Key takeaways
Mucinex D (guaifenesin/pseudoephedrine) and Sudafed (pseudoephedrine) are both over-the-counter medications used to relieve nasal and sinus congestion, often due to allergies or the common cold. They share the active ingredient pseudoephedrine, which is a decongestant. However, Mucinex D also contains guaifenesin, an expectorant that helps loosen mucus in the chest, making it easier to cough out. Mucinex D is available as an extended-release tablet taken every 12 hours, while Sudafed comes in both immediate-release and extended-release forms, with dosing intervals ranging from every 4 to 24 hours. Common side effects of both medications include trouble sleeping and headache. Both medications should not be taken with monoamine oxidase inhibitors (MAOIs) and can raise blood pressure, so it's important to consult with a healthcare professional first if you have heart problems or high blood pressure.
