Do Sleep Medications like Ambien Increase Your Blood Pressure?

For many of us, getting enough sleep can be a challenge. And trouble sleeping, or insomnia, has been linked to many health issues, including high blood pressure (hypertension).

Many people turn to sleeping pills, either occasionally or regularly, to help them get a good night’s sleep. Common over-the-counter (OTC) options include diphenhydramine (Benadryl, ZzzQuil) and melatonin. Prescription medications, like zolpidem (Ambien), are also available.

Improving your sleep should have a positive impact on your blood pressure. But if sleep aids are part of your regular routine, concerns have emerged that they may be counteracting this potential benefit. And, if you’re combining them with blood pressure medications, interactions are also possible.

Do sleep medications raise your blood pressure?

There’s some research suggesting that taking sleep medications could affect your blood pressure. But overall, the evidence is mixed. And it may depend on which ones you take and how often you take them.

For example, while infrequent, high blood pressure has been reported as a side effect of Ambien. This is also the case with Lunesta (eszopiclone), a similar prescription sleep medication. However, this side effect probably isn’t very likely to happen. And it’s not necessarily being caused by the medications either.

A 2019 study looked at older adults who were taking medications to treat high blood pressure. Researchers found that people who regularly took sleep aids ended up taking more blood pressure medications over time than those who didn’t. It’s possible that regular sleep aid use may have contributed to this difference. But more research is needed to confirm.

Is it safe to take sleeping pills if you have high blood pressure?

Generally, yes, it’s OK to take sleeping pills if you have high blood pressure. But it’s best to check with a healthcare professional first.

Most sleep aids don’t commonly raise your blood pressure as a side effect, especially if you only take them for a short period of time. But it’s a good idea to check with your healthcare team or pharmacist before starting a new medication, including OTC products. That’s because interactions with other medications or health conditions are possible.

If your prescriber says it’s OK to take a sleep medication, it’s usually best to take it for the shortest amount of time possible. Aside from potential blood pressure effects, some of these medications can have their own risks with long-term use, including addiction and dependence.

Can you take a sleep aid with blood pressure medications?

You may be able to take a sleep aid if you’re also taking blood pressure medications. But this can depend on whether the medications will interact.

For example, certain medications used to treat high blood pressure can interact with sleep medications like Ambien. Some examples are diltiazem (Cardizem) and verapamil. They may prevent your liver from breaking down Ambien, which raises the risk of side effects like drowsiness and dizziness. 

Taking Ambien with clonidine can also make you more drowsy. You may also experience side effects if you take a beta blocker, like metoprolol (Lopressor, Toprol XL), with a type of sedating antihistamine called diphenhydramine (Benadryl). Taken together, this can increase the likelihood of metoprolol side effects.

Even melatonin, which most people consider to be a safe sleeping supplement, can interact with a high blood pressure medication called nifedipine (Procardia XL). This interaction won’t make you sleepier. But it may make your blood pressure medication less effective. 

What can you do for better sleep if you have high blood pressure?

Getting a good night’s sleep is an important part of a heart-healthy lifestyle. This usually involves identifying potential contributing factors, improving your sleep hygiene, and, if needed, adding a sleep aid for a short period of time. 

Here are a few tips:

• Review your medication list. As mentioned above, some medications can make it harder to fall or stay asleep. Your prescriber or pharmacist can help identify potential culprits from your medication list.

• Work on your sleep hygiene. Avoid screens (like your phone or TV) at least an hour before bed and limit your caffeine intake to mornings only. Make sure your bedroom is quiet, cool, and dark while you’re trying to sleep. It also helps to establish a consistent bedtime routine that you can follow every night.

• Discuss your sleep aid options. Especially if taken short term, the risk of increased blood pressure from sleep aids appears low. So it’s important to choose one that’s compatible with your age, other health conditions, and current medications. A healthcare professional can suggest options that would be safest for you.

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Written by:

Kristianne Hannemann, PharmD

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

Edited by:

Karla Robinson, MD

Karla Robinson, MD, is a medical editor for GoodRx. She is a licensed, board-certified family physician with almost 20 years of experience in health through varied clinical, administrative, and educational roles.

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