Key takeaways
Tacrolimus (Prograf) and sirolimus (Rapamune) are both immunosuppressants used to prevent organ rejection, but they have some key differences. Tacrolimus is a calcineurin inhibitor that used to prvent organ rejection after organ transplant. It lowers the activity of the immune system to prevent it from attacking the new organ and is used for kidney, liver, heart, and lung transplants. Sirolimus also lowers the activity of the immune system, but is only approved to prevent organ rejection after a kidney transplant. It is not recommended for liver and lung transplants due to higher risks of serious complications. Additionally, sirolimus can be used for a condition called lymphangioleiomyomatosis (LAM). Tacrolimus is available in both immediate-release and extended-release forms, while sirolimus comes as tablets or an oral solution. Both medications can cause high blood pressure. Additionally, tacrolimus can also cause side effects like tremors and alter electrolyte levels, whereas sirolimus can lead to high cholesterol levels and slow wound healing. Both medications require regular blood tests to monitor levels, but sirolimus has a long duration in the body, allowing for once-daily dosing.
