Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Dorzolamide and latanoprost (Xalatan and Xelpros) are both medications used to treat high pressure in the eye caused by conditions like ocular hypertension and open-angle glaucoma. However, they belong to different medication classes. Dorzolamide is a carbonic anhydrase inhibitor, while latanoprost is a prostaglandin. Dorzolamide is typically used as an eye drop three times a day, whereas latanoprost is used once daily in the evening. Dorzolamide is available only as a generic, while latanoprost is available in both brand and generic forms. Common side effects of dorzolamide include burning or stinging in the eye and a bitter taste, while latanoprost can cause changes in eye color and eyelash growth. Dorzolamide can be combined with other medications like brimonidine, whereas latanoprost should not be used more than once daily as it can become less effective. Both medications require careful handling to avoid contamination and potential eye infections.
Dorzolamide
Latanoprost (Xalatan)
Dorzolamide
Latanoprost (Xalatan)
Summary of Trusopt vs. Xalatan
Summary for Carbonic anhydrase inhibitor
Prescription only
Dorzolamide is an eye drop medication used to treat high pressure in the eye in people with glaucoma or ocular hypertension. The dosage is 1 drop applied directly into the affected eye(s) three times per day. It's available as a generic only as the brand-name medication Trusopt has been discontinued. Dorzolamide is a sulfa medication, so it might not be the best choice if you have a serious sulfa allergy. Side effects include burning or stinging in the eye and a bitter taste in the mouth.
Summary for Prostaglandin
Prescription only
Latanoprost (Xalatan) is an eye drop medication. It's used in adults to treat conditions related to high pressure in the eye, such as glaucoma. It works as a prostaglandin to help with high eye pressure. The typical dosage is 1 drop in the affected eye(s) once each night. Side effects include feeling like there's something in the eye, burning, and stinging. Unopened bottles need to be refrigerated. But once opened, you keep the medication at room temperature. Latanoprost (Xalatan) is available as a brand-name and generic medication.
Indications of Trusopt vs. Xalatan
Indications for
Treatment of high pressure in the eye in people with: