Key takeaways
Pseudoephedrine (Sudafed) and mometasone (Nasonex) are both used to treat nasal and sinus issues, but they work in different ways and are used for different conditions. Pseudoephedrine is a decongestant that you take by mouth to relieve short-term nasal and sinus congestion from allergies or the common cold. It works by narrowing blood vessels in your nose and sinuses. Mometasone, on the other hand, is a corticosteroid nasal spray that reduces inflammation and is used to treat allergy symptoms and nasal polyps. Pseudoephedrine is available over-the-counter but is restricted and must be purchased at the pharmacy counter, while mometasone can be found both over-the-counter and by prescription. Pseudoephedrine can cause side effects like anxiety and difficulty sleeping, whereas mometasone might cause headaches and nosebleeds. Additionally, pseudoephedrine can raise blood pressure, so it’s not recommended for people with heart problems, while mometasone can affect growth in children and may cause vision changes with long-term use.
