Key takeaways
Tramadol (Conzip, Qdolo) and oxycodone (Roxicodone, Oxycontin) are prescription opioids. They’re used to treat pain that isn't relieved by non-opioid pain medications. They work in similar ways to reduce pain, but tramadol also affects other chemicals — including serotonin, which can also contribute to pain relief. Oxycodone and tramadol have similar side effects, such as drowsiness, dizziness, and constipation. But tramadol can also increase your risk of seizures and serotonin syndrome moreso than oxycodone. Additionally, both are controlled substances that can lead to dependence and misuse, as well as overdose. If you or a loved one take tramadol or oxycodone, it’s best to carry naloxone (Narcan) with you at all times. This can rapidly reverse the effects of an overdose, if needed.
