Key takeaways
Acyclovir (Zovirax) and valacyclovir (Valtrex) are both antiviral medications used to treat infections caused by the herpes simplex virus and varicella-zoster virus, such as cold sores, genital herpes, and shingles. Acyclovir is available in various forms, including oral pills, buccal tablets, topical creams, and ointments, while valacyclovir is only available as an oral tablet. Acyclovir needs to be taken more frequently, up to 5 times a day, whereas valacyclovir is typically taken 2 to 3 times a day, making valacyclovir more convenient. Valacyclovir is converted into acyclovir in your body, so they work similarly. Both medications are prescription-only and do not cure herpes but help manage outbreaks. Common side effects for acyclovir include nausea and skin irritation, while valacyclovir can cause headaches and stomach pain.
