Key takeaways
Pseudoephedrine (Sudafed) and Dayquil Cold and Flu (acetaminophen/dextromethorphan/phenylephrine) are both over-the-counter medications used to treat symptoms of the common cold, but they have some key differences. Pseudoephedrine is a decongestant that works by narrowing blood vessels to reduce nasal and sinus congestion. It is available in both immediate-release and extended-release forms, and it can be taken every 4 to 24 hours depending on the formulation. Dayquil Cold and Flu, on the other hand, is a combination medication that includes acetaminophen for pain and fever, dextromethorphan for cough suppression, and phenylephrine for congestion. Since studies show oral phenylephrine is not an effective decongestant, DayQuil Cold and Flu may not be the best choice for relieving congestion. It is typically taken every 4 hours. While pseudoephedrine is restricted and must be purchased at the pharmacy counter, Dayquil Cold and Flu is more readily available on store shelves. Additionally, pseudoephedrine can cause side effects like anxiety and difficulty sleeping, whereas Dayquil Cold and Flu can cause stomach upset and nervousness. Both medications should be used with caution if you have high blood pressure or other medical conditions.
