Key takeaways
Zidovudine (Retrovir) and Combivir (lamivudine/zidovudine) are both medications used to treat HIV. They belong to the same drug class, nucleoside reverse transcriptase inhibitors (NRTIs), which work by stopping the virus from making copies of itself. Zidovudine is also used to prevent mother-to-child HIV transmission, which is not an indication for Combivir. Zidovudine is available as a standalone medication in various forms, including capsules, oral solution, and IV, while Combivir is a combination tablet taken orally. Zidovudine is typically taken multiple times a day, whereas Combivir is taken as one tablet twice daily. Both medications can cause serious blood and muscle problems, but Combivir also includes lamivudine, which can help treat hepatitis B. Zidovudine is available as a generic and is one of the most affordable options, while Combivir is also available as a generic, making it more affordable. Common side effects of zidovudine include headache and nausea, while Combivir can cause headaches, nausea, and fatigue. Both medications require regular blood tests to monitor for side effects and effectiveness.
