Key takeaways
Acyclovir (Zovirax) and penciclovir (Denavir) are both antiviral medications used to treat herpes virus infections, but they have some key differences. Acyclovir is available in multiple forms, including oral, buccal, and topical, while penciclovir is only available as a topical cream. Acyclovir can treat a variety of herpes infections, such as shingles, chickenpox, and genital herpes, whereas penciclovir is specifically for cold sores. Acyclovir needs to be applied or taken multiple times a day, depending on the form, while Penciclovir must be applied every 2 hours while awake. Both medications are prescription-only and not available over the counter.
