away if you or your loved ones notice that you have any hallucinations or other unusual changes in behavior or thoughts while you're taking Cycloset (bromocriptine).
Some people who take medications like Cycloset (bromocriptine) can have compulsive behavior, more specifically intense urges and behaviors that are hard to control. These behaviors can include an urge to gamble, sexual urges, an urge to shop, or binge eating.
Let your prescriber know if you or your loved ones notice that you have new urges or habits as you take Cycloset (bromocriptine). Your prescriber might need to adjust or stop your medication to help with these urges.
Risk factors: Already feeling sleepy | History of sleep problems | Taking other sedatives or medications that make you sleepy | Drinking alcohol
Cycloset (bromocriptine) can make you sleepy, especially when you first start taking the medication. This sleepiness might go away as you continue treatment. But it can feel more intense if you're also taking other medications that can cause drowsiness, like benzodiazepines, muscle relaxants, and sleep medications.
Don't drive drive a car or do activities that need your full attention until you know how Cycloset (bromocriptine) affects you. Talk to your prescriber if you feel too sleepy or fall asleep without warning after you take Cycloset (bromocriptine).
Risk factors: Heart disease
You can't take Cycloset (bromocriptine) if you've just given birth or if you're breastfeeding. Cycloset (bromocriptine) can stop milk production. It can also raise the risk of serious and life-threatening problems, including high blood pressure, heart attack, seizure, stroke, and psychosis. You're at higher risk if you also have a history of heart problems. Talk with your prescriber for guidance if you're breastfeeding or planning to breastfeed.
Dosage | Quantity | Price as low as | Price per unit |
---|---|---|---|
0.8mg | 60 tablets | $323.05 | $5.38 |
Each tablet contains 0.8 mg of bromocriptine.
The starting dose is 1 tablet by mouth once per day, taken within 2 hours of waking up in the morning. Your prescriber will raise your dose each week by 1 tablet depending on how well Cycloset (bromocriptine) works for you. The recommended dose is 2 to 6 tablets per day.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
History of fainting with a migraine headache
People who have just given birth
People who are breastfeeding
Allergy to ergot-related medications
Improving blood sugar levels in adults with Type 2 diabetes, as an add-on to a nutritious diet and exercise routine
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American Diabetes Association Professional Practice Committee. (2024). 9. Pharmacologic approaches to glycemic treatment: Standards of Care in Diabetes–2025. Diabetes Care.
Defronzo, R. A. (2011). Bromocriptine: A sympatholytic, D2-dopamine agonist for the treatment of type 2 diabetes. Diabetes Care.
Drugs and Lactation Database (LactMed®). (2024). Bromocriptine. National Institute of Child Health and Human Development.
Hamidianjahromi, A., et al. (2022). Impulse control disorders in hyperprolactinemic patients on dopamine agonist therapy. Reviews in Endocrine and Metabolic Disorders.
National Institute of Mental Health. (n.d.). Understanding psychosis.
Packaged by Pharma Packaging Solutions, LLC dba Tjoapack, LLC. (2020). Cycloset- bromocriptine mesylate tablet [package insert]. DailyMed.
Santarus, Inc. (2025). Cycloset- bromocriptine mesylate tablet [package insert]. DailyMed.
You and Your Hormones. (2021). Insulin.
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