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What Medications Are Used Off Label to Help With Sleep?

These treatments tend to help sleep indirectly, such as by promoting relaxation.

Lauren Smith, MASanjai Sinha, MD
Written by Lauren Smith, MA | Reviewed by Sanjai Sinha, MD
Updated on November 5, 2025
Featuring Stacia Woodcock, PharmDReviewed by Sanjai Sinha, MD | November 5, 2025

Some medications have FDA approval to specifically help with sleep issues. Others may cause drowsiness or relaxation as a side effect, and doctors may prescribe them “off label” for sleep. That means they may help with sleep, even if that’s not what they’re indicated for.

In this video, learn what types of medications may help treat sleep off label, according to Stacia Woodcock, PharmD, Pharmacy Editor at GoodRx Health.

References

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Lauren Smith, MA
Written by:
Lauren Smith, MA
Lauren Smith, MA, has worked in health journalism since 2017. Before joining GoodRx, she was the senior health editor and writer for HealthiNation.
Sanjai Sinha, MD
Reviewed by:
Sanjai Sinha, MD
Sanjai Sinha, MD, is a board-certified physician with over 20 years of experience. He specializes in internal medicine.

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